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2.1.1.103: phosphoethanolamine N-methyltransferase

This is an abbreviated version!
For detailed information about phosphoethanolamine N-methyltransferase, go to the full flat file.

Word Map on EC 2.1.1.103

Reaction

S-adenosyl-L-methionine
+
Ethanolamine phosphate
=
S-adenosyl-L-homocysteine
+
N-methylethanolamine phosphate

Synonyms

AtNMT1, DPR2, More, NMT1, NMT2, PEAMT, PEAMT1, Pfpmt, phosphodimethylethanolamine methyltransferase, phosphoethanolamine methyltransferase, phosphoethanolamine N-methyltransferase, phosphoethanolamine-N-methyltransferases, phosphomethylethanolamine N-methyltransferase, PMEAMT, PMT, PMT-1, PMT1, PMT2, PVX_083045, S-adenosyl-L-methionine:phosphoethanolamine N-methyltransferase, SoPEAMT

ECTree

     2 Transferases
         2.1 Transferring one-carbon groups
             2.1.1 Methyltransferases
                2.1.1.103 phosphoethanolamine N-methyltransferase

Reference

Reference on EC 2.1.1.103 - phosphoethanolamine N-methyltransferase

Please use the Reference Search for a specific query.
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REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Datko, A.H.; Mudd, H.S.
Enzymes of phosphatidylcholine synthesis in lemna, soybean, and carrot
Plant Physiol.
88
1338-1348
1988
Daucus carota, Glycine max, Lemna aequinoctialis
Manually annotated by BRENDA team
Andriamampandry, C.; Massarelli, R.; Freysz, L.; Kanfer, J.N.
A rat brain cytosolic N-methyltransferase(s) activity converting phosphorylethanolamine into phosphorylcholine
Biochem. Biophys. Res. Commun.
171
758-763
1990
Rattus norvegicus, Rattus norvegicus Sprague-Dawley
Manually annotated by BRENDA team
Andriamampandry, C.; Massarelli, R.; Kanfer, J.N.
Properties of a partially purified phosphodimethylethanolamine methyltransferase from rat brain cytosol
Biochem. J.
288
267-272
1992
Rattus norvegicus, Rattus norvegicus Sprague-Dawley
Manually annotated by BRENDA team
Weretilnyk, E.A.; Smith, D.D.; Wilch, G.A.; Summers, P.S.
Enzymes of choline synthesis in spinach. Response of phospho-base N-methyltransferase activities to light and salinity
Plant Physiol.
109
1085-1091
1995
Spinacia oleracea
Manually annotated by BRENDA team
Nuccio, M.L.; Ziemak, M.J.; Henry, S.A.; Weretilnyk, E.A.; Hanson, A.D.
cDNA cloning of phosphoethanolamine N-methyltransferase from spinach by complementation in Schizosaccharomyces pombe and characterization of the recombinant enzyme
J. Biol. Chem.
275
14095-14101
2000
Spinacia oleracea (Q9M571), Spinacia oleracea
Manually annotated by BRENDA team
Bolognese, C.P.; McGraw, P.
The isolation and characterization in yeast of a gene for Arabidopsis S-adenosylmethionine:phospho-ethanolamine N-methyltransferase
Plant Physiol.
124
1800-1813
2000
Arabidopsis thaliana (Q9FR44)
Manually annotated by BRENDA team
Lorenzin, D.; Webb, C.; Summers, P.S.; Weretilnyk, E.A.
Enzymes of choline synthesis in diverse plants: Variation in phospho-base N-methyltransferase activities
Can. J. Bot.
79
897-904
2001
Amaranthus caudatus, Beta vulgaris, Glycine max, Gossypium hirsutum, Limonium perezii, Pisum sativum, Spinacia oleracea
Manually annotated by BRENDA team
McNeil, S.D.; Nuccio, M.L.; Ziemak, M.J.; Hanson, A.D.
Enhanced synthesis of choline and glycine betaine in transgenic tobacco plants that overexpress phosphoethanolamine N-methyltransferase
Proc. Natl. Acad. Sci. USA
98
10001-10005
2001
Nicotiana tabacum
Manually annotated by BRENDA team
