2.1.1.183: 18S rRNA (adenine1779-N6/adenine1780-N6)-dimethyltransferase
This is an abbreviated version!
For detailed information about 18S rRNA (adenine1779-N6/adenine1780-N6)-dimethyltransferase, go to the full flat file.
Word Map on EC 2.1.1.183
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2.1.1.183
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pombe
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schizosaccharomyces
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tri-snrnps
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mitosis
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pre-rrnas
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nucleolar
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fission
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collagen
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ribonucleoprotein
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oncogene
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spindle
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thioredoxin-like
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pre-ribosomal
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anaphase-promoting
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metastasis-associated
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salivary
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pirin
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spliceosomal
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transketolase
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v-ha-ras
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adenoid
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cyclosome
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snrnp
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cystic
- 2.1.1.183
- pombe
-
schizosaccharomyces
-
tri-snrnps
-
mitosis
- pre-rrnas
-
nucleolar
-
fission
- collagen
- ribonucleoprotein
- oncogene
-
spindle
-
thioredoxin-like
-
pre-ribosomal
-
anaphase-promoting
-
metastasis-associated
-
salivary
- pirin
-
spliceosomal
- transketolase
-
v-ha-ras
-
adenoid
-
cyclosome
-
snrnp
-
cystic
Reaction
4 S-adenosyl-L-methionine + = 4 S-adenosyl-L-homocysteine +
Synonyms
18S rRNA dimethylase Dim1p, DIM1, Dim1p, EC 2.1.1.48, KIDIM1, m2(6)A dimethylase, ScDim1
ECTree
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General Information
General Information on EC 2.1.1.183 - 18S rRNA (adenine1779-N6/adenine1780-N6)-dimethyltransferase
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malfunction
physiological function
DIM1 is involved in pre-rRNA processing
a conditional GAL1O::diml strain is constructed to allow the depletion of Dimlp from the cell. During depletion, dimethylation of the pre-rRNA is progressively inhibited and pre-rRNA processing at cleavage sites A1 and A2 is concomitantly lost. In consequence, the mature 18s rRNA and its 20s precursor drastically underaccumulate. This has the effect of preventing the synthesis of nonmethylated rRNA
malfunction
isolation of mutations that uncouple the enzymatic function of Dim1p in methylation from its involvement in prerRNA processing
malfunction
neither the bacterial nor the archaeal ortholog could complement for the eukaryotic Dim1. This might be related to the secondary, non-methyltransferase function that Dim1 is known to play in eukaryotic ribosomal maturation