2.1.1.157: sarcosine/dimethylglycine N-methyltransferase

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For detailed information about sarcosine/dimethylglycine N-methyltransferase, go to the full flat file.

Reaction

2 S-adenosyl-L-methionine +

Synonyms

dimethylglycine methyltransferase, DMT, DMT2, glycine sarcosine dimethylglycine methyltransferase, glycine sarcosine methyltransferase, GSDMT, GsSDMT, MXAN 3190, sarcosine dimethylglycine methyltransferas, sarcosine dimethylglycine methyltransferase, sarcosine dimethylglycine N-methyltransferase, Sdm, Sdm homologue protein, SdmA, SDMT

ECTree

     2 Transferases

         2.1 Transferring one-carbon groups

             2.1.1 Methyltransferases

                2.1.1.157 sarcosine/dimethylglycine N-methyltransferase

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Results	in table
1	Activating Compound
256	AA Sequence
3	Application
1	CAS Registry Number
11	Cloned(Commentary)
2	Cofactor
2	Crystallization (Commentary)
3	Expression
8	General Information
2	IC50 Value
23	Inhibitors
22	KM Value [mM]
3	Metals/Ions
12	Molecular Weight [Da]
32	Natural Substrates/ Products (Substrates)
18	Organism
4	Pathway
9	pH Optimum
1	pI Value
4	Protein Variants
6	Purification (Commentary)
6	Reaction
17	Reference
11	Specific Activity [micromol/min/mg]
1	Storage Stability
50	Substrates and Products (Substrate)
8	Subunits
34	Synonyms
1	Systematic Name
5	Temperature Optimum [°C]
1	Temperature Stability [°C]
4	Turnover Number [1/s]

Systematic Name

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Systematic Name on EC 2.1.1.157 - sarcosine/dimethylglycine N-methyltransferase

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SYSTEMATIC NAME

IUBMB Comments

S-adenosyl-L-methionine:sarcosine(or N,N-dimethylglycine) N-methyltransferase [N,N-dimethylglycine(or betaine)-forming]

Cells of the oxygen-evolving halotolerant cyanobacterium Aphanocthece halophytica synthesize betaine from glycine by a three-step methylation process. The first enzyme, EC 2.1.1.156, glycine/sarcosine N-methyltransferase, leads to the formation of either sarcosine or N,N-dimethylglycine, which is further methylated to yield betaine (N,N,N-trimethylglycine) by the action of this enzyme. Both of these enzymes can catalyse the formation of N,N-dimethylglycine from sarcosine [3]. The reactions are strongly inhibited by S-adenosyl-L-homocysteine.