2.1.1.179: 16S rRNA (guanine1405-N7)-methyltransferase
This is an abbreviated version!
For detailed information about 16S rRNA (guanine1405-N7)-methyltransferase, go to the full flat file.
Word Map on EC 2.1.1.179
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2.1.1.179
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aminoglycoside
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drug development
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esbls
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micromonospora
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extended-spectrum
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carbapenemases
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aminoglycoside-resistant
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4,6-disubstituted
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carbapenem-resistant
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plazomicin
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methyltranferase
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aac6\'-ib
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worrisome
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carbapenemase-producing
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blakpc-2
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fosfomycin
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blatem-1b
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aminoglycoside-producing
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deoxystreptamine
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tigecycline
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mtases
- 2.1.1.179
- aminoglycoside
- drug development
-
esbls
- micromonospora
-
extended-spectrum
- carbapenemases
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aminoglycoside-resistant
-
4,6-disubstituted
-
carbapenem-resistant
-
plazomicin
-
methyltranferase
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aac6\'-ib
-
worrisome
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carbapenemase-producing
- blakpc-2
- fosfomycin
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blatem-1b
-
aminoglycoside-producing
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deoxystreptamine
- tigecycline
- mtases
Reaction
Synonyms
16S rRNA (m7G1405) methyltransferase, 16S rRNA methyltransferase, 16S rRNA N7 G1405 methyltransferase, 16S-RMTase, ArmA, FmrO, G1405 methyltransferase ArmA, GrmA, GrmB, Kmr, Krm, M7G1405 MTase, methyltransferase RmtC, methyltransferase Sgm, N7-G1405 16S-RMTase, NbrB, RmtA, RmtB, RmtC, RmtD, RmtD2, RmtF, RmtG, sgm, Sgm methyltransferase, Sgm MTase, sisomicin-gentamicin methylase, sisomicin-gentamicin methyltransferase, sisomicin-gentamicin resistance methylase, Smr1
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General Information
General Information on EC 2.1.1.179 - 16S rRNA (guanine1405-N7)-methyltransferase
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evolution
physiological function
additional information
FmrO shows intrinsic N7-G1405 16S-RMTase activity
evolution
RmtA shows aquired N7-G1405 16S-RMTase activity
evolution
RmtD shows aquired N7-G1405 16S-RMTase activity
evolution
RmtF is a member of the aminoglycoside resistance 16S rRNA N7 G1405 methyltransferase family
evolution
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RmtF is a member of the aminoglycoside resistance 16S rRNA N7 G1405 methyltransferase family
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encodes an enzyme that modifies 16S rRNA and thereby confers resistance to 4,6-disubstituted deoxystreptamine aminoglycosides. The expression of the sgm gene is regulated by the translational autorepression
physiological function
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the enzyme gives resistance to kanamycin plus gentamicin by converting guanine1405 to 7-methylguanine
physiological function
the enzyme produced by the antibiotic-producing bacterium Micromonospora zionensis methylates guanine1405 in 16S rRNA to 7-methylguanine, thereby rendering the ribosome resistant to 4,6-disubstituted deoxystreptamine aminoglycosides, which include gentamicins and kanamycins
physiological function
plasmid pAT780
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G1405 methylation produces aminoglycoside resistance by diminishing the affinity of the ribosome for gentamicin
physiological function
rmtC is responsible for resistance of strain ARS68 and its transformant to various aminoglycoside antibiotics
physiological function
methylation of C1405, involved in the binding of aminoglycosides to 16S rRNA, can lead to loss of affinity and to resistance of the host. Resistance conferred by RmtF cannot be transferred to Escherichia coli via transfer of plasmid pIP849
physiological function
most aminoglycosides bind to the decoding aminoacyl-tRNA recognition site (A-site) of the 16S rRNA that composes bacterial 30S ribosome, and subsequently interfere with bacterial growth through blocking of protein synthesis, These aminoglycoside-producing actinomycetes are inherently resistant to aminoglycosides, because they harbor intrinsic 16S rRNA methyltransferase genes, that can confer aminoglycoside resistance to bacteria by modifying specific nucleotide residues in the aminoglycoside binding site of 16S rRNA. Aminoglycoside resistance profile provided by N7-G1405 16S-RMTases, overview
physiological function
most aminoglycosides bind to the decoding aminoacyl-tRNA recognition site (A-site) of the 16S rRNA that composes bacterial 30S ribosome, and subsequently interfere with bacterial growth through blocking of protein synthesis. These aminoglycoside-producing actinomycetes are inherently resistant to aminoglycosides, because they harbor intrinsic 16S rRNA methyltransferase genes, that can confer aminoglycoside resistance to bacteria by modifying specific nucleotide residues in the aminoglycoside binding site of 16S rRNA. Aminoglycoside resistance profile provided by N7-G1405 16S-RMTases, overview
physiological function
most aminoglycosides bind to the decoding aminoacyl-tRNA recognition site (A-site) of the 16S rRNA that composes bacterial 30S ribosome, and subsequently interfere with bacterial growth through blocking of protein synthesis. These aminoglycoside-producing actinomycetes are inherently resistant to aminoglycosides, because they harbor intrinsic 16S rRNA methyltransferase genes, that can confer aminoglycoside resistance to bacteria by modifying specific nucleotide residues in the aminoglycoside binding site of 16S rRNA. Aminoglycoside resistance profile provided by N7-G1405 16S-RMTases, overview
