Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
5-methyl-5,6,7,8-tetrahydropteroylheptaglutamate + homocysteine
?
-
-
-
-
?
5-methyl-5,6,7,8-tetrahydropteroylpentaglutamate + L-homocysteine
?
5-methyl-5,6,7,8-tetrahydropteroyltriglutamate + L-homocysteine
?
-
-
-
-
?
5-methyltetrahydrofolate + 2-mercaptoethanol
S-methylmercaptoethanol + tetrahydrofolate
-
-
-
?
5-methyltetrahydrofolate + L-homocysteine
tetrahydrofolate + L-methionine
N5-methyltetrahydrofolate + L-homocysteine
tetrahydrofolate + L-methionine
N5-methyltetrahydropteroylheptaglutamate + L-homocysteine
tetrahydropteroylheptaglutamate + L-methionine
-
-
-
-
?
N5-methyltetrahydropteroylmonoglutamate + L-homocysteine
tetrahydropteroylmonoglutamate + L-methionine
N5-methyltetrahydropteroylpentaglutamate + L-homocysteine
tetrahydropteroylpentaglutamate + L-methionine
N5-methyltetrahydropteroyltriglutamate + L-homocysteine
tetrahydropteroyltriglutamate + L-methionine
S-adenosyl-L-methionine + L-homocysteine
methionine + S-adenosyl-L-homocysteine
-
-
-
?
S-adenosyl-L-methionine + L-selenohomocysteine
selenomethionine + S-adenosyl-L-homocysteine
-
-
-
?
S-adenosyl-L-methionine + tetrahydrofolate
5-methyltetrahydrofolate + S-adenosyl-L-homocysteine
-
-
-
?
additional information
?
-
5-methyl-5,6,7,8-tetrahydropteroylpentaglutamate + L-homocysteine
?
-
-
-
-
?
5-methyl-5,6,7,8-tetrahydropteroylpentaglutamate + L-homocysteine
?
-
-
-
-
?
5-methyltetrahydrofolate + L-homocysteine
tetrahydrofolate + L-methionine
-
-
-
-
?
5-methyltetrahydrofolate + L-homocysteine
tetrahydrofolate + L-methionine
-
-
-
-
?
5-methyltetrahydrofolate + L-homocysteine
tetrahydrofolate + L-methionine
-
homocysteine increases methionine synthase mRNA level
-
-
?
5-methyltetrahydrofolate + L-homocysteine
tetrahydrofolate + L-methionine
-
-
-
-
?
5-methyltetrahydrofolate + L-homocysteine
tetrahydrofolate + L-methionine
-
gene expression is induced by light, but more strongly induced under salt, drought and cold stresses and by treatment with ABA or H2O2
-
-
?
5-methyltetrahydrofolate + L-homocysteine
tetrahydrofolate + L-methionine
-
methionine biosynthesis
-
-
?
N5-methyltetrahydrofolate + L-homocysteine
tetrahydrofolate + L-methionine
-
transcription is not regulated by Met, but is enhanced by homocysteine and repressed by choline and betaine. Synthesis of the enzyme is also regulated posttranscriptionally
-
-
?
N5-methyltetrahydrofolate + L-homocysteine
tetrahydrofolate + L-methionine
-
-
-
?
N5-methyltetrahydrofolate + L-homocysteine
tetrahydrofolate + L-methionine
-
-
-
-
?
N5-methyltetrahydrofolate + L-homocysteine
tetrahydrofolate + L-methionine
-
-
-
-
?
N5-methyltetrahydrofolate + L-homocysteine
tetrahydrofolate + L-methionine
-
-
-
-
?
N5-methyltetrahydrofolate + L-homocysteine
tetrahydrofolate + L-methionine
-
-
-
-
?
N5-methyltetrahydrofolate + L-homocysteine
tetrahydrofolate + L-methionine
-
-
-
-
?
N5-methyltetrahydropteroylmonoglutamate + L-homocysteine
tetrahydropteroylmonoglutamate + L-methionine
-
-
-
-
?
N5-methyltetrahydropteroylmonoglutamate + L-homocysteine
tetrahydropteroylmonoglutamate + L-methionine
-
-
-
-
?
N5-methyltetrahydropteroylmonoglutamate + L-homocysteine
tetrahydropteroylmonoglutamate + L-methionine
-
-
-
-
?
N5-methyltetrahydropteroylmonoglutamate + L-homocysteine
tetrahydropteroylmonoglutamate + L-methionine
-
-
-
-
?
N5-methyltetrahydropteroylmonoglutamate + L-homocysteine
tetrahydropteroylmonoglutamate + L-methionine
-
-
-
-
?
N5-methyltetrahydropteroylmonoglutamate + L-homocysteine
tetrahydropteroylmonoglutamate + L-methionine
-
-
-
?
N5-methyltetrahydropteroylmonoglutamate + L-homocysteine
tetrahydropteroylmonoglutamate + L-methionine
-
-
-
-
?
N5-methyltetrahydropteroylmonoglutamate + L-homocysteine
tetrahydropteroylmonoglutamate + L-methionine
-
-
-
-
?
