2.1.1.155: kaempferol 4'-O-methyltransferase
This is an abbreviated version!
For detailed information about kaempferol 4'-O-methyltransferase, go to the full flat file.
Reaction
Synonyms
4'OMT, CrOMT6, F 4’-OMT, flavonoid methyltransferase, flavonoid O-methyltransferase, methyltransferase, flavonoid, S-adenosyl-L-methionine:flavonoid 4’-O-methyltransferase
ECTree
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Substrates Products
Substrates Products on EC 2.1.1.155 - kaempferol 4'-O-methyltransferase
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REACTION DIAGRAM
S-adenosyl-L-methionine + 4'-hydroxyflavanone
S-adenosyl-L-homocysteine + 4'-methoxyflavanone
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-
-
-
?
S-adenosyl-L-methionine + apigenin
S-adenosyl-L-homocysteine + acacetin
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-
4Â’-methoxyapigenin
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?
S-adenosyl-L-methionine + chrysoeriol
S-adenosyl-L-homocysteine + 4'-methoxychrysoeriol
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good substrate
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-
?
S-adenosyl-L-methionine + eriodictyol
S-adenosyl-L-homocysteine + 4'-methoxyeriodictyol
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lower activity than with homoeriodictyol, isorhamnetin or chrysoeriol
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-
?
S-adenosyl-L-methionine + genistein
S-adenosyl-L-homocysteine + biochanin A
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-
4Â’-methoxygenistein
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?
S-adenosyl-L-methionine + homoeriodictyol
S-adenosyl-L-homocysteine + 4'-methoxyhomoeriodictyol
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best substrate
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-
?
S-adenosyl-L-methionine + isorhamnetin
S-adenosyl-L-homocysteine + 4'-methoxyisorhamnetin
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good substrate
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-
?
S-adenosyl-L-methionine + kaempferol 3-O-beta-D-glucopyranosyl-1,4-O-alpha-L-rhamnopyranosyl-1,2-beta-D-glucopyranoside
S-adenosyl-L-homocysteine + 4'-O-methylkaempferol 3-O-beta-D-glucopyranosyl-1,4-O-alpha-L-rhamnopyranosyl-1,2-beta-D-glucopyranoside
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-
-
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?
S-adenosyl-L-methionine + quercetin
S-adenosyl-L-homocysteine + 4'-methoxyquercetin
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lower activity than with homoeriodictyol, isorhamnetin or chrysoeriol
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-
?
S-adenosyl-L-homocysteine + a 4'-methoxyflavonoid
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4Â’-OMT methylates the position 4Â’ in the B-ring of flavonoids, uses flavonoids methylated in the 3Â’-position of the B-ring to synthesize a 3Â’,4Â’-methylated product, a methylated flavanone, homoeriodictyol, is the best substrate
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-
?
S-adenosyl-L-methionine + a flavonoid
S-adenosyl-L-homocysteine + a 4'-methoxyflavonoid
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F 4Â’-OMT specifically methylates the hydroxy substituent in 4Â’-position of the flavones, flavanones and isoflavones in the presence of S-adenosyl-L-methionine, enzyme affinity for the substrate and catalytic efficiency decreases in the following order: 4Â’-hydroxyflavones, 4Â’-hydroxyflavanones, 4Â’-hydroxyisoflavones, ping-pong mechanism, which excludes the formation of a ternary complex
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?
S-adenosyl-L-homocysteine + kaempferide
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lower activity than with homoeriodictyol, isorhamnetin or chrysoeriol
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-
?
S-adenosyl-L-methionine + kaempferol
S-adenosyl-L-homocysteine + kaempferide
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-
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?
?
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not: naringenin, pentahydroxyflavanone, hesperetin, myricetin, 7,3Â’-O-dimethylquercetin, 7-O-methylquercetin, syringetin, apigenin, luteolin, tricetin, velutin, dihydrokaempferol, dihydroquercetin, dihydromyricetin, 3Â’-O-methyl-dihydroquercetin
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-
?
additional information
?
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the role of F 4Â’-OMT is mainly defensive against parasites, rather than structural
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?
additional information
?
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not: 4-hydroxybenzoic acid, gallic acid, p-coumaric acid, caffeic acid, caffeoyl-CoA, quercetin, rutin, luteolin, eriodictyol, 3Â’,4Â’,7Â’-trihydroxyisoflavone, datiscetin
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?