2.1.1.159: theobromine synthase
This is an abbreviated version!
For detailed information about theobromine synthase, go to the full flat file.
Word Map on EC 2.1.1.159
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2.1.1.159
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purine
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camellia
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xanthosine
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coffea
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1,3,7-trimethylxanthine
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arabica
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n-methyltransferases
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caffeine-free
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rnai
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food industry
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planta
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canephora
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germplasms
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sinensis
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biotechnology
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agriculture
- 2.1.1.159
- purine
- camellia
- xanthosine
- coffea
- 1,3,7-trimethylxanthine
- arabica
- n-methyltransferases
-
caffeine-free
- rnai
- food industry
-
planta
- canephora
-
germplasms
- sinensis
- biotechnology
- agriculture
Reaction
Synonyms
3,7-dimethylxanthine methyltransferase, 3-N-methyltransferase, 3NMT, 7-methylxanthine 3-N-methyltransferase, 7-methylxanthine methyltransferase, 7-methylxanthine N-methyltransferase, caffeine synthase, caffeine synthase 1, CCS1, coffee caffeine synthase 1, CS, CtCS6, CTS, CTS1, CTS2, DXMT, DXMT1, MXMT, MXMT1, MXMT2, N-3 methyltransferase, N-methyltransferase, TCS1, theobromine synthase 2
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Reference on EC 2.1.1.159 - theobromine synthase
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REF. 
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Koshiishi, C.; Kato, A.; Yama, S.; Crozier, A.; Ashihara, H.
A new caffeine biosynthetic pathway in tea leaves: utilisation of adenosine released from the S-adenosyl-L-methionine cycle
FEBS Lett.
499
50-54
2001
Camellia sinensis
McCarthy, A.A.; Biget, L.; Lin, C.; Petiard, V.; Tanksley, S.D.; McCarthy, J.G.
Cloning, expression, crystallization and preliminary x-ray analysis of the XMT and DXMT N-methyltransferases from Coffea canephora (robusta)
Acta Crystallogr. Sect. F
F63
304-307
2007
Coffea canephora (A4GE70)
Mizuno, K.; Okuda, A.; Kato, M.; Yoneyama, N.; Tanaka, H.; Ashihara, H.; Fujimura, T.
Isolation of a new dual-functional caffeine synthase gene encoding an enzyme for the conversion of 7-methylxanthine to caffeine from coffee (Coffea arabica L.)
FEBS Lett.
534
75-81
2003
Coffea arabica (Q8H0D3)
Ogawa, M.; Herai, Y.; Koizumi, N.; Kusano, T.; Sano, H.
7-Methylxanthine methyltransferase of coffee plants. Gene isolation and enzymatic properties
J. Biol. Chem.
276
8213-8218
2001
Coffea arabica (Q9AVJ9), Coffea arabica (Q9AVK1)
Kato, M.; Mizuno, K.; Crozier, A.; Fujimura, T.; Ashihara, H.
Caffeine synthase gene from tea leaves
Nature
406
956-957
2000
Camellia sinensis (Q9FZN8)
Roberts, M.F.; Waller, G.R.
N-methyltransferases and 7-methyl-N9-nucleoside hydrolase activity in Coffea arabica and the biosynthesis of caffeine
Phytochemistry
18
451-455
1979
Coffea arabica
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Waldhauser, S.S.M.; Gillies, F.M.; Crozier, A.; Baumann, T.W.
Separation of the N-7 methyltransferase, the key enzyme in caffeine biosynthesis
Phytochemistry
45
1407-1414
1997
Coffea arabica
Ogita, S.; Uefuji, H.; Morimoto, M.; Sano, H.
Application of RNAi to confirm theobromine as the major intermediate for caffeine biosynthesis in coffee plants with potential for construction of decaffeinated varieties
Plant Mol. Biol.
54
931-941
2004
Coffea canephora, Coffea arabica (Q84PP7), Coffea arabica (Q9AVJ9), Coffea arabica
Uefuji, H.; Tatsumi, Y.; Morimoto, M.; Kaothien-Nakayama, P.; Ogita, S.; Sano, H.
Caffeine production in tobacco plants by simultaneous expression of three coffee N-methyltranferases and its potential as a pest repellant
Plant Mol. Biol.
