2.1.1.169: tricetin 3',4',5'-O-trimethyltransferase
This is an abbreviated version!
For detailed information about tricetin 3',4',5'-O-trimethyltransferase, go to the full flat file.
Word Map on EC 2.1.1.169
Reaction
3 S-adenosyl-L-methionine
+
Synonyms
FOMT, O-methyltransferase, OMT2, TaCOMT1, TaOMT, TaOMT2
ECTree
2.1.1.169 tricetin 3',4',5'-O-trimethyltransferaseAdvanced search results
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results (Natural Substrates Products
Natural Substrates Products on EC 2.1.1.169 - tricetin 3',4',5'-O-trimethyltransferase
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NATURAL SUBSTRATE 
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
S-adenosyl-L-methionine + 3',5'-O-dimethyltricetin
S-adenosyl-L-homocysteine + 3',4',5'-O-trimethyltricetin
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-
-
?
S-adenosyl-L-methionine + 3'-O-methyltricetin
S-adenosyl-L-homocysteine + 3',5'-O-dimethyltricetin
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-
-
?
S-adenosyl-L-methionine + tricetin
S-adenosyl-L-homocysteine + 3',4',5'-O-trimethyltricetin
i.e. 5,7,3',4',5'-pentahydroxyflavone, most preferred substrate
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-
?
S-adenosyl-L-methionine + tricetin
S-adenosyl-L-homocysteine + 3'-O-methyltricetin
-
-
-
?
additional information
?
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stepwise methylation of tricetin involving deprotonation of its hydroxyl groups by a His262-Asp263 pair followed by nucleophilic attack of SAM-methyl groups, substrate binding is mediated by an extensive network of H-bonds and van der Waals interactions, residue Val309 determines substrate specificity for tricetin and may define the evolutionary differences between the two closely related proteins, COMT and flavone OMT, molecular modeling, overview
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-
?
additional information
?
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stepwise methylation of tricetin involving deprotonation of its hydroxyl groups by a His262-Asp263 pair followed by nucleophilic attack of SAM-methyl groups, substrate binding is mediated by an extensive network of H-bonds and van der Waals interactions, residue Val309 determines substrate specificity for tricetin and may define the evolutionary differences between the two closely related proteins, COMT and flavone OMT, molecular modeling, overview
-
-
?
