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2.1.1.142: cycloartenol 24-C-methyltransferase

This is an abbreviated version!
For detailed information about cycloartenol 24-C-methyltransferase, go to the full flat file.

Word Map on EC 2.1.1.142

Reaction

S-adenosyl-L-methionine
+
5alpha-cholesta-8,24-dien-3beta-ol
=
S-adenosyl-L-homocysteine
+
24-methylene-5alpha-cholest-8-en-3beta-ol

Synonyms

(S)-adenosyl-L-methionine-DELTA24-sterol methyltransferase, (S)-adenosyl-L-methionine:DELTA24(25)-sterol methyltransferase, 24-SMT, C-24-methyltransferase, C24-sterol methyltransferase type 1, DELTA24(25)-sterol methyltransferase, DELTA24-sterol methyltransferase, Erg6, GhSMT2-1, GhSMT2-2, More, SAM-DELTA24 sterol transmethylase, SAM:SMT, SMT, SMT protein, SMT-2, SMT-3, SMT1, SMT2, SMT2-1, sterol 24-C methyltransferase, sterol 24C-methyltransferases, sterol C-24 methyltransferase, sterol C-24-methyltransferase, sterol C-methyltransferase, sterol C24-methyltransferase, sterol methyl transferase, sterol methyltransferase, sterol methyltransferase2, zymosterol-24(25)-methyltransferase, zymosterol-24-methyltransferase

ECTree

     2 Transferases
         2.1 Transferring one-carbon groups
             2.1.1 Methyltransferases
                2.1.1.142 cycloartenol 24-C-methyltransferase

KI Value

KI Value on EC 2.1.1.142 - cycloartenol 24-C-methyltransferase

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Ki VALUE [mM]
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.000015
(24R)-24-methyl-25,26,27-trisnor-24-dimethylamino-N-oxide cycloartenol
-
-
0.00002
(24R)-24-methyl-25-azacycloartenol
-
-
0.000085
(24R,S)-24-Ethyl-25-azacycloartenol
-
-
0.00005
(24R,S)-24-Methyl-25,26,27-trisnor-24-dimethylsulfonium cycloartenol iodide
-
-
0.000025
(24R,S)-24-Methyl-25,26,27-trisnor-24-trimethylarsonium cycloartenol iodide
-
-
0.00002
(24R,S)-24-Methyl-25-azacycloartenol
-
-
0.000045
(24S)-24-methyl-25,26,27-trisnor-24-dimethylamino-N-oxide cycloartenol
-
-
0.00003
(24S)-24-methyl-25-azacycloartenol
-
-
0.000055
(3beta24R,S)-24-methyl-24-thionacycloart-3-ol iodide
-
-
0.00009
23-Azacholesterol
-
-
0.00009 - 0.25
24(28)-methylene cycloartanol
0.085
24(28)-methylenecycloartenol
-
-
0.171
24(28)-methylenencycloartanol
-
-
0.047
24,25-dehydro-27-methenyl-cycloartenol
-
pH 7.5, 35°C, recombinant enzyme
0.067
24,25-dehydro-27-methylene-cycloartenol
-
pH 7.5, 35°C, recombinant enzyme
0.00018
24-Azacholesterol
-
-
0.00003
24-Azacycloartanyl acetate
-
-
0.036
24-bromocycloartenol
0.042
24-dehydrocycloartenol
-
pH 7.5, 35°C, recombinant enzyme
0.032
24-fluorocycloartenol
0.000035
24-Methyl-25,26,27-trisnor-24-trimethylammonium cycloartenol iodide
-
-
0.025
24-methyl-9,19-cyclolanost-24-en-3-ol
-
-
0.00017
24-Oxo-25-azacycloartenol
-
-
0.002
24-thiacycloartanol
0.15
24beta-methylcycloartanol
-
pH 7.4, 35°C, substrate cycloartenol
0.000035
25,26,27-Trisnor-24-trimethylammonium cycloartenol iodide
-
-
0.000045
25-Azacholesterol
-
-
0.00001 - 0.00002
25-azacycloartanol
0.000002 - 0.0001
25-Azacycloartenol
0.00004
25-azacyloartenol
-
0.000014
25-azalanosterol
-
pH 7.5, 30°C, recombinant wild-type enzyme
0.042
26,27-dehydrocycloartenol
-
-
0.054
26,27-dehydrolanosterol
-
pH 7.5, 30°C, recombinant wild-type enzyme
0.049
26,27-dehydrozymosterol
-
pH 7.5, 35°C
0.093
26-difluorocycloartenol
0.071
26-fluorocycloartenol
0.047
26-methenylcycloartenol
-
rate of inactivation saturable, comparable to values obtained for cycloartenol
0.045 - 0.05
citrostadienol
0.017
cycloarta-24,26-dienol
-
-
0.03
Cycloartenol
-
natural substrate
0.025
cyclobranol
-
-
0.023
cyclolaudanol
-
-
0.007 - 0.009
cyclolaudenol
0.08
ergosterol
-
-
0.047 - 0.056
S-adenosyl-L-homocysteine
0.0001 - 0.207
sitosterol
additional information
additional information
-