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2.1.1.113: site-specific DNA-methyltransferase (cytosine-N4-specific)

This is an abbreviated version!
For detailed information about site-specific DNA-methyltransferase (cytosine-N4-specific), go to the full flat file.

Word Map on EC 2.1.1.113

Reaction

S-adenosyl-L-methionine
+
DNA cytosine
=
S-adenosyl-L-homocysteine
+
DNA N4-methylcytosine

Synonyms

BamHI [cytosine-N4] MTase, cytosine-N5-methyltransferase, DNA-(N4-cytosine)-methyltransferase, DNA[cytosine-N4]methyltransferase, DraR1, HP_1368, M.AatII, M.AvaI, M.BalI, M.BcnIA, M.BcnIB, M.BglII, M.BsoBI, M.BstNI, M.CbeI, M.CsyAIP, M.CsyBIP, M.EsaBC1I, M.EsaBC2I, M.EsaLHCI, M.Hpy99ORF244P, M.Hpy99ORF248P, M.Hpy99ORF629P, M.HpyAIIP, M.HpyAXIIBP, M.MjaIP, M.MjaV, M.MthZI, M.MwoI, M.NcoI, M.NgoMXV, M.Pac25I, M.PhiGIP, M.PhiHII, M.PhoIIIP, M.PspGI, M.PvuII, M.RsaI, M.SapIA, M.SapIB, M.ScaI, M.SfiI, M.SmaI, M.StyCIP, M.XcyI, M.XmaI, M.XveII protein, M2.MboII, M2.NcuI, m4C-forming Mtase, m4C-MTase, modification methylase, More, N4-cytosine methyltransferase, N4-cytosine MTase, N4-methyltransferase, N4mC MTase, ORF16000P, restriction-modification system, sll0729, SuaI

ECTree

     2 Transferases
         2.1 Transferring one-carbon groups
             2.1.1 Methyltransferases
                2.1.1.113 site-specific DNA-methyltransferase (cytosine-N4-specific)

Reference

Reference on EC 2.1.1.113 - site-specific DNA-methyltransferase (cytosine-N4-specific)

