2.1.1.13: methionine synthase

This is an abbreviated version!
For detailed information about methionine synthase, go to the full flat file.

Reaction

Synonyms

5-methyltetrahydrofolate homocysteine methyltransferase, 5-methyltetrahydrofolate-homocysteine methyltransferase, 5-methyltetrahydrofolate-homocysteine S-methyltransferase, 5-methyltetrahydrofolate-homocysteine transmethylase, B12 N5-methyltetrahydrofolate homocysteine methyltransferase, B12-dependent methionine synthase, cobalamin-dependent methionine synthase, folate-dependent methionine synthase, Met6p, MetH, methionine synthase, methionine synthetase, methyltetrahydrofolate-homocysteine vitamin B12 methyltransferase, methyltransferase, methyltetrahydrofolate-homocysteine, MetS, MS, MS1, MTR, N-methyltetrahydrofolate:L-homocysteine methyltransferase, N5-methyltetrahydrofolate methyltransferase, N5-methyltetrahydrofolate-homocysteine cobalamin methyltransferase, N5-methyltetrahydrofolic-homocysteine vitamin B12 transmethylase, tetrahydrofolate methyltransferase, tetrahydropteroylglutamate methyltransferase, tetrahydropteroylglutamic methyltransferase, vitamin B12 methyltransferase

ECTree

     2 Transferases

         2.1 Transferring one-carbon groups

             2.1.1 Methyltransferases

                2.1.1.13 methionine synthase

Advanced search results

Do not include text mining results

Include results (more...)

Include results (more...)

Results	in table
20	Activating Compound
32678	AA Sequence
10	Application
1	CAS Registry Number
10	Cloned(Commentary)
99	Cofactor
10	Crystallization (Commentary)
27596	Disease/ Diagnostics
3	Expression
3	General Information
10	General Stability
20	IC50 Value
20	Inhibitors
2	Ki Value [mM]
25	KM Value [mM]
6	Localization
10	Metals/Ions
21	Molecular Weight [Da]
5	Natural Substrates/ Products (Substrates)
1342	Organism
13	Pathway
32	PDB ID
7	pH Optimum
3	pH Range
3	pH Stability
23	Protein Variants
30	Purification (Commentary)
28	Reaction
1	Reaction Type
111	Reference
1	Renatured (Commentary)
70	Source Tissue
40	Specific Activity [micromol/min/mg]
8	Storage Stability
83	Substrates and Products (Substrate)
9	Subunits
40	Synonyms
1	Systematic Name
4	Temperature Optimum [°C]
2	Temperature Range [°C]
3	Temperature Stability [°C]
4	Turnover Number [1/s]

IC50 Value

print visible entries

print all entries

Go back to the abbreviated version
of the Enzyme Summary Page.

IC50 Value on EC 2.1.1.13 - methionine synthase

Please wait a moment until all data is loaded. This message will disappear when all data is loaded.

top print hide show all columns Go to IC50 Value Search

Please wait a moment until the data is sorted. This message will disappear when the data is sorted.

IC50 VALUE [mM]

INHIBITOR

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

IMAGE

0.15

1-methyl-5-amino-benzimidazole

Rattus norvegicus

-

IC50: more than 0.15 mM

673596

0.15

1-methyl-5-nitro-7-methoxybenzimidazole

Rattus norvegicus

-

IC50: 0.15 mM

673596

0.15

1-methyl-5-nitro-benzimidazole

Rattus norvegicus

-

IC50: more than 0.15 mM

673596

0.15

1-methylbenzimidazole

Rattus norvegicus

-

IC50: more than 0.15 mM

673596

0.15

2,1,3-benzothiadiazole

Rattus norvegicus

-

IC50: more than 0.15 mM

673596

0.12

2-nitro-1H-benzimidazole

Rattus norvegicus

-

IC50: 0.12 mM

673596

0.009

4-(7-nitroquinoxalin-2-yl)benzoic acid

Rattus norvegicus

Q9Z2Q4

pH 7.4, 37°C

733507

0.15

4-amino-2,1,3-benzothiadiazole

Rattus norvegicus

-

IC50: more than 0.15 mM

673596

0.08

4-nitro-2,1,3-benzothiadiazole

Rattus norvegicus

-

IC50: 0.08 mM

673596

0.018

4-nitro-N-[2-(5-nitro-1H-benzimidazol-2-yl)ethyl]benzamide

Rattus norvegicus

Q9Z2Q4

pH 7.4, 37°C

733507

0.095

5-amino-7-methoxy-N1-methylbenzimidazole

Rattus norvegicus

-

IC50: 0.095 mM

673596

0.15

5-amino-7-methoxybenzimidazole

Rattus norvegicus

-

IC50: more than 0.15 mM

673596

0.15

5-aminobenzimidazole

Rattus norvegicus

-

IC50: more than 0.15 mM

673596

0.15

5-methoxybenzimidazole

Rattus norvegicus

-

IC50: more than 0.15 mM

673596

0.1

5-nitro-7-methoxybenzimidazole

Rattus norvegicus

-

IC50: 0.1 mM

673596

0.15

benzimidazole

Rattus norvegicus

-

IC50: more than 0.15 mM

673596

0.00415

N-(3-bromo-4-[[(1-[2-[(2,2-dimethylpropanoyl)amino]-4-methyl-6-oxo-1,6-dihydropyrimidin-5-yl]aziridin-2-yl)methyl](methyl)amino]benzoyl)-L-glutamic acid

Homo sapiens

-

pH 7.2, 37°C

733653

0.02

N-[(5-nitro-1H-benzimidazol-2-yl)methyl]benzamide

Rattus norvegicus

Q9Z2Q4

pH 7.4, 37°C

733507

0.01

ZL-031

Homo sapiens

-

at 37°C

684467

0.0014

ZL-033

Homo sapiens

-

at 37°C

684467