physiological function
most aminoglycosides bind to the decoding aminoacyl-tRNA recognition site (A-site) of the 16S rRNA that composes bacterial 30S ribosome, and subsequently interfere with bacterial growth through blocking of protein synthesis. These aminoglycoside-producing actinomycetes are inherently resistant to aminoglycosides, because they harbor intrinsic 16S rRNA methyltransferase genes, that can confer aminoglycoside resistance to bacteria by modifying specific nucleotide residues in the aminoglycoside binding site of 16S rRNA. Aminoglycoside resistance profile provided by N7-G1405 16S-RMTases, overview
physiological function
most aminoglycosides bind to the decoding aminoacyl-tRNA recognition site (A-site) of the 16S rRNA that composes bacterial 30S ribosome, and subsequently interfere with bacterial growth through blocking of protein synthesis. These aminoglycoside-producing actinomycetes are inherently resistant to aminoglycosides, because they harbor intrinsic 16S rRNA methyltransferase genes, that can confer aminoglycoside resistance to bacteria by modifying specific nucleotide residues in the aminoglycoside binding site of 16S rRNA. Aminoglycoside resistance profile provided by N7-G1405 16S-RMTases, overview
physiological function
most aminoglycosides bind to the decoding aminoacyl-tRNA recognition site (A-site) of the 16S rRNA that composes bacterial 30S ribosome, and subsequently interfere with bacterial growth through blocking of protein synthesis. These aminoglycoside-producing actinomycetes are inherently resistant to aminoglycosides, because they harbor intrinsic 16S rRNA methyltransferase genes, that can confer aminoglycoside resistance to bacteria by modifying specific nucleotide residues in the aminoglycoside binding site of 16S rRNA. Aminoglycoside resistance profile provided by N7-G1405 16S-RMTases, overview
physiological function
most aminoglycosides bind to the decoding aminoacyl-tRNA recognition site (A-site) of the 16S rRNA that composes bacterial 30S ribosome, and subsequently interfere with bacterial growth through blocking of protein synthesis. These aminoglycoside-producing actinomycetes are inherently resistant to aminoglycosides, because they harbor intrinsic 16S rRNA methyltransferase genes, that can confer aminoglycoside resistance to bacteria by modifying specific nucleotide residues in the aminoglycoside binding site of 16S rRNA. Aminoglycoside resistance profile provided by N7-G1405 16S-RMTases, overview
physiological function
the enzyme adds the methyl group of S-adenosyl-L-methionine to the specific nucleotides at the A-site of 16S rRNA, which interferes with aminoglycoside binding to the target. Aminoglycoside resistance profile provided by N7-G1405 16S-RMTases, overview
physiological function
the enzyme adds the methyl group of S-adenosyl-L-methionine to the specific nucleotides at the A-site of 16S rRNA, which interferes with aminoglycoside binding to the target. Aminoglycoside resistance profile provided by N7-G1405 16S-RMTases, overview
physiological function
the enzyme adds the methyl group of S-adenosyl-L-methionine to the specific nucleotides at the A-site of 16S rRNA, which interferes with aminoglycoside binding to the target. Aminoglycoside resistance profile provided by N7-G1405 16S-RMTases, overview
physiological function
the enzyme adds the methyl group of S-adenosyl-L-methionine to the specific nucleotides at the A-site of 16S rRNA, which interferes with aminoglycoside binding to the target. Pseudomonas aeruginosa clinical isolates show high-level resistance to clinically useful aminoglycosides through the production of acquired 16S-RMTase. Aminoglycoside resistance profile provided by N7-G1405 16S-RMTases, overview
physiological function
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the enzyme confers high-level resistance to 4,6-disubstituted aminoglycosides through methylation of the G1405 residue in the 16S rRNA. RmtC impedes methylation by the housekeeping methyltransferase RsmF, EC 2.1.1.178, at position C1407
physiological function
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the enzyme confers high-level resistance to aminoglycosides
physiological function
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methylation of C1405, involved in the binding of aminoglycosides to 16S rRNA, can lead to loss of affinity and to resistance of the host. Resistance conferred by RmtF cannot be transferred to Escherichia coli via transfer of plasmid pIP849
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physiological function
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the enzyme confers high-level resistance to 4,6-disubstituted aminoglycosides through methylation of the G1405 residue in the 16S rRNA. RmtC impedes methylation by the housekeeping methyltransferase RsmF, EC 2.1.1.178, at position C1407
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physiological function
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rmtC is responsible for resistance of strain ARS68 and its transformant to various aminoglycoside antibiotics
-
physiological function
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the enzyme adds the methyl group of S-adenosyl-L-methionine to the specific nucleotides at the A-site of 16S rRNA, which interferes with aminoglycoside binding to the target. Aminoglycoside resistance profile provided by N7-G1405 16S-RMTases, overview
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physiological function
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the enzyme confers high-level resistance to aminoglycosides
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acquisition of rmtC does not entail a fitness cost for the bacterium
additional information
GrmA shows intrinsic N7-G1405 16S-RMTase activity
additional information
GrmB shows intrinsic N7-G1405 16S-RMTase activity
additional information
Kmr shows intrinsic N7-G1405 16S-RMTase activity
additional information
NbrB shows intrinsic N7-G1405 16S-RMTase activity
additional information
Sgm shows intrinsic N7-G1405 16S-RMTase activity
additional information
Smr1 shows intrinsic N7-G1405 16S-RMTase activity
additional information
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acquisition of rmtC does not entail a fitness cost for the bacterium
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