2.1.1.189: 23S rRNA (uracil747-C5)-methyltransferase
This is an abbreviated version!
For detailed information about 23S rRNA (uracil747-C5)-methyltransferase, go to the full flat file.
Word Map on EC 2.1.1.189
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2.1.1.189
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rrnas
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pneumoniae
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archaea
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paralogues
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renamed
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eukaryota
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in-vitro
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s-adenosylmethionine
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thermococcales
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archetypical
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pyrococcus
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methyltransferases
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5-methyl
- 2.1.1.189
- rrnas
- pneumoniae
- archaea
- paralogues
-
renamed
- eukaryota
-
in-vitro
- s-adenosylmethionine
- thermococcales
-
archetypical
-
pyrococcus
- methyltransferases
-
5-methyl
Reaction
Synonyms
m5U methyltransferase, PAB0760, RlmC, RlmCD, RNA uridine methyltransferase B, RumB, SP 1029, SP_1029, YbjF, YefA
ECTree
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General Information
General Information on EC 2.1.1.189 - 23S rRNA (uracil747-C5)-methyltransferase
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evolution
malfunction
metabolism
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PAB0760 originates as RlmD-type m5U methyltransferase and undergoes changes in target specificity after its acquisition by a Thermococcales ancestor from a bacterial source. PAB0760 possesses bacterial RlmC-like activity and specifically methylates the nucleotide equivalent to U747 in Pyrococcus abyssi 23S rRNA, but with a sequence most closely related to the bacterial RlmD, the archetypical enzyme that is specific for m5U1939 in 23S rRNA
evolution
YefA is a COG2265 member. During evolution, COG2265 enzymes have undergone a series of changes in target specificity and YefA is closer to an archetypical m5U methyltransferase. A functional shift has occurred during the evolution of the Bacillus subtilis YefA and YfjO methyltransferases.To reflect its dual specificity, YefA is renamed RlmCD
evolution
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YefA is a COG2265 member. During evolution, COG2265 enzymes have undergone a series of changes in target specificity and YefA is closer to an archetypical m5U methyltransferase. A functional shift has occurred during the evolution of the Bacillus subtilis YefA and YfjO methyltransferases.To reflect its dual specificity, YefA is renamed RlmCD
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comparison of the methylation patterns in 23S rRNAs from YbjF+ and YbjF- strains shows that the latter differs only in the lack of the 5-methyluracil747 modification
malfunction
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enzyme inactivation reduces N1-methylated level of G748 by RlmAII in vivo, leading to telithromycin resistance when the nucleotide A2058, located in domain V of 23S rRNA, is dimethylated by the dimethyltransferase Erm(B)
malfunction
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enzyme inactivation reduces N1-methylated level of G748 by RlmAII in vivo, leading to telithromycin resistance when the nucleotide A2058, located in domain V of 23S rRNA, is dimethylated by the dimethyltransferase Erm(B)
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methylation of uridine747 by the enzyme enhances adjacent guanine748 methylation by RlmAII leading to telithromycin-susceptibility
metabolism
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methylation of uridine747 by the enzyme enhances adjacent guanine748 methylation by RlmAII leading to telithromycin-susceptibility
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