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2.1.1.143: 24-methylenesterol C-methyltransferase

This is an abbreviated version!
For detailed information about 24-methylenesterol C-methyltransferase, go to the full flat file.

Word Map on EC 2.1.1.143

Reaction

S-adenosyl-L-methionine
+
24-methylenelophenol
=
S-adenosyl-L-homocysteine
+
(Z)-24-ethylidenelophenol

Synonyms

(S)-adenosyl-L-methionine-DELTA24-sterol methyltransferase, (S)-adenosyl-L-methionine:DELTA24(25)-sterol methyltransferase, 24-methylenelophenol C-241-methyltransferase, 24-sterol methyltransferase, C-24 SMT, C24-SMT2, DELTA24(25)-sterol methyltransferase, DELTA24-methyltransferase, DELTA24-sterol methyltransferase, methyltransferase, DELTA24-sterol, S-adenosylmethionine:DELTA24-sterol methyltransferase, SAM-DELTA24 sterol transmethylase, SMT1, SMT2, SMT2-1, sterol 24C-methyltransferase, sterol methyl transferase 2, sterol methyltransferase, sterol methyltransferase 2, zymosterol-24-methyltransferase

ECTree

     2 Transferases
         2.1 Transferring one-carbon groups
             2.1.1 Methyltransferases
                2.1.1.143 24-methylenesterol C-methyltransferase

Substrates Products

Substrates Products on EC 2.1.1.143 - 24-methylenesterol C-methyltransferase

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SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
S-adenosyl-L-methionine + 24(28)-methylene cycloartenol
S-adenosyl-L-homocysteine + 24(28)-ethylidene cycloartenol
show the reaction diagram
-
-
-
?
S-adenosyl-L-methionine + 24(28)-methylene lophenol
S-adenosyl-L-homocysteine + 24(28)-ethylidene lophenol
show the reaction diagram
S-adenosyl-L-methionine + 24-methylene-cholesta-5,7-dien-3beta-ol
S-adenosyl-L-homocysteine + cholesta-8,24-dien-3beta-ol
show the reaction diagram
S-adenosyl-L-methionine + 24-methylenelophenol
S-adenosyl-L-homocysteine + (Z)-24-ethylidenelophenol
show the reaction diagram
S-adenosyl-L-methionine + 24-methylenelophenol
S-adenosyl-L-homocysteine + 24-ethylidenelophenol
show the reaction diagram
S-adenosyl-L-methionine + 4alpha-methyl zymosterol
S-adenosyl-L-homocysteine + ?
show the reaction diagram
60% of the effectiveness of 24(28)-methylene lophenol
-
-
?
S-adenosyl-L-methionine + cycloartenol
S-adenosyl-L-homocysteine + 24-methylenecycloartanol
show the reaction diagram
S-adenosyl-L-methionine + cycloartenol
S-adenosyl-L-homocysteine + cyclolaudenol + 24(28)-methylene cycloartanol
show the reaction diagram
reaction of EC 2.1.1.142
-
-
?
S-adenosyl-L-methionine + ergosta-7,24(28)-dienol
S-adenosyl-L-homocysteine + ?
show the reaction diagram
equally effective as 24(28)-methylene lophenol
-
-
?
S-adenosyl-L-methionine + fecosterol
S-adenosyl-L-homocysteine + ?
show the reaction diagram
equally effective as 24(28)-methylene lophenol
-
-
?
S-adenosyl-L-methionine + lanosterol
S-adenosyl-L-homocysteine + 24beta-methyl lanosta-8,25(27)-enol + 24(28)-methylene lanosterol
show the reaction diagram
reaction of EC 2.1.1.142
-
-
?
S-adenosyl-L-methionine + lanosterol
S-adenosyl-L-homocysteine + ?
show the reaction diagram
-
12.4% of the activity with 24-methylenelophenol
-
?
S-adenosyl-L-methionine + obtusifoliol
S-adenosyl-L-homocysteine + ?
show the reaction diagram
S-adenosyl-L-methionine + zymosterol
S-adenosyl-L-homocysteine + ?
show the reaction diagram
70% of the effectiveness of 24(28)-methylene lophenol
-
-
?
S-adenosyl-L-methionine + zymosterol
S-adenosyl-L-homocysteine + fecosterol
show the reaction diagram
-
-
-
?
S-adenosyl-L-methionine + zymosterol
S-adenosyl-L-homocysteine + fecosterol + episterol + stigmasta-8,24-dienol + DELTA7-avenasterol
show the reaction diagram
-
5.2% of the activity with 24-methylenelophenol
-
?
additional information
?
-
enzyme catalyzes both the reactions of EC 2.1.1.142, cycloartenol 24-C-methyltransferase and EC 2.1.1.143, 24-methylenesterol C-methyltransferase. SMT1 catalyzes a sterol methylation pathway by the algal Delta25(27)-olefin route, where methylation proceeds by a conserved SN2 reaction and deprotonation proceeds from the pro-Z methyl group on lanosterol corresponding to C27
-
-
-