2.1.1.182: 16S rRNA (adenine1518-N6/adenine1519-N6)-dimethyltransferase

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For detailed information about 16S rRNA (adenine1518-N6/adenine1519-N6)-dimethyltransferase, go to the full flat file.

Reaction

4 S-adenosyl-L-methionine +

Synonyms

16S rRNA adenine dimethyltransferase, EC 2.1.1.48, KsgA, ksgA methyltransferase, RsmA, S-adenosylmethionine-6-N',N'-adenosyl (rRNA) dimethyltransferase

ECTree

     2 Transferases

         2.1 Transferring one-carbon groups

             2.1.1 Methyltransferases

                2.1.1.182 16S rRNA (adenine1518-N6/adenine1519-N6)-dimethyltransferase

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Results	in table
38645	AA Sequence
3	Application
11	Cloned(Commentary)
1	Cofactor
3	Crystallization (Commentary)
25	General Information
1	IC50 Value
2	Inhibitors
1	KM Value [mM]
6	Metals/Ions
4	Molecular Weight [Da]
7	Natural Substrates/ Products (Substrates)
264	Organism
29	PDB ID
3	pH Optimum
1	pH Range
8	Protein Variants
8	Purification (Commentary)
2	Reaction
30	Reference
19	Substrates and Products (Substrate)
4	Subunits
26	Synonyms
1	Systematic Name
2	Temperature Optimum [°C]

Inhibitors

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Inhibitors on EC 2.1.1.182 - 16S rRNA (adenine1518-N6/adenine1519-N6)-dimethyltransferase

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INHIBITOR

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

IMAGE

protein S21

Escherichia coli

-

S21 probably inhibits KsgA activity in an indirect way, presumably by stabilizing 30S in a conformation that for whatever reason cannot be methylated by KsgA

701901

-

additional information

Escherichia coli

-

a mixture of 30 S ribosomal proteins inhibits methylation of mutant 30 S ribosomes. This inhibition can be ascribed to ribosomal protein S21. Initiation factor 3 partially inhibits methylation of mutant 30 S ribosomes

704371

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