2.1.1.167: 27S pre-rRNA (guanosine2922-2'-O)-methyltransferase
This is an abbreviated version!
For detailed information about 27S pre-rRNA (guanosine2922-2'-O)-methyltransferase, go to the full flat file.
Word Map on EC 2.1.1.167
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2.1.1.167
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rrnas
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nucleolar
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2'-o-ribose
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pre-ribosomal
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coimmunoprecipitation
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cold-sensitive
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methyltransferases
- 2.1.1.167
- rrnas
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nucleolar
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2'-o-ribose
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pre-ribosomal
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coimmunoprecipitation
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cold-sensitive
- methyltransferases
Reaction
Synonyms
Spb1p
ECTree
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Natural Substrates Products
Natural Substrates Products on EC 2.1.1.167 - 27S pre-rRNA (guanosine2922-2'-O)-methyltransferase
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REACTION DIAGRAM
S-adenosyl-L-methionine + guanosine2922 in 27S pre-rRNA
S-adenosyl-L-homocysteine + 2'-O-methylguanosine2922 in 27S pre-rRNA
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Spb1p is a site-specific 2'-O-ribose RNA MTase that catalyzes the formation of Gm2922, a universally conserved position of the catalytic center of the ribosome that is essential for translation. The enzyme is required for proper assembly of pre-ribosomal particles during the biogenesis of the 60S ribosomal subunit. Specifically methylates the guanosine in position 2922 of the 25S rRNA at the stage of 27S pre-rRNA maturation. Methylates also the uridine in position 2921 in the absence of methylation of this residue guided by snoRNA snR52 at the stage of 35S pre-rRNA maturation. 2'-O-methylguanosine2922 appears at a late processing stage, during the maturation of the 27S pre-rRNA
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S-adenosyl-L-methionine + uridine2918 in 25S rRNA
S-adenosyl-L-homocysteine + 2'-O-methyluridine2918 in 25S rRNA
S-adenosyl-L-homocysteine + 2'-O-methyluridine2918 in 25S rRNA
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the enzyme is required for proper assembly of pre-ribosomal particles during the biogenesis of the 60S ribosomal subunit. Specifically methylates the guanosine in position 2922 of the 25S rRNA at the stage of 27S pre-rRNA maturation. Methylates also the uridine in position 2921 in the absence of methylation of this residue guided by snoRNA snR52 at the stage of 35S pre-rRNA maturation
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S-adenosyl-L-methionine + uridine2918 in 25S rRNA
S-adenosyl-L-homocysteine + 2'-O-methyluridine2918 in 25S rRNA
the enzyme is required for proper assembly of pre-ribosomal particles during the biogenesis of the 60S ribosomal subunit. Specifically methylates the guanosine in position 2922 of the 25S rRNA at the stage of 27S pre-rRNA maturation. Methylates also the uridine in position 2921 in the absence of methylation of this residue guided by snoRNA snR52 at the stage of 35S pre-rRNA maturation
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Spb1p is required for proper assembly of pre-ribosomal particles during the biogenesis of 60S ribosomal subunits
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additional information
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Spb1p is required for proper assembly of pre-ribosomal particles during the biogenesis of 60S ribosomal subunits
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