2.1.1.13: methionine synthase

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For detailed information about methionine synthase, go to the full flat file.

Reaction

Synonyms

5-methyltetrahydrofolate homocysteine methyltransferase, 5-methyltetrahydrofolate-homocysteine methyltransferase, 5-methyltetrahydrofolate-homocysteine S-methyltransferase, 5-methyltetrahydrofolate-homocysteine transmethylase, B12 N5-methyltetrahydrofolate homocysteine methyltransferase, B12-dependent methionine synthase, cobalamin-dependent methionine synthase, folate-dependent methionine synthase, Met6p, MetH, methionine synthase, methionine synthetase, methyltetrahydrofolate-homocysteine vitamin B12 methyltransferase, methyltransferase, methyltetrahydrofolate-homocysteine, MetS, MS, MS1, MTR, N-methyltetrahydrofolate:L-homocysteine methyltransferase, N5-methyltetrahydrofolate methyltransferase, N5-methyltetrahydrofolate-homocysteine cobalamin methyltransferase, N5-methyltetrahydrofolic-homocysteine vitamin B12 transmethylase, tetrahydrofolate methyltransferase, tetrahydropteroylglutamate methyltransferase, tetrahydropteroylglutamic methyltransferase, vitamin B12 methyltransferase

ECTree

     2 Transferases

         2.1 Transferring one-carbon groups

             2.1.1 Methyltransferases

                2.1.1.13 methionine synthase

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Results	in table
20	Activating Compound
32678	AA Sequence
10	Application
1	CAS Registry Number
10	Cloned(Commentary)
99	Cofactor
10	Crystallization (Commentary)
27596	Disease/ Diagnostics
3	Expression
3	General Information
10	General Stability
20	IC50 Value
20	Inhibitors
2	Ki Value [mM]
25	KM Value [mM]
6	Localization
10	Metals/Ions
21	Molecular Weight [Da]
5	Natural Substrates/ Products (Substrates)
1342	Organism
13	Pathway
32	PDB ID
7	pH Optimum
3	pH Range
3	pH Stability
23	Protein Variants
30	Purification (Commentary)
28	Reaction
1	Reaction Type
111	Reference
1	Renatured (Commentary)
70	Source Tissue
40	Specific Activity [micromol/min/mg]
8	Storage Stability
83	Substrates and Products (Substrate)
9	Subunits
40	Synonyms
1	Systematic Name
4	Temperature Optimum [°C]
2	Temperature Range [°C]
3	Temperature Stability [°C]
4	Turnover Number [1/s]

Systematic Name

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Systematic Name on EC 2.1.1.13 - methionine synthase

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SYSTEMATIC NAME

IUBMB Comments

5-methyltetrahydrofolate:L-homocysteine S-methyltransferase

Contains zinc and cobamide. The enzyme becomes inactivated occasionally during its cycle by oxidation of Co(I) to Co(II). Reactivation by reductive methylation is catalysed by the enzyme itself, with S-adenosyl-L-methionine as the methyl donor and a reducing system. For the mammalian enzyme, the reducing system involves NADPH and EC 1.16.1.8, [methionine synthase] reductase. In bacteria, the reducing agent is flavodoxin, and no further catalyst is needed (the flavodoxin is kept in the reduced state by NADPH and EC 1.18.1.2, ferredoxin---NADP+ reductase). Acts on the monoglutamate as well as the triglutamate folate, in contrast with EC 2.1.1.14, 5-methyltetrahydropteroyltriglutamate---homocysteine S-methyltransferase, which acts only on the triglutamate.