Please use the Reference Search for a specific query.
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REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Klimasauskas, S.; Timinskas, A.; Menkevicius, S.; Butkiene, D.; Butkus, V.; Janulaitis, A.
Sequence motifs characteristic of DNA[cytosine-N4]methyltransferases: similarity to adenine and cytosine-C5 DNA-methylases
Nucleic Acids Res.
17
9823-9832
1989
Citrobacter freundii, Kocuria varians, Citrobacter freundii RFL9, Kocuria varians RFL19
Manually annotated by BRENDA team
Roberts, R.J.; Macelis, D.
Restriction enzymes and their isoschizomers
Nucleic Acids Res.
20
2167-2180
1992
Bacteria
Manually annotated by BRENDA team
Malygin, E.G.; Zinoviev, V.V.; Evdokimov, A.A.; Lindstrom, W.M., Jr.; Reich, N.O.; Hattman, S.
DNA-(cytosine-N4)- and (adenine-N6)-methyltransferases have different kinetic mechanisms but the same reaction route: a comparison of M.BamHI and T4 Dam
J. Biol. Chem.
20
1-31
2003
Bacillus amyloliquefaciens
-
Manually annotated by BRENDA team
O'Gara, M.; Adams, G.M.; Gong, W.; Kobayashi, R.; Blumenthal, R.M.; Cheng, X.
Expression, purification, mass spectrometry, crystallization and multiwavelength anomalous diffraction of selenomethionyl PvuII DNA methyltransferase (cytosine-N4-specific)
Eur. J. Biochem.
247
1009-1018
1997
Proteus vulgaris
Manually annotated by BRENDA team
Zinoviev, V.V.; Evdokimov, A.A.; Malygin, E.G.
DNA-(N4-Cytosine)-methyltransferase from Bacillus amyloliquefaciens: mechanism of action derived from steady-state kinetics
Mol. Biol. (Mosk.)
37
116-124
2003
Bacillus amyloliquefaciens
-
Manually annotated by BRENDA team
Lindstrom, W.M., Jr.; Malygin, E.G.; Ovechkina, L.G.; Zinoviev, V.V.; Reich, N.O.
Functional analysis of BamHI DNA cytosine-N4 methyltransferase
J. Mol. Biol.
325
711-720
2003
Bacillus amyloliquefaciens
Manually annotated by BRENDA team
Adams, G.M.; Blumenthal, R.M.
The PvuII DNA (cytosine-N4)-methyltransferase comprises two trypsin-defined domains, each of which binds a molecule of S-adenosyl-L-methionine
Biochemistry
36
8284-8292
1997
Proteus vulgaris
Manually annotated by BRENDA team
Bujnicki, J.M.; Radlinska, M.
Molecular evolution of DNA-(cytosine-N4) methyltransferases: evidence for their polyphyletic origin
Nucleic Acids Res.
27
4501-4509
1999
Cenarchaeum symbiosum, Cenarchaeum symbiosum (O74074), Helicobacter pylori, Helicobacter pylori (Q9ZLF1), Lactobacillus phage phig1e, Methanocaldococcus jannaschii, Pseudomonas alcaligenes, Pyrococcus horikoshii, Salmonella enterica subsp. enterica serovar Typhi, Xanthomonas citri pv. malvacearum, Streptomyces fimbriatus (O52513), Streptomyces caespitosus (O52692), Saccharopolyspora sp. (O52711), Methanothermobacter wolfeii (O59647), Bacillus subtilis (O68556), Bacillus subtilis (Q45489), Gordonia rubripertincta (O85488), Pyrococcus sp. (O93645), Trichormus variabilis (P0A462), Proteus hauseri (P11409), Serratia marcescens (P14230), Citrobacter freundii (P14243), Citrobacter freundii (Q04845), Kocuria varians (P14244), Bacillus amyloliquefaciens (P18051), Bacillus amyloliquefaciens (P23941), Methanothermobacter thermautotrophicus (P29568), Xanthomonas campestris pv. cyanopsidis (P30774), Geobacillus stearothermophilus (P70986), Curtobacterium albidum (P71101), Halobacterium phage phiH (Q38204), Neisseria gonorrhoeae (Q9AKV2), Methanothermobacter thermautotrophicus Z-250 (P29568), Neisseria gonorrhoeae ME11 (Q9AKV2), Citrobacter freundii RFL9 (P14243), Bacillus amyloliquefaciens H (P23941), Citrobacter freundii 4111 (Q04845), Geobacillus stearothermophilus JN2091 (P70986), Kocuria varians RFL19 (P14244), Cenarchaeum symbiosum B (O74074), Cenarchaeum symbiosum A, Pseudomonas alcaligenes NCIB 986, Salmonella enterica subsp. enterica serovar Typhi CT18, Pyrococcus horikoshii OT-3
Manually annotated by BRENDA team
Gong, W.; O'Gara, M.; Blumenthal, R.M.; Cheng, X.
Structure of pvu II DNA-(cytosine N4) methyltransferase, an example of domain permutation and protein fold assignment
Nucleic Acids Res.
25
2702-2715
1997
Proteus vulgaris
Manually annotated by BRENDA team
Merkiene, E.; Vilkaitis, G.; Klimasauskas, S.
A pair of single-strand and double-strand DNA cytosine-N4 methyltransferases from Bacillus centrosporus
Biol. Chem.
379
569-571
1998
Brevibacillus centrosporus
