2.1.1.151: cobalt-factor II C20-methyltransferase
This is an abbreviated version!
For detailed information about cobalt-factor II C20-methyltransferase, go to the full flat file.
Reaction
Synonyms
20-methyl transferase of corrin biosynthesis, CbiL, cbiL gene product, M-2, precorrin-2 methyltransferase
ECTree
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Reaction
Reaction on EC 2.1.1.151 - cobalt-factor II C20-methyltransferase
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S-adenosyl-L-methionine + cobalt-factor II = S-adenosyl-L-homocysteine + cobalt-factor III
Involved in the anaerobic biosynthesis of vitamin B12
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S-adenosyl-L-methionine + cobalt-factor II = S-adenosyl-L-homocysteine + cobalt-factor III
Gly11, Gly103 and Asp104 involved in S-adenosyl-L-methionine binding
S-adenosyl-L-methionine + cobalt-factor II = S-adenosyl-L-homocysteine + cobalt-factor III
the conserved Tyr226 residue in CbiL catalyzes the direct transfer of a methyl group from S-adenosylmethionine to the substrate through an SN2-like mechanism, S-adenosyl-L-homocysteine binds to Pro14, Asp106, Phe109, Ala135, and Val205, as well as to Val104 and Phe136 via a water molecule
S-adenosyl-L-methionine + cobalt-factor II = S-adenosyl-L-homocysteine + cobalt-factor III
the conserved Tyr226 residue in CbiL catalyzes the direct transfer of a methyl group from S-adenosylmethionine to the substrate through an SN2-like mechanism, S-adenosyl-L-homocysteine binds to Pro14, Asp106, Phe109, Ala135, and Val205, as well as to Val104 and Phe136 via a water molecule
Chlorobaculum tepidum ATCC 49652
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