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2.1.1.179: 16S rRNA (guanine1405-N7)-methyltransferase

This is an abbreviated version!
For detailed information about 16S rRNA (guanine1405-N7)-methyltransferase, go to the full flat file.

Word Map on EC 2.1.1.179

Reaction

S-adenosyl-L-methionine
+
guanine1405 in 16S rRNA
=
S-adenosyl-L-homocysteine
 +
N7-methylguanine1405 in 16S rRNA

Synonyms

16S rRNA (m7G1405) methyltransferase, 16S rRNA methyltransferase, 16S rRNA N7 G1405 methyltransferase, 16S-RMTase, ArmA, FmrO, G1405 methyltransferase ArmA, GrmA, GrmB, Kmr, Krm, M7G1405 MTase, methyltransferase RmtC, methyltransferase Sgm, N7-G1405 16S-RMTase, NbrB, RmtA, RmtB, RmtC, RmtD, RmtD2, RmtF, RmtG, sgm, Sgm methyltransferase, Sgm MTase, sisomicin-gentamicin methylase, sisomicin-gentamicin methyltransferase, sisomicin-gentamicin resistance methylase, Smr1

ECTree

     2 Transferases
         2.1 Transferring one-carbon groups
             2.1.1 Methyltransferases
                2.1.1.179 16S rRNA (guanine1405-N7)-methyltransferase

Reference

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Reference on EC 2.1.1.179 - 16S rRNA (guanine1405-N7)-methyltransferase

