2.1.1.188: 23S rRNA (guanine748-N1)-methyltransferase

This is an abbreviated version!
For detailed information about 23S rRNA (guanine748-N1)-methyltransferase, go to the full flat file.

Reaction

Synonyms

methyltransferase RlmAII, RlmA II, RlmA(II), RlmAII, rRNA large subunit methyltransferase II, TlrB, tylosin resistance methyltransferase RlmA(II), tylosin-resistance methyltransferase RlmA(II)

ECTree

     2 Transferases

         2.1 Transferring one-carbon groups

             2.1.1 Methyltransferases

                2.1.1.188 23S rRNA (guanine748-N1)-methyltransferase

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Results	in table
1	Activating Compound
100	AA Sequence
1	CAS Registry Number
9	Cloned(Commentary)
2	Expression
6	General Information
2	Molecular Weight [Da]
17	Natural Substrates/ Products (Substrates)
22	Organism
11	pH Optimum
14	Protein Variants
11	Purification (Commentary)
1	Reaction
20	Reference
22	Substrates and Products (Substrate)
4	Subunits
37	Synonyms
1	Systematic Name
11	Temperature Optimum [°C]

Natural Substrates Products

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Natural Substrates Products on EC 2.1.1.188 - 23S rRNA (guanine748-N1)-methyltransferase

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NATURAL SUBSTRATE

NATURAL PRODUCT

REACTION DIAGRAM

ORGANISM

UNIPROT

COMMENTARY
(Substrate)

LITERATURE
(Substrate)

COMMENTARY
(Product)

LITERATURE
(Product)

REVERSIBILITY
r=reversible
ir=irreversible
?=not specified

S-adenosyl-L-methionine + guanine748 in 23S rRNA

S-adenosyl-L-homocysteine + N1-methylguanine748 in 23S rRNA

14 entries

S-adenosyl-L-methionine + guanine748 in 23S rRNA

S-adenosyl-L-homocysteine + N1-methyluanine748 in 23S rRNA

Streptomyces fradiae

Q9S1M6

in vivo TlrB modifies nucleotide G748 within helix 35 of 23S rRNA

705762

-

-

?

S-adenosyl-L-methionine + guanine748 in 23S rRNA

S-adenosyl-L-homocysteine + N1-methylguanine748 in 23S rRNA

Bacillus subtilis

-

Gram-positive 23S rRNAs are methylated at G748. 23S rRNA of Gram-negatives is methylated at G745. The position of an RNA methylation defines a sharp division between the Gram-negative and Gram-positive bacteria. Specificity of methylation is determined solely by the methyltransferase enzyme and is independent of the origin of the rRNA substrate

441501

-

-

?

S-adenosyl-L-methionine + guanine748 in 23S rRNA

S-adenosyl-L-homocysteine + N1-methylguanine748 in 23S rRNA

Corynebacterium glutamicum

-

Gram-positive 23S rRNAs are methylated at G748. 23S rRNA of Gram-negatives is methylated at G745. The position of an RNA methylation defines a sharp division between the Gram-negative and Gram-positive bacteria. Specificity of methylation is determined solely by the methyltransferase enzyme and is independent of the origin of the rRNA substrate

441501

-

-

?

S-adenosyl-L-methionine + guanine748 in 23S rRNA

S-adenosyl-L-homocysteine + N1-methylguanine748 in 23S rRNA

Enterococcus faecalis

-

Gram-negative 23 S rRNAs are methylated at G745. 23S rRNA of Gram-positives is methylated at G748. The position of an RNA methylation defines a sharp division between the Gram-negative and Gram-positive bacteria. Specificity of methylation is determined solely by the methyltransferase enzyme and is independent of the origin of the rRNA substrate. Enterococcus faecalis shows intrinsic 23S rRNA methylation at G748. No methylation is determined with the recombinant protein in vivo or in vitro

441501

-

-

?

S-adenosyl-L-methionine + guanine748 in 23S rRNA

S-adenosyl-L-homocysteine + N1-methylguanine748 in 23S rRNA

Lactiplantibacillus plantarum

-

Gram-negative 23 S rRNAs are methylated at G745. 23S rRNA of Gram-positives is methylated at G748. The position of an RNA methylation defines a sharp division between the Gram-negative and Gram-positive bacteria. Specificity of methylation is determined solely by the methyltransferase enzyme and is independent of the origin of the rRNA substrate. Lactobacillus plantarum shows intrinsic 23S rRNA methylation at G748. No methylation is determined with the recombinant protein in vivo or in vitro

441501

-

-

?

S-adenosyl-L-methionine + guanine748 in 23S rRNA

S-adenosyl-L-homocysteine + N1-methylguanine748 in 23S rRNA

Lactococcus lactis

-

Gram-negative 23 S rRNAs are methylated at G745. 23S rRNA of Gram-positives is methylated at G748. The position of an RNA methylation defines a sharp division between the Gram-negative and Gram-positive bacteria. Specificity of methylation is determined solely by the methyltransferase enzyme and is independent of the origin of the rRNA substrate. Lactococcus lactis shows intrinsic 23S rRNA methylation at G748. No methylation is determined with the recombinant protein in vivo or in vitro

441501

-

-

?