Mou, Z.; Wang, X.; Fu, Z.; Dai, Y.; Han, C.; Ouyang, J.; Bao, F.; Hu, Y.; Li, J.
Silencing of phosphoethanolamine N-methyltransferase results in temperature-sensitive male sterility and salt hypersensitivity in Arabidopsis
Plant Cell
14
2031-2043
2002
Arabidopsis thaliana (Q9FR44)
Manually annotated by BRENDA team
Charron, J.B.F.; Breton, G.; Danyluk, J.; Muzac, I.; Ibrahim, R.K.; Sarhan, F.
Molecular and biochemical characterization of a cold-regulated phosphoethanolamine N-methyltransferase from wheat
Plant Physiol.
129
363-373
2002
Triticum aestivum (Q8VYX1), Triticum aestivum
Manually annotated by BRENDA team
Smith, D.D.; Summers, P.S.; Weretilnyk, E.A.
Phosphocholine synthesis in spinach: characterization of phosphoethanolamine N-methyltransferase
Physiol. Plant.
108
286-294
2000
Spinacia oleracea
-
Manually annotated by BRENDA team
Pessi, G.; Choi, J.Y.; Reynolds, J.M.; Voelker, D.R.; Mamoun, C.B.
In vivo evidence for the specificity of Plasmodium falciparum phosphoethanolamine methyltransferase and its coupling to the Kennedy pathway
J. Biol. Chem.
280
12461-12466
2005
Plasmodium falciparum, Plasmodium falciparum (Q6T755)
Manually annotated by BRENDA team
Cruz-Ramirez, A.; Lopez-Bucio, J.; Ramirez-Pimentel, G.; Zurita-Silva, A.; Sanchez-Calderon, L.; Ramirez-Chavez, E.; Gonzalez-Ortega, E.; Herrera-Estrella, L.
The xipotl mutant of Arabidopsis reveals a critical role for phospholipid metabolism in root system development and epidermal cell integrity
Plant Cell
16
2020-2034
2004
Arabidopsis thaliana
Manually annotated by BRENDA team
Tabuchi, T.; Kawaguchi, Y.; Azuma, T.; Nanmori, T.; Yasuda, T.
Similar regulation patterns of choline monooxygenase, phosphoethanolamine N-methyltransferase and S-adenosyl-L-methionine synthetase in leaves of the halophyte Atriplex nummularia L
Plant Cell Physiol.
46
505-513
2005
Atriplex nummularia
Manually annotated by BRENDA team
Pessi, G.; Kociubinski, G.; Mamoun, C.B.
A pathway for phosphatidylcholine biosynthesis in Plasmodium falciparum involving phosphoethanolamine methylation
Proc. Natl. Acad. Sci. USA
101
6206-6211
2004
Plasmodium falciparum (Q6T755), Plasmodium falciparum
Manually annotated by BRENDA team
Brendza, K.M.; Haakenson, W.; Cahoon, R.E.; Hicks, L.M.; Palavalli, L.H.; Chiapelli, B.J.; McLaird, M.; McCarter, J.P.; Williams, D.J.; Hresko, M.C.; Jez, J.M.
Phosphoethanolamine N-methyltransferase (PMT-1) catalyzes the first reaction of a new pathway for phosphocholine biosynthesis in Caenorhabditis elegans
Biochem. J.
404
439-448
2007
Caenorhabditis elegans
Manually annotated by BRENDA team
Tabuchi, T.; Okada, T.; Azuma, T.; Nanmori, T.; Yasuda, T.
Posttranscriptional regulation by the upstream open reading frame of the phosphoethanolamine N-methyltransferase gene
Biosci. Biotechnol. Biochem.
70
2330-2334
2006
Arabidopsis sp., Spinacia oleracea (Q9M571)
Manually annotated by BRENDA team
Witola, W.H.; Pessi, G.; El Bissati, K.; Reynolds, J.M.; Mamoun, C.B.
Localization of the phosphoethanolamine methyltransferase of the human malaria parasite Plasmodium falciparum to the Golgi apparatus
J. Biol. Chem.
281
21305-21311
2006
Plasmodium falciparum
Manually annotated by BRENDA team
Witola, W.H.; Ben Mamoun, C.
Choline induces transcriptional repression and proteasomal degradation of the malarial phosphoethanolamine methyltransferase
Eukaryot. Cell
6
1618-1624
2007
Plasmodium falciparum
Manually annotated by BRENDA team
Witola, W.H.; El Bissati, K.; Pessi, G.; Xie, C.; Roepe, P.D.; Ben Mamoun, C.
