2.1.1.179: 16S rRNA (guanine1405-N7)-methyltransferase

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For detailed information about 16S rRNA (guanine1405-N7)-methyltransferase, go to the full flat file.

Word Map on EC 2.1.1.179

2.1.1.179

aminoglycoside

drug development

esbls

micromonospora

extended-spectrum

carbapenemases

aminoglycoside-resistant

4,6-disubstituted

carbapenem-resistant

plazomicin

methyltranferase

aac6\'-ib

worrisome

carbapenemase-producing

blakpc-2

fosfomycin

blatem-1b

aminoglycoside-producing

deoxystreptamine

tigecycline

mtases

Reaction

Synonyms

16S rRNA (m7G1405) methyltransferase, 16S rRNA methyltransferase, 16S rRNA N7 G1405 methyltransferase, 16S-RMTase, ArmA, FmrO, G1405 methyltransferase ArmA, GrmA, GrmB, Kmr, Krm, M7G1405 MTase, methyltransferase RmtC, methyltransferase Sgm, N7-G1405 16S-RMTase, NbrB, RmtA, RmtB, RmtC, RmtD, RmtD2, RmtF, RmtG, sgm, Sgm methyltransferase, Sgm MTase, sisomicin-gentamicin methylase, sisomicin-gentamicin methyltransferase, sisomicin-gentamicin resistance methylase, Smr1

ECTree

2 Transferases

2.1 Transferring one-carbon groups

2.1.1 Methyltransferases

2.1.1.179 16S rRNA (guanine1405-N7)-methyltransferase

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Results	in table
447	AA Sequence
12	Application
25	Cloned(Commentary)
13	Cofactor
3	Crystallization (Commentary)
41	General Information
1	Inhibitors
5	Molecular Weight [Da]
38	Natural Substrates/ Products (Substrates)
83	Organism
13	PDB ID
3	pH Optimum
40	Protein Variants
7	Purification (Commentary)
3	Reaction
43	Reference
51	Substrates and Products (Substrate)
5	Subunits
92	Synonyms
1	Systematic Name
3	Temperature Optimum [°C]
1	Temperature Stability [°C]

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Systematic Name on EC 2.1.1.179 - 16S rRNA (guanine1405-N7)-methyltransferase

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S-adenosyl-L-methionine:16S rRNA (guanine1405-N7)-methyltransferase

The enzyme from the antibiotic-producing bacterium Micromonospora zionensis specifically methylates guanine1405 at N7 in 16S rRNA, thereby rendering the ribosome resistant to 4,6-disubstituted deoxystreptamine aminoglycosides, which include gentamicins and kanamycins [2].