S-adenosyl-L-methionine + guanine748 in 23S rRNA

S-adenosyl-L-homocysteine + N1-methylguanine748 in 23S rRNA

Micromonospora griseorubida

-

Gram-positive 23S rRNAs are methylated at G748. 23S rRNA of Gram-negatives is methylated at G745. The position of an RNA methylation defines a sharp division between the Gram-negative and Gram-positive bacteria. Specificity of methylation is determined solely by the methyltransferase enzyme and is independent of the origin of the rRNA substrate

441501

-

-

?

S-adenosyl-L-methionine + guanine748 in 23S rRNA

S-adenosyl-L-homocysteine + N1-methylguanine748 in 23S rRNA

Priestia megaterium

-

Gram-negative 23 S rRNAs are methylated at G745. 23S rRNA of Gram-positives is methylated at G748. The position of an RNA methylation defines a sharp division between the Gram-negative and Gram-positive bacteria. Specificity of methylation is determined solely by the methyltransferase enzyme and is independent of the origin of the rRNA substrate. Bacillus megaterium shows intrinsic 23S rRNA methylation at G748. No methylation is determined with the recombinant protein in vivo or in vitro

441501

-

-

?

S-adenosyl-L-methionine + guanine748 in 23S rRNA

S-adenosyl-L-homocysteine + N1-methylguanine748 in 23S rRNA

Rhodococcus corynebacterioides

-

Gram-negative 23 S rRNAs are methylated at G745. 23S rRNA of Gram-positives is methylated at G748. The position of an RNA methylation defines a sharp division between the Gram-negative and Gram-positive bacteria. Specificity of methylation is determined solely by the methyltransferase enzyme and is independent of the origin of the rRNA substrate. Nocardia corynebacteroides shows intrinsic 23S rRNA methylation at G748. No methylation is determined with the recombinant protein in vivo or in vitro

441501

-

-

?

S-adenosyl-L-methionine + guanine748 in 23S rRNA

S-adenosyl-L-homocysteine + N1-methylguanine748 in 23S rRNA

Streptococcus pneumoniae

-

-

733110, 734806

-

-

?

S-adenosyl-L-methionine + guanine748 in 23S rRNA

S-adenosyl-L-homocysteine + N1-methylguanine748 in 23S rRNA

Streptococcus pneumoniae

-

Gram-positive 23S rRNAs are methylated at G748. 23S rRNA of Gram-negatives is methylated at G745. The position of an RNA methylation defines a sharp division between the Gram-negative and Gram-positive bacteria. Specificity of methylation is determined solely by the methyltransferase enzyme and is independent of the origin of the rRNA substrate

441501

-

-

?

S-adenosyl-L-methionine + guanine748 in 23S rRNA

S-adenosyl-L-homocysteine + N1-methylguanine748 in 23S rRNA

Streptococcus pneumoniae S1

-

-

733110, 734806

-

-

?

S-adenosyl-L-methionine + guanine748 in 23S rRNA

S-adenosyl-L-homocysteine + N1-methylguanine748 in 23S rRNA

Streptococcus thermophilus

-

Gram-negative 23 S rRNAs are methylated at G745. 23S rRNA of Gram-positives is methylated at G748. The position of an RNA methylation defines a sharp division between the Gram-negative and Gram-positive bacteria. Specificity of methylation is determined solely by the methyltransferase enzyme and is independent of the origin of the rRNA substrate. Streptococcus thermophilus shows intrinsic 23S rRNA methylation at G748. No methylation is determined with the recombinant protein in vivo or in vitro

441501

-

-

?

S-adenosyl-L-methionine + guanine748 in 23S rRNA

S-adenosyl-L-homocysteine + N1-methylguanine748 in 23S rRNA

Streptomyces fradiae

Q9S1M6

Gram-positive 23S rRNAs are methylated at G748. 23S rRNA of Gram-negatives is methylated at G745. The position of an RNA methylation defines a sharp division between the Gram-negative and Gram-positive bacteria. Specificity of methylation is determined solely by the methyltransferase enzyme and is independent of the origin of the rRNA substrate

441501

-

-

?

S-adenosyl-L-methionine + guanine748 in 23S rRNA

S-adenosyl-L-homocysteine + N1-methylguanine748 in 23S rRNA

Streptomyces fradiae

Q9S1M6

the methyltransferase RlmAII (TlrB) confers resistance to the macrolide antibiotic tylosin in the drug-producing strain Streptomyces fradiae. The resistance conferred by RlmAII is highly specific for tylosin, and no resistance is conferred to other macrolide drugs, or to lincosamide and streptogramin B drugs that bind to the same region on the bacterial ribosome

659709

-

-

?