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2.1.1.125: histone-arginine N-methyltransferase

This is an abbreviated version!
For detailed information about histone-arginine N-methyltransferase, go to the full flat file.

Word Map on EC 2.1.1.125

deleted, now covered by EC 2.1.1.319, type I protein arginine methyltransferase, EC 2.1.1.320, type II protein arginine methyltransferase, EC 2.1.1.321, type III protein arginine methyltransferase and EC 2.1.1.322, type IV protein arginine methyltransferase


ECTree

     2 Transferases
         2.1 Transferring one-carbon groups
             2.1.1 Methyltransferases
                2.1.1.125 histone-arginine N-methyltransferase

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Resultsin table
98AA Sequence
5Expression
30General Information
38kcat/KM [mM/s]
102PDB ID

Expression

Expression on EC 2.1.1.125 - histone-arginine N-methyltransferase

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EXPRESSION
ORGANISM
UNIPROT
LITERATURE
construction of PRMT1 and CARM1 single and double knockouts in siRNA-treated HeLa cells, the mutations affect the expression of diverse other genes, expression analysis and phenotypes, overview
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in vivo PRMT5 overexpression is caused by the altered expression of the PRMT5-specific microRNAs 19a, 25, 32, 92, 92b, and 96 and results in the increased global symmetric methylation of H3R8 and H4R3
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overall PRMT2 expression is upregulated in breast cancer tissues
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PRMT1 expression is upregulated in the intestine during metamorphosis
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through its interaction with the estrogen receptoralpha, peroxisome proliferator-activated receptor, progesterone receptor, and the retinoic acid receptor, PRMT2 shows a ligand-dependent increase in transcriptional activity
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