Please use the Reference Search for a specific query.
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REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Maravic Vlahovicek, G.; Cubrilo, S.; Tkaczuk, K.L.; Bujnicki, J.M.
Modeling and experimental analyses reveal a two-domain structure and amino acids important for the activity of aminoglycoside resistance methyltransferase Sgm
Biochim. Biophys. Acta
1784
582-590
2008
Micromonospora zionensis (Q7M0R2)
Manually annotated by BRENDA team
Kojic, M.; Topisirovic, L.; Vasiljevic, B.
Cloning and characterization of an aminoglycoside resistance determinant from Micromonospora zionensis
J. Bacteriol.
174
7868-7872
1992
Micromonospora zionensis (Q7M0R2), Micromonospora zionensis
Manually annotated by BRENDA team
Kojic, M.; Topisirovic, L.; Vasiljevic, B.
Translational autoregulation of the sgm gene from Micromonospora zionensis
J. Bacteriol.
178
5493-5498
1996
Micromonospora zionensis (Q7M0R2), Micromonospora zionensis
Manually annotated by BRENDA team
Savic, M.; Ilic-Tomic, T.; Macmaster, R.; Vasiljevic, B.; Conn, G.L.
Critical residues for cofactor binding and catalytic activity in the aminoglycoside resistance methyltransferase Sgm
J. Bacteriol.
190
5855-5861
2008
Micromonospora zionensis (Q7M0R2)
Manually annotated by BRENDA team
Beauclerk, A.A.; Cundliffe, E.
Sites of action of two ribosomal RNA methylases responsible for resistance to aminoglycosides
J. Mol. Biol.
193
661-671
1987
Micromonospora echinospora
Manually annotated by BRENDA team
Savic, M.; Lovric, J.; Tomic, T.I.; Vasiljevic, B.; Conn, G.L.
Determination of the target nucleosides for members of two families of 16S rRNA methyltransferases that confer resistance to partially overlapping groups of aminoglycoside antibiotics
Nucleic Acids Res.
37
5420-5431
2009
Frankia sp. (Q2J7L5), Micromonospora echinospora (Q70KC8), Micromonospora zionensis (Q7M0R2), Frankia sp. CcI3 (Q2J7L5)
Manually annotated by BRENDA team
Husain, N.; Tkaczuk, K.L.; Tulsidas, S.R.; Kaminska, K.H.; Cubrilo, S.; Maravic-Vlahovicek, G.; Bujnicki, J.M.; Sivaraman, J.
Structural basis for the methylation of G1405 in 16S rRNA by aminoglycoside resistance methyltransferase Sgm from an antibiotic producer: a diversity of active sites in m7G methyltransferases
Nucleic Acids Res.
38
4120-4132
2010
Micromonospora zionensis (Q7M0R2), Micromonospora zionensis
Manually annotated by BRENDA team
Tomic, T.I.; Moric, I.; Conn, G.L.; Vasiljevic, B.
Aminoglycoside resistance genes sgm and kgmB protect bacterial but not yeast small ribosomal subunits in vitro despite high conservation of the rRNA A-site
Res. Microbiol.
159
658-662
2008
Micromonospora zionensis (Q7M0R2)
Manually annotated by BRENDA team
Cubrilo, S.; Babic, F.; Douthwaite, S.; Maravic Vlahovicek, G.
The aminoglycoside resistance methyltransferase Sgm impedes RsmF methylation at an adjacent rRNA nucleotide in the ribosomal A site
RNA
15
1492-1497
2009
Micromonospora zionensis (Q7M0R2)
Manually annotated by BRENDA team
Wachino, J.; Yamane, K.; Shibayama, K.; Kurokawa, H.; Shibata, N.; Suzuki, S.; Doi, Y.; Kimura, K.; Ike, Y.; Arakawa, Y.
Novel plasmid-mediated 16S rRNA methylase, RmtC, found in a proteus mirabilis isolate demonstrating extraordinary high-level resistance against various aminoglycosides
Antimicrob. Agents Chemother.
50
178-184
2006
Proteus mirabilis (Q33DX5), Proteus mirabilis ARS68 (Q33DX5)
Manually annotated by BRENDA team
Périchon, B.; Courvalin, P.; Galimand, M.
Transferable resistance to aminoglycosides by methylation of G1405 in 16S rRNA and to hydrophilic fluoroquinolones by QepA-mediated efflux in Escherichia coli
Antimicrob. Agents Chemother.
51
2464-2469
2007
plasmid pIP1206
Manually annotated by BRENDA team
Wachino, J.; Shibayama, K.; Kimura, K.; Yamane, K.; Suzuki, S.; Arakawa, Y.
RmtC introduces G1405 methylation in 16S rRNA and confers high-level aminoglycoside resistance on Gram-positive microorganisms
FEMS Microbiol. Lett.
311
56-60
2010
Proteus mirabilis (Q33DX5), Proteus mirabilis ARS68 (Q33DX5)
Manually annotated by BRENDA team
Liou, G.F.; Yoshizawa, S.; Courvalin, P.; Galimand, M.
Aminoglycoside resistance by ArmA-mediated ribosomal 16S methylation in human bacterial pathogens
J. Mol. Biol.
359
358-364
2006
plasmid pAT780
Manually annotated by BRENDA team
Schmitt, E.; Galimand, M.; Panvert, M.; Courvalin, P.; Mechulam, Y.
Structural bases for 16 S rRNA methylation catalyzed by ArmA and RmtB methyltransferases
J. Mol. Biol.
388
570-582
2009
Escherichia coli
Manually annotated by BRENDA team
Gutierrez, B.; Escudero, J.A.; San Millan, A.; Hidalgo, L.; Carrilero, L.; Ovejero, C.M.; Santos-Lopez, A.; Thomas-Lopez, D.; Gonzalez-Zorn, B.
Fitness cost and interference of Arm/Rmt aminoglycoside resistance with the RsmF housekeeping methyltransferases
Antimicrob. Agents Chemother.
56
2335-2341
2012
Escherichia coli, Escherichia coli BW25113
Manually annotated by BRENDA team
Galimand, M.; Courvalin, P.; Lambert, T.
RmtF, a new member of the aminoglycoside resistance 16S rRNA N7 G1405 methyltransferase family
Antimicrob. Agents Chemother.
56
3960-3962
2012
Klebsiella pneumoniae (I1YZZ5), Klebsiella pneumoniae BM4686 (I1YZZ5), Klebsiella pneumoniae BM4686
Manually annotated by BRENDA team
Wachino, J.; Arakawa, Y.
Exogenously acquired 16S rRNA methyltransferases found in aminoglycoside-resistant pathogenic Gram-negative bacteria: an update
Drug Resist. Updat.
15
133-148
2012
Pseudomonas aeruginosa (A0MK31), Pseudomonas aeruginosa (Q8GRA1), Citrobacter freundii (E9N3S1), Streptoalloteichus hindustanus (O52472), Micromonospora rosea (P24619), Micromonospora olivasterospora (Q08325), Proteus mirabilis (Q33DX5), Micromonospora inyonensis (Q5Y813), Micromonospora echinospora (Q70KC8), Streptomyces kanamyceticus (Q75PS4), Serratia marcescens (Q76G15), Micromonospora zionensis (Q7M0R2), Proteus mirabilis ARS68 (Q33DX5)
Manually annotated by BRENDA team
Correa, L.L.; Witek, M.A.; Zelinskaya, N.; Picao, R.C.; Conn, G.L.
Heterologous expression and functional characterization of the exogenously acquired aminoglycoside resistance methyltransferases RmtD, RmtD2, and RmtG
Antimicrob. Agents Chemother.
60
699-702
2015
Escherichia coli, Micromonospora zionensis (Q7M0R2)
Manually annotated by BRENDA team
Gutierrez, B.; Douthwaite, S.; Gonzalez-Zorn, B.
Indigenous and acquired modifications in the aminoglycoside binding sites of Pseudomonas aeruginosa rRNAs
RNA Biol.
10
1324-1332
2013
Pseudomonas aeruginosa, Pseudomonas aeruginosa BB1285
Manually annotated by BRENDA team
Lioy, V.S.; Goussard, S.; Guerineau, V.; Yoon, E.J.; Courvalin, P.; Galimand, M.; Grillot-Courvalin, C.
Aminoglycoside resistance 16S rRNA methyltransferases block endogenous methylation, affect translation efficiency and fitness of the host
RNA
20
382-391
2014
Escherichia coli, Escherichia coli MM294
Manually annotated by BRENDA team
Nosrati, M.; Dey, D.; Mehrani, A.; Strassler, S.E.; Zelinskaya, N.; Hoffer, E.D.; Stagg, S.M.; Dunham, C.M.; Conn, G.L.
Functionally critical residues in the aminoglycoside resistance-associated methyltransferase RmtC play distinct roles in 30S substrate recognition
J. Biol. Chem.
294
17642-17653
2019
Proteus mirabilis (Q33DX5)
Manually annotated by BRENDA team