Manually annotated by BRENDA team
Jeltsch, A.
The cytosine N4-methyltransferase M.PvuII also modifies adenine residues
Biol. Chem.
382
707-710
2001
Proteus vulgaris
Manually annotated by BRENDA team
Malygin, E.G.; Ovechkina, L.G.; Zinoviev, V.V.; Lindstrem, U.M.; Reich, N.O.
DNA-(N4-cytosine)-methyltransferase from Bacillus amyloliquefaciens: kinetic and substrate-binding properties
Mol. Biol. (Mosk.)
35
35-44
2001
Bacillus amyloliquefaciens
-
Manually annotated by BRENDA team
Zinoviev, V.V.; Yakishchik, S.I.; Evdokimov, A.A.; Malygin, E.G.; Hattman, S.
Symmetry elements in DNA structure important for recognition/methylation by DNA [amino]-methyltransferases
Nucleic Acids Res.
32
3930-3934
2004
Bacillus amyloliquefaciens
Manually annotated by BRENDA team
Yu, Y.J.; Yang, M.T.
A novel restriction-modification system from Xanthomonas campestris pv. vesicatoria encodes a m4C-methyltransferase and a nonfunctional restriction endonuclease
FEMS Microbiol. Lett.
272
83-90
2007
Xanthomonas campestris (Q3BWM2)
Manually annotated by BRENDA team
Carpenter, M.A.; Bhagwat, A.S.
DNA base flipping by both members of the PspGI restriction-modification system
Nucleic Acids Res.
36
5417-5425
2008
Pyrococcus sp. GI-H
Manually annotated by BRENDA team
Furmanek-Blaszk, B.; Boratynski, R.; Zolcinska, N.; Sektas, M.
M1.Mboll and M2.Mboll type IIS methyltransferases: different specificities, the same target
Microbiology
155
1111-1121
2009
Moraxella bovis, Moraxella cuniculi
Manually annotated by BRENDA team
Aranda, J.; Roca, M.; Lopez-Canut, V.; Tunon, I.
Theoretical study of the catalytic mechanism of DNA-(N4-cytosine)-methyltransferase from the bacterium Proteus vulgaris
J. Phys. Chem. B
114
8467-8473
2010
Proteus vulgaris
Manually annotated by BRENDA team
Clark, T.A.; Murray, I.A.; Morgan, R.D.; Kislyuk, A.O.; Spittle, K.E.; Boitano, M.; Fomenkov, A.; Roberts, R.J.; Korlach, J.
Characterization of DNA methyltransferase specificities using single-molecule, real-time DNA sequencing
Nucleic Acids Res.
40
e29
2012
Acetobacter aceti, Geobacillus stearothermophilus, uncultured bacterium, Cereibacter sphaeroides
Manually annotated by BRENDA team
Grogan, D.W.
Cytosine methylation by the SuaI restriction-modification system: implications for genetic fidelity in a hyperthermophilic archaeon
J. Bacteriol.
185
4657-4661
2003
Sulfolobus acidocaldarius, Sulfolobus acidocaldarius DG185
Manually annotated by BRENDA team
Aranda, J.; Roca, M.; Tunon, I.
Substrate promiscuity in DNA methyltransferase M.PvuII. A mechanistic insight
Org. Biomol. Chem.
10
5395-5400
2012
Proteus vulgaris
Manually annotated by BRENDA team
Furuta, Y.; Namba-Fukuyo, H.; Shibata, T.F.; Nishiyama, T.; Shigenobu, S.; Suzuki, Y.; Sugano, S.; Hasebe, M.; Kobayashi, I.
Methylome diversification through changes in DNA methyltransferase sequence specificity
PLoS Genet.
10
e1004272
2014
Helicobacter pylori
Manually annotated by BRENDA team
Chung, D.; Farkas, J.; Huddleston, J.R.; Olivar, E.; Westpheling, J.
Methylation by a unique alpha-class N4-cytosine methyltransferase is required for DNA transformation of Caldicellulosiruptor bescii DSM6725
PLoS ONE
7
e43844
2012
Caldicellulosiruptor bescii (B9MK94), Caldicellulosiruptor bescii, Caldicellulosiruptor bescii DSM 6725 (B9MK94)
Manually annotated by BRENDA team
Gaertner, K.; Klaehn, S.; Watanabe, S.; Mikkat, S.; Scholz, I.; Hess, W.R.; Hagemann, M.
Cytosine N4-methylation via M.Ssp6803II is involved in the regulation of transcription, fine-tuning of DNA replication and DNA repair in the cyanobacterium Synechocystis sp. PCC 6803
Front. Microbiol.
10
1233
2019
Synechocystis sp. PCC 6803 (P74637)
Manually annotated by BRENDA team
Li, S.; Cai, J.; Lu, H.; Mao, S.; Dai, S.; Hu, J.; Wang, L.; Hua, X.; Xu, H.; Tian, B.; Zhao, Y.; Hua, Y.
N4-Cytosine DNA methylation is involved in the maintenance of genomic stability in Deinococcus radiodurans
Front. Microbiol.
10
1905
2019
Deinococcus radiodurans, Deinococcus radiodurans R1
Manually annotated by BRENDA team
Kumar, S.; Karmakar, B.C.; Nagarajan, D.; Mukhopadhyay, A.K.; Morgan, R.D.; Rao, D.N.
N4-cytosine DNA methylation regulates transcription and pathogenesis in Helicobacter pylori
Nucleic Acids Res.
46
3429-3445
2018
Helicobacter pylori (O25921), Helicobacter pylori 26695 (O25921)
Manually annotated by BRENDA team