Disruption of the Plasmodium falciparum PfPMT gene results in a complete loss of phosphatidylcholine biosynthesis via the SDPM pathway and severe growth and survival defects
J. Biol. Chem.
283
27636-27643
2008
Plasmodium falciparum
Manually annotated by BRENDA team
Reynolds, J.M.; Takebe, S.; Choi, J.Y.; El Bissati, K.; Witola, W.H.; Bobenchik, A.M.; Hoch, J.C.; Voelker, D.R.; Mamoun, C.B.
Biochemical and genetic analysis of the phosphoethanolamine methyltransferase of the human malaria parasite Plasmodium falciparum
J. Biol. Chem.
283
7894-7900
2008
Plasmodium falciparum (Q6T755), Plasmodium falciparum
Manually annotated by BRENDA team
Wu, S.; Yu, Z.; Wang, F.; Li, W.; Ye, C.; Li, J.; Tang, J.; Ding, J.; Zhao, J.; Wang, B.
Cloning, characterization, and transformation of the phosphoethanolamine N-methyltransferase gene (ZmPEAMT1) in maize (Zea mays L.)
Mol. Biotechnol.
36
102-112
2007
Zea mays (Q5SDQ0), Zea mays
Manually annotated by BRENDA team
Bezsonova, I.; Rujan, I.; Bobenchik, A.M.; Gorbatyuk, V.; Maciejewski, M.W.; Gorbatyuk, O.; Hao, B.; Arthanari, H.; Mamoun, C.B.; Hoch, J.C.
1H, 13C, and 15N chemical shift assignments for PfPMT, a phosphoethanolamine methyltransferase from Plasmodium falciparum
Biomol. NMR Assign.
7
17-20
2013
Plasmodium falciparum
Manually annotated by BRENDA team
Bobenchik, A.M.; Choi, J.Y.; Mishra, A.; Rujan, I.N.; Hao, B.; Voelker, D.R.; Hoch, J.C.; Mamoun, C.B.
Identification of inhibitors of Plasmodium falciparum phosphoethanolamine methyltransferase using an enzyme-coupled transmethylation assay
BMC Biochem.
11
4-4
2010
Plasmodium falciparum
Manually annotated by BRENDA team
BeGora, M.D.; Macleod, M.J.; McCarry, B.E.; Summers, P.S.; Weretilnyk, E.A.
Identification of phosphomethylethanolamine N-methyltransferase from Arabidopsis and its role in choline and phospholipid metabolism
J. Biol. Chem.
285
29147-29155
2010
Arabidopsis thaliana, Arabidopsis thaliana (Q944H0)
Manually annotated by BRENDA team
Lee, S.G.; Haakenson, W.; McCarter, J.P.; Williams, D.J.; Hresko, M.C.; Jez, J.M.
Thermodynamic evaluation of ligand binding in the plant-like phosphoethanolamine methyltransferases of the parasitic nematode Haemonchus contortus
J. Biol. Chem.
286
38060-38068
2011
Haemonchus contortus
Manually annotated by BRENDA team
Lee, S.G.; Kim, Y.; Alpert, T.D.; Nagata, A.; Jez, J.M.
Structure and reaction mechanism of phosphoethanolamine methyltransferase from the malaria parasite Plasmodium falciparum: an antiparasitic drug target
J. Biol. Chem.
287
1426-1434
2012
Plasmodium falciparum (Q6T755), Plasmodium falciparum
Manually annotated by BRENDA team
Lee, S.G.; Alpert, T.D.; Jez, J.M.
Crystal structure of phosphoethanolamine methyltransferase from Plasmodium falciparum in complex with amodiaquine
Bioorg. Med. Chem. Lett.
22
4990-4993
2012
Plasmodium falciparum (Q6T755), Plasmodium falciparum
Manually annotated by BRENDA team
Yuan, Y.; Qi, L.; Yu, J.; Wang, X.; Huang, L.
Transcriptome-wide analysis of SAMe superfamily to novelty phosphoethanolamine N-methyltransferase copy in Lonicera japonica
Int. J. Mol. Sci.
16
521-534
2015
Lonicera japonica
Manually annotated by BRENDA team
Saen-Oon, S.; Lee, S.G.; Jez, J.M.; Guallar, V.
An alternative mechanism for the methylation of phosphoethanolamine catalyzed by Plasmodium falciparum phosphoethanolamine methyltransferase
J. Biol. Chem.
289
33815-33825
2014
Plasmodium falciparum (Q6T755), Plasmodium falciparum
Manually annotated by BRENDA team
