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2.1.1.13: methionine synthase

This is an abbreviated version!
For detailed information about methionine synthase, go to the full flat file.

Word Map on EC 2.1.1.13

Reaction

5-methyltetrahydrofolate
+
L-homocysteine
=
tetrahydrofolate
+
L-methionine

Synonyms

5-methyltetrahydrofolate homocysteine methyltransferase, 5-methyltetrahydrofolate-homocysteine methyltransferase, 5-methyltetrahydrofolate-homocysteine S-methyltransferase, 5-methyltetrahydrofolate-homocysteine transmethylase, B12 N5-methyltetrahydrofolate homocysteine methyltransferase, B12-dependent methionine synthase, cobalamin-dependent methionine synthase, folate-dependent methionine synthase, Met6p, MetH, methionine synthase, methionine synthetase, methyltetrahydrofolate-homocysteine vitamin B12 methyltransferase, methyltransferase, methyltetrahydrofolate-homocysteine, MetS, MS, MS1, MTR, N-methyltetrahydrofolate:L-homocysteine methyltransferase, N5-methyltetrahydrofolate methyltransferase, N5-methyltetrahydrofolate-homocysteine cobalamin methyltransferase, N5-methyltetrahydrofolic-homocysteine vitamin B12 transmethylase, tetrahydrofolate methyltransferase, tetrahydropteroylglutamate methyltransferase, tetrahydropteroylglutamic methyltransferase, vitamin B12 methyltransferase

ECTree

     2 Transferases
         2.1 Transferring one-carbon groups
             2.1.1 Methyltransferases
                2.1.1.13 methionine synthase

Inhibitors

Inhibitors on EC 2.1.1.13 - methionine synthase

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INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
1-methyl-5-amino-benzimidazole
-
IC50: more than 0.15 mM
1-methyl-5-nitro-7-methoxybenzimidazole
-
IC50: 0.15 mM
1-methyl-5-nitro-benzimidazole
-
IC50: more than 0.15 mM
1-methylbenzimidazole
-
IC50: more than 0.15 mM
2,1,3-benzothiadiazole
-
IC50: more than 0.15 mM
2-nitro-1H-benzimidazole
-
IC50: 0.12 mM
4-(7-nitroquinoxalin-2-yl)benzoic acid
mixed inhibition type
4-amino-2,1,3-benzothiadiazole
-
IC50: more than 0.15 mM
4-nitro-2,1,3-benzothiadiazole
-
IC50: 0.08 mM
4-nitro-N-[2-(5-nitro-1H-benzimidazol-2-yl)ethyl]benzamide
competitive inhibition
5-amino-7-methoxy-N1-methylbenzimidazole
-
IC50: 0.095 mM
5-amino-7-methoxybenzimidazole
-
IC50: more than 0.15 mM
5-aminobenzimidazole
-
IC50: more than 0.15 mM
5-methoxybenzimidazole
-
IC50: more than 0.15 mM
5-nitro-7-methoxybenzimidazole
-
IC50: 0.1 mM
benzimidazole
-
IC50: more than 0.15 mM
N-(3-bromo-4-[[(1-[2-[(2,2-dimethylpropanoyl)amino]-4-methyl-6-oxo-1,6-dihydropyrimidin-5-yl]aziridin-2-yl)methyl](methyl)amino]benzoyl)-L-glutamic acid
-
-
N-[(5-nitro-1H-benzimidazol-2-yl)methyl]benzamide
mixed inhibition type
ZL-031
-
i.e. diethyl N-[4-[(2-[2,4-diamino-5-(2,3-dibromopropane)-5,6,7,8-tetrahydropyrido(3,2-d)pyrimidin-6-yl]methyl)amino]3-bromo-benzoyl]L-glutamate
ZL-033
-
i.e. N-[4-[(2-[2,4-diamino-5-(2,3-dibromopropane)-5,6,7,8-tetrahydropyrido(3,2-d)pyrimidin-6-yl]methyl)amino]3-bromo-benzoyl]L-glutamic acid