2.1.1.140: (S)-coclaurine-N-methyltransferase
This is an abbreviated version!
For detailed information about (S)-coclaurine-N-methyltransferase, go to the full flat file.
Word Map on EC 2.1.1.140
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2.1.1.140
-
benzylisoquinoline
-
n-methylated
-
japonica
-
coptis
-
isoquinoline
-
norreticuline
-
s-reticuline
-
n-methyltransferases
-
norcoclaurine
-
poppy
-
scoulerine
-
somniferum
-
3\'-hydroxylase
-
4\'omt
-
magnoflorine
-
6-o-methyltransferase
-
opium
-
papaver
-
tetrahydroisoquinoline
-
aporphine
-
medicine
-
biotechnology
- 2.1.1.140
-
benzylisoquinoline
-
n-methylated
- japonica
- coptis
- isoquinoline
- norreticuline
-
s-reticuline
- n-methyltransferases
- norcoclaurine
- poppy
- scoulerine
- somniferum
-
3\'-hydroxylase
-
4\'omt
- magnoflorine
-
6-o-methyltransferase
-
opium
-
papaver
- tetrahydroisoquinoline
-
aporphine
- medicine
- biotechnology
Reaction
Synonyms
(S)-Coclaurine N-methyltransferase, 6OMT, CjCNMT, CMT, CNMT, CNMT protein, coclaurine N-methyltransferase, coclaurine-N-methyltransferase, FspC, S-adenosyl-L-methionine:coclaurine N-methyltransferase
ECTree
2.1.1.140 (S)-coclaurine-N-methyltransferaseAdvanced search results
results (
results (Substrates Products
Substrates Products on EC 2.1.1.140 - (S)-coclaurine-N-methyltransferase
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SUBSTRATE 
PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
(R)-coclaurine + S-adenosyl-L-methionine
S-adenosyl-L-homocysteine + (R)-N-methylcoclaurine
-
-
-
?
(R,S)-6-O-methylnorlaudanosoline + S-adenosyl-L-methionine
S-adenosyl-L-homocysteine + (R,S)-N-methyl-6-O-methyl-norlaudanosoline
-
-
-
?
(R,S)-norlaudanosoline + S-adenosyl-L-methionine
S-adenosyl-L-homocysteine + (R,S)-N-methylnorlaudanosoline
-
-
-
?
(R,S)-norreticuline + S-adenosyl-L-methionine
S-adenosyl-L-homocysteine + (R,S)-N-methylnorreticuline
-
-
-
?
(S)-coclaurine + S-adenosyl-L-methionine
S-adenosyl-L-homocysteine + (S)-N-methylcoclaurine
(S)-norcoclaurine + S-adenosyl-L-methionine
S-adenosyl-L-homocysteine + (R)-N-methylnorcoclaurine
-
strictly stereospecific, only (S)-norcoclaurine is N-methylated
-
?
1-methyl-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline + S-adenosyl-L-methionine
N-methyl-1-methyl-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline + S-adenosyl-L-methionine
-
-
-
?
6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline + S-adenosyl-L-methionine
N-methyl-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline + S-adenosyl-L-methionine
-
-
-
?
S-adenosyl-L-methionine + (R)-coclaurine
S-adenosyl-L-homocysteine + (R)-N-methylcoclaurine
S-adenosyl-L-methionine + (R)-N-methylcoclaurine
S-adenosyl-L-homocysteine + (R)-magnocurarine
-
-
-
?
S-adenosyl-L-methionine + (R,S)-6-O-methylnorlaudanosoline
S-adenosyl-L-homocysteine + (R,S)-6-O-methyllaudanosoline
-
-
-
?
S-adenosyl-L-methionine + (R,S)-6-O-methylnorlaudanosoline
S-adenosyl-L-homocysteine + (R,S)-N-methyl-6-O-methylnorlaudanosoline
S-adenosyl-L-methionine + (R,S)-norlaudanosoline
S-adenosyl-L-homocysteine + (R,S)-N-methylnorlaudanosoline
S-adenosyl-L-methionine + (R,S)-norreticuline
S-adenosyl-L-homocysteine + (R,S)-N-methylnorreticuline
-
55% of the activity with (S)-coclaurine
-
-
?
S-adenosyl-L-methionine + (RS)-coclaurine
S-adenosyl-L-homocysteine + (RS)-N-methylcoclaurine
-
-
-
?
S-adenosyl-L-methionine + (S)-coclaurine
S-adenosyl-L-homocysteine + (S)-N-methylcoclaurine
S-adenosyl-L-methionine + (S)-N-methylcoclaurine
S-adenosyl-L-homocysteine + ?
weak activity
-
-
?
S-adenosyl-L-methionine + (S)-reticuline
S-adenosyl-L-homocysteine + (S)-tembetarine
-
-
-
?
