2.1.1.169: tricetin 3',4',5'-O-trimethyltransferase
This is an abbreviated version!
For detailed information about tricetin 3',4',5'-O-trimethyltransferase, go to the full flat file.
Reaction
3 S-adenosyl-L-methionine + = 3 S-adenosyl-L-homocysteine +
Synonyms
FOMT, O-methyltransferase, OMT2, TaCOMT1, TaOMT, TaOMT2
ECTree
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Reaction
Reaction on EC 2.1.1.169 - tricetin 3',4',5'-O-trimethyltransferase
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3 S-adenosyl-L-methionine + tricetin = 3 S-adenosyl-L-homocysteine + 3',4',5'-O-trimethyltricetin
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S-adenosyl-L-methionine + 3',5'-O-dimethyltricetin = S-adenosyl-L-homocysteine + 3',4',5'-O-trimethyltricetin
S-adenosyl-L-methionine + 3'-hydroxyflavone = S-adenosyl-L-homocysteine + 3'-methoxyflavone
S-adenosyl-L-methionine + 3'-O-methyltricetin = S-adenosyl-L-homocysteine + 3',5'-O-dimethyltricetin
S-adenosyl-L-methionine + 3',5'-O-dimethyltricetin = S-adenosyl-L-homocysteine + 3',4',5'-O-trimethyltricetin
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S-adenosyl-L-methionine + 3',5'-O-dimethyltricetin = S-adenosyl-L-homocysteine + 3',4',5'-O-trimethyltricetin
mechanism for the sequential methylation of tricetin, overview
unique structural features of TaOMT2 which permit the stepwise methylation of tricetin is disclosed. Substrate binding is mediated by an extensive network of H-bonds and van der Waals interactions. The partly buried tricetin active site, as well as proximity and orientation effects ensure sequential methylation of the substrate within the same pocket. Stepwise methylation of tricetin involves deprotonation of its hydroxyl groups by a His262-Asp263 pair followed by nucleophilic attack of SAM-methyl groups
S-adenosyl-L-methionine + 3'-O-methyltricetin = S-adenosyl-L-homocysteine + 3',5'-O-dimethyltricetin
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S-adenosyl-L-methionine + 3'-O-methyltricetin = S-adenosyl-L-homocysteine + 3',5'-O-dimethyltricetin
mechanism for the sequential methylation of tricetin, overview
S-adenosyl-L-methionine + tricetin = S-adenosyl-L-homocysteine + 3'-O-methyltricetin
mechanism for the sequential methylation of tricetin, overview