2.1.1.190: 23S rRNA (uracil1939-C5)-methyltransferase
This is an abbreviated version!
For detailed information about 23S rRNA (uracil1939-C5)-methyltransferase, go to the full flat file.
Reaction
Synonyms
m5U methyltransferase, Mcap0476, RlmCD, RlmD, RlmFO, RNA m5U methyltransferase, RNA uridine methyltransferase A, RumA, SP 1029, SP_1029, YefA, YgcA
ECTree
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Substrates Products
Substrates Products on EC 2.1.1.190 - 23S rRNA (uracil1939-C5)-methyltransferase
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REACTION DIAGRAM
S-adenosyl-L-methionine + uracil1939 in 23S rRNA
S-adenosyl-L-homocysteine + 5-methyluracil1939 in 23S rRNA
S-adenosyl-L-homocysteine + 5-methyluracil1939 in 23S rRNA
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S-adenosyl-L-methionine + uracil1939 in 23S rRNA
S-adenosyl-L-homocysteine + 5-methyluracil1939 in 23S rRNA
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S-adenosyl-L-methionine + uracil1939 in 23S rRNA
S-adenosyl-L-homocysteine + 5-methyluracil1939 in 23S rRNA
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S-adenosyl-L-methionine + uracil1939 in 23S rRNA
S-adenosyl-L-homocysteine + 5-methyluracil1939 in 23S rRNA
a purified recombinant version of YgcA retains its activity and specificity, and methylates U1939 in an RNA transcript in vitro
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S-adenosyl-L-methionine + uracil1939 in 23S rRNA
S-adenosyl-L-homocysteine + 5-methyluracil1939 in 23S rRNA
the enzymatic activity of RumA is measured for a 37-mer 23 RNA segment (19321968) and for a 12-mer 5' segment (19321943) lacking the 3' hairpin
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S-adenosyl-L-methionine + uracil1939 in 23S rRNA
S-adenosyl-L-homocysteine + 5-methyluracil1939 in 23S rRNA
the enzyme specifically methylates uracil1939 at C5 in 23S rRNA. A 40-nucleotide 23 S rRNA fragment (nucleotide 19301969) also serves as an efficient substrate for the enzyme
identification of C5-uracil1939 as reaction product
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S-adenosyl-L-methionine + uracil1939 in 23S rRNA
S-adenosyl-L-homocysteine + 5-methyluracil1939 in 23S rRNA
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rRNA substrate structure, overview
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S-adenosyl-L-methionine + uracil1939 in 23S rRNA
S-adenosyl-L-homocysteine + 5-methyluracil1939 in 23S rRNA
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S-adenosyl-L-methionine + uracil1939 in 23S rRNA
S-adenosyl-L-homocysteine + 5-methyluracil1939 in 23S rRNA
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S-adenosyl-L-methionine + uracil1939 in 23S rRNA
S-adenosyl-L-homocysteine + 5-methyluracil1939 in 23S rRNA
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S-adenosyl-L-methionine + uracil1939 in 23S rRNA
S-adenosyl-L-homocysteine + 5-methyluracil1939 in 23S rRNA
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methylation of U747 and U1939 in Bacillus subtilis rRNA is catalysed by a single enzyme, YefA, MALDI mass spectrometry product identification. YefA is not involved in tRNA methylation, or in 23S rRNA m554 methylation
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additional information
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the enzyme also methylates uracil747 in 23S rRNA
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additional information
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enzyme introduces C5 methylation at both U747 and U1939 of the 23S ribosomal RNA, i. e. catalyzes both the reactions of EC 2.1.1.189 and 2.1.1.190
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additional information
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enzyme introduces C5 methylation at both U747 and U1939 of the 23S ribosomal RNA, i. e. catalyzes both the reactions of EC 2.1.1.189 and 2.1.1.190
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additional information
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the enzyme also methylates uracil747 in 23S rRNA
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