S-adenosyl-L-methionine + 1-methyl-6,7-dihydroxy-1,2,3,4-tetrahydroisoquinoline
S-adenosyl-L-homocysteine + 6,7-dihydroxy-1,N-dimethyl-1,2,3,4-tetrahydroisoquinoline
S-adenosyl-L-methionine + 6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline
S-adenosyl-L-homocysteine + 6,7-dimethoxy-N-methyl-1,2,3,4-tetrahydroisoquinoline
-
39% of the activity with (S)-coclaurine
-
-
?
S-adenosyl-L-methionine + 6,7-dimethoxy-N-methyl-1,2,3,4-tetrahydroisoquinoline
S-adenosyl-L-homocysteine + 6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline
-
180% of the activity with (R,S)-norreticuline
-
-
?
S-adenosyl-L-methionine + heliamine
S-adenosyl-L-homocysteine + N-methylheliamine
-
-
-
?
(S)-coclaurine + S-adenosyl-L-methionine
S-adenosyl-L-homocysteine + (S)-N-methylcoclaurine
-
-
-
?
(S)-coclaurine + S-adenosyl-L-methionine
S-adenosyl-L-homocysteine + (S)-N-methylcoclaurine
Berberis koetineana
-
-
-
?
(S)-coclaurine + S-adenosyl-L-methionine
S-adenosyl-L-homocysteine + (S)-N-methylcoclaurine
-
-
-
?
(S)-coclaurine + S-adenosyl-L-methionine
S-adenosyl-L-homocysteine + (S)-N-methylcoclaurine
Bocconia cordata
-
-
-
?
(S)-coclaurine + S-adenosyl-L-methionine
S-adenosyl-L-homocysteine + (S)-N-methylcoclaurine
-
-
-
?
(S)-coclaurine + S-adenosyl-L-methionine
S-adenosyl-L-homocysteine + (S)-N-methylcoclaurine
-
-
-
?
(S)-coclaurine + S-adenosyl-L-methionine
S-adenosyl-L-homocysteine + (S)-N-methylcoclaurine
Corydalis vaginans
-
-
-
?
(S)-coclaurine + S-adenosyl-L-methionine
S-adenosyl-L-homocysteine + (S)-N-methylcoclaurine
-
-
-
?
(S)-coclaurine + S-adenosyl-L-methionine
S-adenosyl-L-homocysteine + (S)-N-methylcoclaurine
-
-
-
?
(S)-coclaurine + S-adenosyl-L-methionine
S-adenosyl-L-homocysteine + (S)-N-methylcoclaurine
-
-
-
?
(S)-coclaurine + S-adenosyl-L-methionine
S-adenosyl-L-homocysteine + (S)-N-methylcoclaurine
-
-
-
?
(S)-coclaurine + S-adenosyl-L-methionine
S-adenosyl-L-homocysteine + (S)-N-methylcoclaurine
-
-
-
?
(S)-coclaurine + S-adenosyl-L-methionine
S-adenosyl-L-homocysteine + (S)-N-methylcoclaurine
-
-
-
?
(S)-coclaurine + S-adenosyl-L-methionine
S-adenosyl-L-homocysteine + (S)-N-methylcoclaurine
Thalictrum glaucum
-
-
-
?
(S)-coclaurine + S-adenosyl-L-methionine
S-adenosyl-L-homocysteine + (S)-N-methylcoclaurine
-
-
-
?
(S)-coclaurine + S-adenosyl-L-methionine
S-adenosyl-L-homocysteine + (S)-N-methylcoclaurine
-
strictly stereospecific, only (S)-coclaurine is N-methylated
-
?
(S)-coclaurine + S-adenosyl-L-methionine
S-adenosyl-L-homocysteine + (S)-N-methylcoclaurine
Tinospora fragosa
-
-
-
?
S-adenosyl-L-methionine + (R)-coclaurine
S-adenosyl-L-homocysteine + (R)-N-methylcoclaurine
-
122% of the activity with (S)-coclaurine
-
-
?
S-adenosyl-L-methionine + (R)-coclaurine
S-adenosyl-L-homocysteine + (R)-N-methylcoclaurine
-
240% of the activity with (R,S)-norreticuline
-
-
?
S-adenosyl-L-methionine + (R)-coclaurine
S-adenosyl-L-homocysteine + (R)-N-methylcoclaurine
-
-
-
?
S-adenosyl-L-methionine + (R,S)-6-O-methylnorlaudanosoline
S-adenosyl-L-homocysteine + (R,S)-N-methyl-6-O-methylnorlaudanosoline
-
38% of the activity with (S)-coclaurine
-
-
?
S-adenosyl-L-methionine + (R,S)-6-O-methylnorlaudanosoline
S-adenosyl-L-homocysteine + (R,S)-N-methyl-6-O-methylnorlaudanosoline
-
69% of the activity with (R,S)-norreticuline
-
-
?
S-adenosyl-L-methionine + (R,S)-norlaudanosoline
S-adenosyl-L-homocysteine + (R,S)-N-methylnorlaudanosoline
-
48% of the activity with (S)-coclaurine
-
-
?
