2.1.1.180: 16S rRNA (adenine1408-N1)-methyltransferase
This is an abbreviated version!
For detailed information about 16S rRNA (adenine1408-N1)-methyltransferase, go to the full flat file.
Word Map on EC 2.1.1.180
Reaction
Synonyms
16S rRNA (m1A1408) methyltransferase, 16S rRNA m1A1408 methyltransferase, 16S rRNA:m(1)A1408 methyltransferase, A1408 16S rRNA methyltransferase, KAM, KamB, kanamycin-apramycin resistance methylase, Kmr, m1A1408, Npm, NpmA, plasmid-mediated 16S rRNA methyltransferase A, ShKam
ECTree
2.1.1.180 16S rRNA (adenine1408-N1)-methyltransferaseAdvanced search results
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results (Substrates Products
Substrates Products on EC 2.1.1.180 - 16S rRNA (adenine1408-N1)-methyltransferase
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SUBSTRATE 
PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
S-adenosyl-L-methionine + adenine1408 in 16S rRNA
S-adenosyl-L-homocysteine + N1-methyladenine1408 in 16S rRNA
S-adenosyl-L-methionine + adenosine1408 in 16S rRNA
S-adenosyl-L-homocysteine + N1-methyladenosine1408 in 16S rRNA
the enzyme provides a panaminoglycoside-resistant nature through interference with the binding of aminoglycosides toward the A site of 16S rRNA through N-1 methylation at position A1408
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S-adenosyl-L-methionine + adenine1408 in 16S rRNA
S-adenosyl-L-homocysteine + N1-methyladenine1408 in 16S rRNA
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?
S-adenosyl-L-methionine + adenine1408 in 16S rRNA
S-adenosyl-L-homocysteine + N1-methyladenine1408 in 16S rRNA
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?
S-adenosyl-L-methionine + adenine1408 in 16S rRNA
S-adenosyl-L-homocysteine + N1-methyladenine1408 in 16S rRNA
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?
S-adenosyl-L-methionine + adenine1408 in 16S rRNA
S-adenosyl-L-homocysteine + N1-methyladenine1408 in 16S rRNA
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?
S-adenosyl-L-methionine + adenine1408 in 16S rRNA
S-adenosyl-L-homocysteine + N1-methyladenine1408 in 16S rRNA
NpmA is an adenine N-1 methyltransferase specific for the A1408 position at the A site of 16S rRNA
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S-adenosyl-L-methionine + adenine1408 in 16S rRNA
S-adenosyl-L-homocysteine + N1-methyladenine1408 in 16S rRNA
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?
S-adenosyl-L-methionine + adenine1408 in 16S rRNA
S-adenosyl-L-homocysteine + N1-methyladenine1408 in 16S rRNA
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?
S-adenosyl-L-methionine + adenine1408 in 16S rRNA
S-adenosyl-L-homocysteine + N1-methyladenine1408 in 16S rRNA
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resistance to kanamycin plus apramycin results from conversion of residue adenine1408 to 1-methyladenine
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?
S-adenosyl-L-methionine + adenine1408 in 16S rRNA
S-adenosyl-L-homocysteine + N1-methyladenine1408 in 16S rRNA
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precise location of methylation site
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S-adenosyl-L-methionine + adenine1408 in 16S rRNA
S-adenosyl-L-homocysteine + N1-methyladenine1408 in 16S rRNA
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?
S-adenosyl-L-methionine + adenine1408 in 16S rRNA
S-adenosyl-L-homocysteine + N1-methyladenine1408 in 16S rRNA
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?
S-adenosyl-L-methionine + adenine1408 in 16S rRNA
S-adenosyl-L-homocysteine + N1-methyladenine1408 in 16S rRNA
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?
additional information
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the enzyme possesses also methylates 30S subunits with guanine1408
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additional information
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enzyme has low affinity for cosubstrate S-adenosylmethionine
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