2.1.1.184: 23S rRNA (adenine2085-N6)-dimethyltransferase
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For detailed information about 23S rRNA (adenine2085-N6)-dimethyltransferase, go to the full flat file.
Word Map on EC 2.1.1.184
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2.1.1.184
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macrolide
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macrolide-lincosamide-streptogramin
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methyltransferases
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lincosamide
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unmethylated
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mtases
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streptogramine
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medicine
- 2.1.1.184
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macrolide
-
macrolide-lincosamide-streptogramin
- methyltransferases
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lincosamide
-
unmethylated
- mtases
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streptogramine
- medicine
Reaction
2 S-adenosyl-L-methionine + = 2 S-adenosyl-L-homocysteine +
Synonyms
23S ribosomal RNA adenine N-6 methyltransferase, EC 2.1.1.48, ErmC, ermC 23 S rRNA methyltransferase, ErmC 23S rRNA methyltransferase, ermC methylase, ErmC methyltransferase, ErmC', ErmC' methyltransferase, ErmC' MTase, erythromycin resistance protein, rRNA methyltransferase ErmC', rRNA:m6A methyltransferase ErmC'
ECTree
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Expression
Expression on EC 2.1.1.184 - 23S rRNA (adenine2085-N6)-dimethyltransferase
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direct autoregulatory mechanism operating at the posttranscriptional level and independently of the ermC methylase-mediated methylation of ribosomes. A translational repression model is suggested in which the ermC methyltransferase binds to its own mRNA, at a region that resembles the methylation target site on 23S rRNA
induction is due to a posttranscriptional mechanism in which the inducer activates translation of methylase mRNA by binding to unmethylated (erythromycin-sensitive) ribosomes and stalling them in the leader region. Pseudomonic acid A can also induce methylase synthesis. Isoleucine starvation has a similar effect on ribosomes translating the ermC leader region to cause induction of methylase synthesis. Requirement for ribosome stalling and destabilization of a stem-loop structure and demonstration that stalling can occur without macrolide-bound ribosomes