Bobenchik, A.M.; Witola, W.H.; Augagneur, Y.; Nic Lochlainn, L.; Garg, A.; Pachikara, N.; Choi, J.Y.; Zhao, Y.O.; Usmani-Brown, S.; Lee, A.; Adjalley, S.H.; Samanta, S.; Fidock, D.A.; Voelker, D.R.; Fikrig, E.; Ben Mamoun, C.
Plasmodium falciparum phosphoethanolamine methyltransferase is essential for malaria transmission
Proc. Natl. Acad. Sci. USA
110
18262-18267
2013
Plasmodium falciparum (Q8IDQ9), Plasmodium falciparum
Manually annotated by BRENDA team
Garg, A.; Lukk, T.; Kumar, V.; Choi, J.Y.; Augagneur, Y.; Voelker, D.R.; Nair, S.; Ben Mamoun, C.
Structure, function and inhibition of the phosphoethanolamine methyltransferases of the human malaria parasites Plasmodium vivax and Plasmodium knowlesi
Sci. Rep.
5
9064
2015
Plasmodium knowlesi (B3L8G9), Plasmodium knowlesi, Plasmodium vivax (A5K867), Plasmodium vivax
Manually annotated by BRENDA team
Li, Q.; Xie, J.; Ma, X.; Li, D.
Molecular cloning of phosphoethanolamine N-methyltransferase (PEAMT) gene and its promoter from the halophyte Suaeda liaotungensis and their response to salt stress
Acta Physiol. Plant.
38
39
2016
Suaeda liaotungensis (A0N067)
-
Manually annotated by BRENDA team
Hirashima, T.; Toyoshima, M.; Moriyama, T.; Nakamura, Y.; Sato, N.
Characterization of phosphoethanolamine-N-methyltransferases in green algae
Biochem. Biophys. Res. Commun.
488
141-146
2017
Chlamydomonas asymmetrica (A0A125SQH6), Chlamydomonas applanata (A0A1W7HP20), Chlamydomonas asymmetrica NIES-2207 (A0A125SQH6), Chlamydomonas applanata NIES-2202 (A0A1W7HP20)
Manually annotated by BRENDA team
Singh, J.; Mansuri, R.; Vijay, S.; Sahoo, G.C.; Sharma, A.; Kumar, M.
Docking predictions based Plasmodium falciparum phosphoethanolamine methyl transferase inhibitor identification and in-vitro antimalarial activity analysis
BMC Chem.
13
43
2019
Plasmodium falciparum (Q6T755), Plasmodium falciparum
Manually annotated by BRENDA team
Lee, S.G.; Jez, J.M.
Conformational changes in the di-domain structure of Arabidopsis phosphoethanolamine methyltransferase leads to active-site formation
J. Biol. Chem.
292
21690-21702
2017
Arabidopsis thaliana (Q944H0), Arabidopsis thaliana (Q9C6B9), Arabidopsis thaliana (Q9FR44)
Manually annotated by BRENDA team
Zou, Y.; Zhang, X.; Tan, Y.; Huang, J.B.; Zheng, Z.; Tao, L.Z.
Phosphoethanolamine N-methyltransferase 1 contributes to maintenance of root apical meristem by affecting ROS and auxin-regulated cell differentiation in Arabidopsis
New Phytol.
224
258-273
2019
Arabidopsis thaliana (Q9FR44)
Manually annotated by BRENDA team
Chen, W.; Taylor, M.C.; Barrow, R.A.; Croyal, M.; Masle, J.
Loss of phosphoethanolamine N-methyltransferases abolishes phosphatidylcholine synthesis and is lethal
Plant Physiol.
179
124-142
2019
Arabidopsis thaliana (Q944H0), Arabidopsis thaliana
Manually annotated by BRENDA team
Krause, R.; Goldring, J.
Phosphoethanolamine-N-methyltransferase is a potential biomarker for the diagnosis of P. knowlesi and P. falciparum malaria
PLoS ONE
13
e0193833
2018
Plasmodium knowlesi, Plasmodium vivax (A5K867), Plasmodium vivax, Plasmodium falciparum (Q6T755), Plasmodium falciparum, Plasmodium vivax Salvador I (A5K867)
Manually annotated by BRENDA team
Witola, W.H.; Cooks-Fagbodun, S.; Ordonez, A.R.; Matthews, K.; Abugri, D.A.; McHugh, M.
Knockdown of phosphoethanolamine transmethylation enzymes decreases viability of Haemonchus contortus
Vet. Parasitol.
223
1-6
2016
Haemonchus contortus (A0A2Z1FIB9), Haemonchus contortus (U5HK48)
Manually annotated by BRENDA team