2.1.1.148: thymidylate synthase (FAD)

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For detailed information about thymidylate synthase (FAD), go to the full flat file.

Reaction

Synonyms

A674R, complementing thymidylate synthase, FDTS, flavin dependent thymidylate synthase, flavin-dependent thymidylate synthase, flavin-dependent thymidylate synthase X, flavin-dependent TS, Thy1, thymidylate synthase 1, thymidylate synthase complementing protein, thymidylate synthase ThyX, thymidylate synthase X, ThyX, thyX-encoded thymidylate synthase, TSCP, TTHA1096

ECTree

     2 Transferases

         2.1 Transferring one-carbon groups

             2.1.1 Methyltransferases

                2.1.1.148 thymidylate synthase (FAD)

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Results	in table
14	Activating Compound
10362	AA Sequence
53	Application
1	CAS Registry Number
14	Cloned(Commentary)
123	Cofactor
16	Crystallization (Commentary)
1	Expression
2	General Information
8	IC50 Value
33	Inhibitors
10	Ki Value [mM]
17	KM Value [mM]
1	Metals/Ions
10	Molecular Weight [Da]
47	Natural Substrates/ Products (Substrates)
152	Organism
6	Pathway
137	PDB ID
1	pH Optimum
1	pH Range
1	Posttranslational Modification
44	Protein Variants
12	Purification (Commentary)
2	Reaction
5	Reaction Type
116	Reference
2	Storage Stability
123	Substrates and Products (Substrate)
20	Subunits
121	Synonyms
1	Systematic Name
1	Temperature Optimum [°C]
1	Temperature Range [°C]
7	Temperature Stability [°C]
7	Turnover Number [1/s]

Systematic Name

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Systematic Name on EC 2.1.1.148 - thymidylate synthase (FAD)

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SYSTEMATIC NAME

IUBMB Comments

5,10-methylenetetrahydrofolate,FADH2:dUMP C-methyltransferase

Contains FAD. All thymidylate synthases catalyse a reductive methylation involving the transfer of the methylene group of 5,10-methylenetetrahydrofolate to the C5 position of dUMP and a two electron reduction of the methylene group to a methyl group. Unlike the classical thymidylate synthase, ThyA (EC 2.1.1.45), which uses folate as both a 1-carbon donor and a source of reducing equivalents, this enzyme uses a flavin coenzyme as a source of reducing equivalents, which are derived from NADPH.