2.1.1.177: 23S rRNA (pseudouridine1915-N3)-methyltransferase

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For detailed information about 23S rRNA (pseudouridine1915-N3)-methyltransferase, go to the full flat file.

Reaction

Synonyms

m3Psi methyltransferase, pseudouridine methyltransferase, Psi1915-specific methyltransferase, RlmH, rRNA large subunit methyltransferase H, YbeA

ECTree

     2 Transferases

         2.1 Transferring one-carbon groups

             2.1.1 Methyltransferases

                2.1.1.177 23S rRNA (pseudouridine1915-N3)-methyltransferase

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Results	in table
26171	AA Sequence
1	Cloned(Commentary)
1	Crystallization (Commentary)
3	General Information
1	Inhibitors
3	kcat/KM [mM/s]
3	KM Value [mM]
1	Molecular Weight [Da]
2	Natural Substrates/ Products (Substrates)
4	Organism
21	PDB ID
1	pH Optimum
7	Protein Variants
1	Purification (Commentary)
2	Reaction
4	Reference
4	Substrates and Products (Substrate)
2	Subunits
11	Synonyms
1	Systematic Name
1	Temperature Optimum [°C]
3	Turnover Number [1/s]

Substrates Products

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Substrates Products on EC 2.1.1.177 - 23S rRNA (pseudouridine1915-N3)-methyltransferase

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SUBSTRATE

PRODUCT                       

REACTION DIAGRAM

ORGANISM

UNIPROT

COMMENTARY
(Substrate)

LITERATURE
(Substrate)

COMMENTARY
(Product)

LITERATURE
(Product)

Reversibility
r=reversible
ir=irreversible
?=not specified

S-adenosyl-L-methionine + pseudouridine1915 in 23S rRNA

S-adenosyl-L-homocysteine + N3-methylpseudouridine1915 in 23S rRNA

3 entries

S-adenosyl-L-methionine + pseudouridine1915 in 23S rRNA

S-adenosyl-L-homocysteine + N3-methylpseudouridine1915 in 23S rRNA

Escherichia coli

P0A8I8

-

706719, 758415

-

-

?

S-adenosyl-L-methionine + pseudouridine1915 in 23S rRNA

S-adenosyl-L-homocysteine + N3-methylpseudouridine1915 in 23S rRNA

Escherichia coli

P0A8I8

YbeA is acting at the final stage during ribosome assembly, probably during translation initiation

706718

-

-

?

S-adenosyl-L-methionine + pseudouridine1915 in 23S rRNA

S-adenosyl-L-homocysteine + N3-methylpseudouridine1915 in 23S rRNA

Escherichia coli

P0A8I8

pseudouridine is the preferred substrate, inability of YbeA to methylate uridine at position 1915. The enzyme requires the intact ribosome and the presence of pseudouridine at position 1915 in 23S rRNA for activity

706718

-

-

?