59
221-227
2005
Coffea arabica (Q9AVJ9)
Kato, M.; Mizuno, K.; Fujimura, T.; Iwama, M.; Irie, M.; Crozier, A.; Ashihara, H.
Purification and characterization of caffeine synthase from tea leaves
Plant Physiol.
120
579-586
1999
Camellia sinensis
Uefuji, H.; Ogita, S.; Yamaguchi, Y.; Koizumi, N.; Sano, H.
Molecular cloning and functional characterization of three distinct N-methyltransferases involved in the caffeine biosynthetic pathway in coffee plants
Plant Physiol.
132
372-380
2003
Coffea arabica (Q84PP7), Coffea arabica (Q9AVJ9)
McCarthy, A.A.; McCarthy, J.G.
The structure of two N-methyltransferases from the caffeine biosynthetic pathway
Plant Physiol.
144
879-889
2007
Coffea canephora
Koshiro, Y.; Zheng, X.Q.; Wang, M.L.; Nagai, C.; Ashihara, H.
Changes in content and biosynthetic activity of caffeine and trigonelline during growth and ripening of Coffea arabica and Coffea canephora fruits
Plant Sci.
171
242-250
2006
Coffea canephora, Coffea arabica (Q8H0G0)
Kodama, Y.; Shinya, T.; Sano, H.
Dimerization of N-methyltransferases involved in caffeine biosynthesis
Biochimie
90
547-551
2008
Coffea arabica
Maluf, M.; Da Silva, C.; De Oliveira, M.; Tavares, A.; Silvarolla, M.; Guerreiro Filho, O.
Altered expression of the caffeine synthase gene in a naturally caffeine-free mutant of Coffea arabica
Genet. Mol. Biol.
32
802-810
2009
Coffea arabica (Q8H0G0), Coffea arabica
Ishida, M.; Kitao, N.; Mizuno, K.; Tanikawa, N.; Kato, M.
Occurrence of theobromine synthase genes in purine alkaloid-free species of Camellia plants
Planta
229
559-568
2009
Camellia japonica (B6ZGN6), Camellia granthamiana (B6ZH67), Camellia granthamiana (B6ZH68), Camellia kissii (B6ZH69), Camellia lutchuensis (B6ZH70), Camellia petelotii (B6ZH71)
Mizuno, K.; Kurosawa, S.; Yoshizawa, Y.; Kato, M.
Essential region for 3-N methylation in N-methyltransferases involved in caffeine biosynthesis
Z. Naturforsch. C
65c
257-265
2010
Coffea sp.
Mohanan, S.; Gowda, K.; Kandukuri, S.V.; Chandrashekar, A.
Involvement of a novel intronic microRNA in cross regulation of N-methyltransferase genes involved in caffeine biosynthesis in Coffea canephora
Gene
519
107-112
2013
Coffea canephora
Schimpl, F.C.; Kiyota, E.; Mayer, J.L.; Goncalves, J.F.; da Silva, J.F.; Mazzafera, P.
Molecular and biochemical characterization of caffeine synthase and purine alkaloid concentration in guarana fruit
Phytochemistry
105
25-36
2014
Paullinia cupana
Jin, L.; Bhuiya, M.W.; Li, M.; Liu, X.; Han, J.; Deng, W.; Wang, M.; Yu, O.; Zhang, Z.
Metabolic engineering of Saccharomyces cerevisiae for caffeine and theobromine production
PLoS ONE
9
e105368
2014
Camellia sinensis (Q9FZN8)
Teng, J.; Yan, C.; Zeng, W.; Zhang, Y.; Zeng, Z.; Huang, Y.
Purification and characterization of theobromine synthase in a Theobromine-Enriched wild tea plant (Camellia gymnogyna Chang) from Dayao Mountain, China
Food Chem.
311
125875
2020
Camellia gymnogyna
Kumar, A.; Giridhar, P.
Salicylic acid and methyljasmonate restore the transcription of caffeine biosynthetic N-methyltransferases from a transcription inhibition noticed during late endosperm maturation in coffee
Plant Gene
4
38-44
2015
Coffea canephora, Coffea canephora var. robusta
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