2.1.1.148: thymidylate synthase (FAD)

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For detailed information about thymidylate synthase (FAD), go to the full flat file.

Reaction

Synonyms

A674R, complementing thymidylate synthase, FDTS, flavin dependent thymidylate synthase, flavin-dependent thymidylate synthase, flavin-dependent thymidylate synthase X, flavin-dependent TS, Thy1, thymidylate synthase 1, thymidylate synthase complementing protein, thymidylate synthase ThyX, thymidylate synthase X, ThyX, thyX-encoded thymidylate synthase, TSCP, TTHA1096

ECTree

     2 Transferases

         2.1 Transferring one-carbon groups

             2.1.1 Methyltransferases

                2.1.1.148 thymidylate synthase (FAD)

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Results	in table
14	Activating Compound
10362	AA Sequence
53	Application
1	CAS Registry Number
14	Cloned(Commentary)
123	Cofactor
16	Crystallization (Commentary)
1	Expression
2	General Information
8	IC50 Value
33	Inhibitors
10	Ki Value [mM]
17	KM Value [mM]
1	Metals/Ions
10	Molecular Weight [Da]
47	Natural Substrates/ Products (Substrates)
152	Organism
6	Pathway
137	PDB ID
1	pH Optimum
1	pH Range
1	Posttranslational Modification
44	Protein Variants
12	Purification (Commentary)
2	Reaction
5	Reaction Type
116	Reference
2	Storage Stability
123	Substrates and Products (Substrate)
20	Subunits
121	Synonyms
1	Systematic Name
1	Temperature Optimum [°C]
1	Temperature Range [°C]
7	Temperature Stability [°C]
7	Turnover Number [1/s]

KI Value

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KI Value on EC 2.1.1.148 - thymidylate synthase (FAD)

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Ki VALUE [mM]

INHIBITOR

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

IMAGE

0.00013

(heptanoyl[[(4R)-2-phenyl-3-(phenylcarbonyl)-1,3-thiazolidin-4-yl]methyl] amino)acetic acid

Paramecium bursaria Chlorella virus 1

O41156

-

691285

0.000028

2-(furan-2-yl)-3-hydroxynaphthalene-1,4-dione

Helicobacter pylori

O26061

pH 8.0, 37°C

757894

0.000367

2-hydroxy-3-(4-methoxyphenyl)naphthalene-1,4-dione

Helicobacter pylori

O26061

pH 8.0, 37°C

757894

0.000258

2-hydroxy-3-propylnaphthalene-1,4-dione

Helicobacter pylori

O26061

pH 8.0, 37°C

757894

0.001

2-[4-fluoro-3-(trifluoromethyl)phenyl]-3-hydroxynaphthalene-1,4-dione

Helicobacter pylori

O26061

pH 8.0, 37°C

757894

0.0001

5-fluoro-2'-deoxyuridine 5'-monophosphate

Mycobacterium tuberculosis

-

inhibited both ThyA and ThyX

694812

0.000057

ethyl (4R)-2-phenyl-3-([(1-(3-2,2,2-trifluoroacetamido)propyl)-1H-1,2,3-triazol-4-yl]carbonyl)-1,3-thiazolidine-4-carboxylate

Paramecium bursaria Chlorella virus 1

O41156

-

691285

0.001

ethyl (4R)-2-phenyl-3-[[1-(2-thiophen-3-ylethyl)-1H-1,2,3-triazol-4-yl]carbonyl]-1,3-thiazolidine-4-carboxylate

Paramecium bursaria Chlorella virus 1

O41156

-

691285

0.002

ethyl (4R)-3-([1-[2-(4-fluorophenyl)ethyl]-1H-1,2,3-triazol-4-yl]carbonyl)-2-phenyl-1,3-thiazolidine-4-carboxylate

Paramecium bursaria Chlorella virus 1

O41156

-

691285

0.0035

ethyl (4R)-3-[[1-(7-hydroxyheptyl)-1H-1,2,3-triazol-4-yl]carbonyl]-2-phenyl-1,3-thiazolidine-4-carboxylate

Paramecium bursaria Chlorella virus 1

O41156

-

691285