2.1.1.186: 23S rRNA (cytidine2498-2'-O)-methyltransferase
This is an abbreviated version!
For detailed information about 23S rRNA (cytidine2498-2'-O)-methyltransferase, go to the full flat file.
Reaction
Synonyms
2O-ribose methyltransferase, Cm2498, RlmM, rRNA large subunit methyltransferase M, ygdE
ECTree
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Substrates Products
Substrates Products on EC 2.1.1.186 - 23S rRNA (cytidine2498-2'-O)-methyltransferase
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REACTION DIAGRAM
S-adenosyl-L-methionine + cytidine2498 in 23S rRNA
S-adenosyl-L-homocysteine + 2'-O-methylcytidine2498 in 23S rRNA
S-adenosyl-L-homocysteine + 2'-O-methylcytidine2498 in 23S rRNA
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S-adenosyl-L-methionine + cytidine2498 in 23S rRNA
S-adenosyl-L-homocysteine + 2'-O-methylcytidine2498 in 23S rRNA
YgdE is the 2'-O-methyltransferase responsible for modifying 23S rRNA nucleotide C2498. Modification occurs before assembly of the 50S ribosomal subunit
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S-adenosyl-L-methionine + cytidine2498 in 23S rRNA
S-adenosyl-L-homocysteine + 2'-O-methylcytidine2498 in 23S rRNA
the recombinant YgdE methyltransferase modifies C2498 in naked 23S rRNA, but not in assembled 50S subunits or ribosomes. Nucleotide C2498 is situated within a highly conserved and heavily modified rRNA sequence, and the activity of YgdE is influenced by other modification enzymes that target this region
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S-adenosyl-L-methionine + cytidine2498 in 23S rRNA
S-adenosyl-L-homocysteine + 2'-O-methylcytidine2498 in 23S rRNA
RlmM is active on 23S rRNA from an RlmM knockout strain but not on mature 50S subunits from the same strain
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S-adenosyl-L-methionine + cytidine2498 in 23S rRNA
S-adenosyl-L-homocysteine + 2'-O-methylcytidine2498 in 23S rRNA
23S rRNA substrate structure, overview. The S-adenosyl-L-methionine-binding site is open and shallow, suggesting that RNA substrate binding may be required to form a conformation needed for catalysis. RlmM uses one side of the two domains and the inter-domain linker to recognize its RNA substrate
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S-adenosyl-L-methionine + cytidine2498 in 23S rRNA
S-adenosyl-L-homocysteine + 2'-O-methylcytidine2498 in 23S rRNA
RlmM is active on 23S rRNA from an RlmM knockout strain but not on mature 50S subunits from the same strain
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-
?
S-adenosyl-L-methionine + cytidine2498 in 23S rRNA
S-adenosyl-L-homocysteine + 2'-O-methylcytidine2498 in 23S rRNA
23S rRNA substrate structure, overview. The S-adenosyl-L-methionine-binding site is open and shallow, suggesting that RNA substrate binding may be required to form a conformation needed for catalysis. RlmM uses one side of the two domains and the inter-domain linker to recognize its RNA substrate
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-
?