2.1.1.184: 23S rRNA (adenine2085-N6)-dimethyltransferase

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For detailed information about 23S rRNA (adenine2085-N6)-dimethyltransferase, go to the full flat file.

Reaction

2 S-adenosyl-L-methionine +

Synonyms

23S ribosomal RNA adenine N-6 methyltransferase, EC 2.1.1.48, ErmC, ermC 23 S rRNA methyltransferase, ErmC 23S rRNA methyltransferase, ermC methylase, ErmC methyltransferase, ErmC', ErmC' methyltransferase, ErmC' MTase, erythromycin resistance protein, rRNA methyltransferase ErmC', rRNA:m6A methyltransferase ErmC'

ECTree

     2 Transferases

         2.1 Transferring one-carbon groups

             2.1.1 Methyltransferases

                2.1.1.184 23S rRNA (adenine2085-N6)-dimethyltransferase

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Results	in table
322	AA Sequence
3	Application
5	Cloned(Commentary)
3	Crystallization (Commentary)
2	Expression
3	General Information
3	IC50 Value
8	Inhibitors
48	kcat/KM [mM/s]
6	Ki Value [mM]
58	KM Value [mM]
1	Localization
6	Natural Substrates/ Products (Substrates)
17	Organism
1	PDB ID
6	pH Optimum
1	pH Range
35	Protein Variants
4	Purification (Commentary)
5	Reaction
15	Reference
24	Substrates and Products (Substrate)
20	Synonyms
1	Systematic Name
6	Temperature Optimum [°C]
49	Turnover Number [1/s]

IC50 Value

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IC50 Value on EC 2.1.1.184 - 23S rRNA (adenine2085-N6)-dimethyltransferase

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IC50 VALUE [mM]

INHIBITOR

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

IMAGE

0.3

2-([[(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)methyl][3-(1H-imidazol-1-yl)propyl]amino]methyl)-1H-isoindole-1,3(2H)-dione

Bacillus subtilis

P13956

pH 7.5, 25°C

703219

0.18

4-methyl-2,6-di[(4-methylphenyl)thio]nicotinonitrile

Bacillus subtilis

P13956

pH 7.5, 25°C

703219

0.25

nicotinaldehyde-N-[3-(2-chlorobenzyl)-3H-[1,2,3]triazolo[4,5-d]pyrimidin-7-yl]hydrazone

Bacillus subtilis

P13956

pH 7.5, 25°C

703219