2.1.1.116: 3'-hydroxy-N-methyl-(S)-coclaurine 4'-O-methyltransferase

This is an abbreviated version!
For detailed information about 3'-hydroxy-N-methyl-(S)-coclaurine 4'-O-methyltransferase, go to the full flat file.

Reaction

Synonyms

(R,S)-3'-hydroxy-N-methylcoclaurine 4'-O-methyltransferase, (S)-3'-hydroxy-N-methylcoclaurine 4'-O-methyltransferase, (S)-3'-hydroxy-N-methylcoclaurine 4-O-methyltransferase, (S)-3'-hydroxy-N-methylcoclaurine-4'-O-methyltransferase, 3'-hydroxy N-methylcoclaurine 4'-O-methyltransferase, 3'-hydroxy-(S)-N-methylcoclaurine-4'-O-methyltransferase, 3'-hydroxy-N-methylcoclaurine 4'-O-methyltransferase, 3-hydroxy-N-methylcoclaurine 4-O-methyltransferase, 4'-OMT, 4'OMT, HOMT, Methyltransferase, (S)-3'-hydroxy-N-methylcoclaurine 4'-, Ps4'OMT, S-Adenosyl-L-methionine: 3'-hydroxy-N-methyl-(S)-coclaurine-4'-O-methyl transferase, S-adenosyl-L-methionine:(R,S)-3'-hydroxy-N-methylcoclaurine 4'-O-methyltransferase, S-adenosyl-L-methionine:3'-hydroxy-N-methylcoclaurine 4'-O-methyltransferase, SAM:3'-hydroxy-N-methyl-(S)-coclaurine-4'-O-methyltransferase

ECTree

     2 Transferases

         2.1 Transferring one-carbon groups

             2.1.1 Methyltransferases

                2.1.1.116 3'-hydroxy-N-methyl-(S)-coclaurine 4'-O-methyltransferase

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Results	in table
6	Activating Compound
10	AA Sequence
3	Application
1	CAS Registry Number
7	Cloned(Commentary)
2	General Information
7	Inhibitors
8	KM Value [mM]
2	Localization
6	Molecular Weight [Da]
11	Natural Substrates/ Products (Substrates)
16	Organism
6	Pathway
5	pH Optimum
1	pH Range
5	Purification (Commentary)
1	Reaction
7	Reaction Type
16	Reference
16	Source Tissue
1	Specific Activity [micromol/min/mg]
1	Storage Stability
21	Substrates and Products (Substrate)
2	Subunits
29	Synonyms
1	Systematic Name
6	Temperature Optimum [°C]
2	Temperature Stability [°C]

Natural Substrates Products

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Natural Substrates Products on EC 2.1.1.116 - 3'-hydroxy-N-methyl-(S)-coclaurine 4'-O-methyltransferase

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NATURAL SUBSTRATE

NATURAL PRODUCT

REACTION DIAGRAM

ORGANISM

UNIPROT

COMMENTARY
(Substrate)

LITERATURE
(Substrate)

COMMENTARY
(Product)

LITERATURE
(Product)

REVERSIBILITY
r=reversible
ir=irreversible
?=not specified

S-adenosyl-L-homocysteine + (S)-reticuline

S-adenosyl-L-methionine + 3'-hydroxy-N-methyl-(S)-coclaurine

2 entries

S-Adenosyl-L-methionine + 3'-hydroxy-N-methyl-(S)-coclaurine

?

Berberis koetineana

-

the enzyme catalyzes the last step in (S)-reticuline biosynthesis

15191

-

-

?

S-Adenosyl-L-methionine + 3'-hydroxy-N-methyl-(S)-coclaurine

S-Adenosyl-L-homocysteine + (S)-reticuline

5 entries

additional information

?

-

Papaver somniferum

-

the enzyme is central to the biosynthesis of tetrahydroisoquinoline-derived alkaloids

657166

-

-

?

S-adenosyl-L-homocysteine + (S)-reticuline

S-adenosyl-L-methionine + 3'-hydroxy-N-methyl-(S)-coclaurine

Coptis japonica

Q9LEL5

-

676471

-

-

?

S-adenosyl-L-homocysteine + (S)-reticuline

S-adenosyl-L-methionine + 3'-hydroxy-N-methyl-(S)-coclaurine

Eschscholzia californica

-

-

676471, 685739

-

-

?

S-Adenosyl-L-methionine + 3'-hydroxy-N-methyl-(S)-coclaurine

S-Adenosyl-L-homocysteine + (S)-reticuline

Coptis chinensis

B6RJT5

-

733598

-

-

?

S-Adenosyl-L-methionine + 3'-hydroxy-N-methyl-(S)-coclaurine

S-Adenosyl-L-homocysteine + (S)-reticuline

Coptis japonica

-

-

689501

-

-

?

S-Adenosyl-L-methionine + 3'-hydroxy-N-methyl-(S)-coclaurine

S-Adenosyl-L-homocysteine + (S)-reticuline

Coptis japonica

Q9LEL5

-

676471

-

-

?

S-Adenosyl-L-methionine + 3'-hydroxy-N-methyl-(S)-coclaurine

S-Adenosyl-L-homocysteine + (S)-reticuline

Eschscholzia californica

-

-

687887

-

-

?

S-Adenosyl-L-methionine + 3'-hydroxy-N-methyl-(S)-coclaurine

S-Adenosyl-L-homocysteine + (S)-reticuline

Papaver somniferum

-

-

689454, 735093

-

-

?