S-adenosyl-L-methionine + (R,S)-norlaudanosoline
S-adenosyl-L-homocysteine + (R,S)-N-methylnorlaudanosoline
-
49% of the activity with (R,S)-norreticuline
-
-
?
S-Adenosyl-L-methionine + (S)-coclaurine
?
-
pathway for the biosynthesis of the benzyltetrahydroisoquinoline alkaloid reticuline: (S)-norcoclaurine is stereoselectively metabolized to (S)-reticuline via (S)-coclaurine, (S)-N-methylcoclaurine and (S)-3'-hydroxy-N-methylcoclaurine
-
-
?
S-Adenosyl-L-methionine + (S)-coclaurine
?
-
pathway for the biosynthesis of the benzyltetrahydroisoquinoline alkaloid reticuline: (S)-norcoclaurine is stereoselectively metabolized to (S)-reticuline via (S)-coclaurine, (S)-N-methylcoclaurine and (S)-3'-hydroxy-N-methylcoclaurine
-
-
?
S-Adenosyl-L-methionine + (S)-coclaurine
?
-
pathway for the biosynthesis of the benzyltetrahydroisoquinoline alkaloid reticuline: (S)-norcoclaurine is stereoselectively metabolized to (S)-reticuline via (S)-coclaurine, (S)-N-methylcoclaurine and (S)-3'-hydroxy-N-methylcoclaurine
-
-
?
S-adenosyl-L-methionine + (S)-coclaurine
S-adenosyl-L-homocysteine + (S)-N-methylcoclaurine
-
-
-
?
S-adenosyl-L-methionine + (S)-coclaurine
S-adenosyl-L-homocysteine + (S)-N-methylcoclaurine
-
isoquinoline alkaloid biosynthesis
-
-
?
S-adenosyl-L-methionine + (S)-coclaurine
S-adenosyl-L-homocysteine + (S)-N-methylcoclaurine
-
sequential bi-substrate mechanism, ordered bi bi or rapid equilibrium random bi bi
-
-
?
S-adenosyl-L-methionine + (S)-coclaurine
S-adenosyl-L-homocysteine + (S)-N-methylcoclaurine
-
sequential mechanism, 153% of the activity with (R,S)-norreticuline
-
-
?
S-adenosyl-L-methionine + (S)-coclaurine
S-adenosyl-L-homocysteine + (S)-N-methylcoclaurine
-
isoquinoline alkaloid biosynthesis
-
-
?
S-adenosyl-L-methionine + (S)-coclaurine
S-adenosyl-L-homocysteine + (S)-N-methylcoclaurine
-
expression systems tested by analyzing recombinant CMT protein
-
-
?
S-adenosyl-L-methionine + (S)-coclaurine
S-adenosyl-L-homocysteine + (S)-N-methylcoclaurine
-
-
-
-
?
S-adenosyl-L-methionine + (S)-coclaurine
S-adenosyl-L-homocysteine + (S)-N-methylcoclaurine
-
-
-
?
S-adenosyl-L-methionine + (S)-coclaurine
S-adenosyl-L-homocysteine + (S)-N-methylcoclaurine
analysis of the evolutionary recruitment of enzymes into plant alkaloid pathways
-
-
?
S-Adenosyl-L-methionine + (S)-coclaurine
S-Adenosyl-L-homocysteine + N-methylcoclaurine
-
-
-
?
S-Adenosyl-L-methionine + (S)-coclaurine
S-Adenosyl-L-homocysteine + N-methylcoclaurine
-
-
-
?
S-Adenosyl-L-methionine + (S)-coclaurine
S-Adenosyl-L-homocysteine + N-methylcoclaurine
-
-
-
?
S-adenosyl-L-methionine + 1-methyl-6,7-dihydroxy-1,2,3,4-tetrahydroisoquinoline
S-adenosyl-L-homocysteine + 6,7-dihydroxy-1,N-dimethyl-1,2,3,4-tetrahydroisoquinoline
-
10% of the activity with (S)-coclaurine
-
-
?
S-adenosyl-L-methionine + 1-methyl-6,7-dihydroxy-1,2,3,4-tetrahydroisoquinoline
S-adenosyl-L-homocysteine + 6,7-dihydroxy-1,N-dimethyl-1,2,3,4-tetrahydroisoquinoline
-
15% of the activity with (R,S)-norreticuline
-
-
?
additional information
?
-
-
no activity with (R,S)-scoulerine, 1,2,3,4-tetrahydroisoquinoline, 1,2,3,4-tetrahydro-3-isoquinolinecarboxylic acid or (+)-emetine
-
-
?
additional information
?
-
-
no activity with: (R,S)-scoulerine, 1,2,3,4-tetrahydroisoquinoline and 1,2,3,4-tetrahydro-3-isoquinoline carboxylic acid (+)-emetine
-
-
?
additional information
?
-
-
involvement in magnoflorine biosynthesis determined, crude enzyme preparation of recombinant CNMT protein analyzed, recombinant CjCNMT protein shown to convert (S)-corytuberine to magnoflorine
-
-
?