N5-methyltetrahydropteroylmonoglutamate + L-homocysteine
tetrahydropteroylmonoglutamate + L-methionine
-
-
-
-
?
N5-methyltetrahydropteroylmonoglutamate + L-homocysteine
tetrahydropteroylmonoglutamate + L-methionine
-
-
-
-
?
N5-methyltetrahydropteroylmonoglutamate + L-homocysteine
tetrahydropteroylmonoglutamate + L-methionine
-
-
-
-
?
N5-methyltetrahydropteroylmonoglutamate + L-homocysteine
tetrahydropteroylmonoglutamate + L-methionine
Ochromonas malhamensis
-
-
-
-
?
N5-methyltetrahydropteroylmonoglutamate + L-homocysteine
tetrahydropteroylmonoglutamate + L-methionine
-
-
-
-
?
N5-methyltetrahydropteroylmonoglutamate + L-homocysteine
tetrahydropteroylmonoglutamate + L-methionine
-
-
-
-
?
N5-methyltetrahydropteroylmonoglutamate + L-homocysteine
tetrahydropteroylmonoglutamate + L-methionine
-
-
-
-
?
N5-methyltetrahydropteroylmonoglutamate + L-homocysteine
tetrahydropteroylmonoglutamate + L-methionine
-
-
-
-
?
N5-methyltetrahydropteroylmonoglutamate + L-homocysteine
tetrahydropteroylmonoglutamate + L-methionine
-
-
-
?
N5-methyltetrahydropteroylmonoglutamate + L-homocysteine
tetrahydropteroylmonoglutamate + L-methionine
-
-
-
-
?
N5-methyltetrahydropteroylmonoglutamate + L-homocysteine
tetrahydropteroylmonoglutamate + L-methionine
-
-
-
-
?
N5-methyltetrahydropteroylpentaglutamate + L-homocysteine
tetrahydropteroylpentaglutamate + L-methionine
-
-
-
-
?
N5-methyltetrahydropteroylpentaglutamate + L-homocysteine
tetrahydropteroylpentaglutamate + L-methionine
-
-
-
-
?
N5-methyltetrahydropteroyltriglutamate + L-homocysteine
tetrahydropteroyltriglutamate + L-methionine
-
-
-
-
?
N5-methyltetrahydropteroyltriglutamate + L-homocysteine
tetrahydropteroyltriglutamate + L-methionine
-
-
-
-
?
N5-methyltetrahydropteroyltriglutamate + L-homocysteine
tetrahydropteroyltriglutamate + L-methionine
-
-
-
-
?
N5-methyltetrahydropteroyltriglutamate + L-homocysteine
tetrahydropteroyltriglutamate + L-methionine
-
-
-
-
?
N5-methyltetrahydropteroyltriglutamate + L-homocysteine
tetrahydropteroyltriglutamate + L-methionine
-
-
-
-
?
N5-methyltetrahydropteroyltriglutamate + L-homocysteine
tetrahydropteroyltriglutamate + L-methionine
-
-
-
-
?
N5-methyltetrahydropteroyltriglutamate + L-homocysteine
tetrahydropteroyltriglutamate + L-methionine
-
-
-
-
?
N5-methyltetrahydropteroyltriglutamate + L-homocysteine
tetrahydropteroyltriglutamate + L-methionine
-
-
-
-
?
N5-methyltetrahydropteroyltriglutamate + L-homocysteine
tetrahydropteroyltriglutamate + L-methionine
Ochromonas malhamensis
-
-
-
-
?
N5-methyltetrahydropteroyltriglutamate + L-homocysteine
tetrahydropteroyltriglutamate + L-methionine
-
-
-
-
?
N5-methyltetrahydropteroyltriglutamate + L-homocysteine
tetrahydropteroyltriglutamate + L-methionine
-
-
-
-
?
N5-methyltetrahydropteroyltriglutamate + L-homocysteine
tetrahydropteroyltriglutamate + L-methionine
-
-
-
-
?
N5-methyltetrahydropteroyltriglutamate + L-homocysteine
tetrahydropteroyltriglutamate + L-methionine
-
-
-
?
N5-methyltetrahydropteroyltriglutamate + L-homocysteine
tetrahydropteroyltriglutamate + L-methionine
-
-
-
-
?
additional information
?
-
-
binding of the folate substrate
-
-
?
additional information
?
-
-
S-adenosylhomocysteine replaces homocysteine as methyl acceptor to a limited extent
-
-
?
additional information
?
-
the activation barrier for the reductive elimination reaction (24.4 kcal per mol) is almost four times higher than that for the SN2 reaction (7.3 kcal per mol). This energy demand is rooted in the structural distortion of the corrin ring that is induced en route to the formation of the triangular transition state. The reductive elimination reaction demands the syn accommodation of the methyl group and the substrate over the upper face of the corrin ring, which also accounts for the high energy demand of the reaction. Therefore the reductive elimination pathway for MetH-catalyzed methyl transfer cannot be considered as one of the possible mechanistic routes
-
-
?
additional information
?
-
-
S-adenosylhomocysteine replaces homocysteine as methyl acceptor to a limited extent
-
-
?
additional information
?
-
-
binding of the folate substrate
-
-
?