2.1.1.103: phosphoethanolamine N-methyltransferase
This is an abbreviated version!
For detailed information about phosphoethanolamine N-methyltransferase, go to the full flat file.
Word Map on EC 2.1.1.103
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2.1.1.103
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phosphatidylcholine
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phosphocholine
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choline
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phospholipid
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plasmodium
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falciparum
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malaria
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betaine
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s-adenosylhomocysteine
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plant-like
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osmoprotectant
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cdp-choline
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s-adenosylmethionine-dependent
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transmethylation
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medicine
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halophyte
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s-adenosyl-l-methionine-dependent
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nematicide
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amodiaquine
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drug development
- 2.1.1.103
- phosphatidylcholine
- phosphocholine
- choline
- phospholipid
- plasmodium
- falciparum
- malaria
- betaine
- s-adenosylhomocysteine
-
plant-like
-
osmoprotectant
- cdp-choline
-
s-adenosylmethionine-dependent
-
transmethylation
- medicine
-
halophyte
-
s-adenosyl-l-methionine-dependent
-
nematicide
- amodiaquine
- drug development
Reaction
Synonyms
AtNMT1, DPR2, More, NMT1, NMT2, PEAMT, PEAMT1, Pfpmt, phosphodimethylethanolamine methyltransferase, phosphoethanolamine methyltransferase, phosphoethanolamine N-methyltransferase, phosphoethanolamine-N-methyltransferases, phosphomethylethanolamine N-methyltransferase, PMEAMT, PMT, PMT-1, PMT1, PMT2, PVX_083045, S-adenosyl-L-methionine:phosphoethanolamine N-methyltransferase, SoPEAMT
ECTree
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Inhibitors
Inhibitors on EC 2.1.1.103 - phosphoethanolamine N-methyltransferase
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(3S)-1-(4-hydroxyphenyl)-N-[(2S)-1-[[2-(1H-indol-3-yl)ethyl]amino]-1-oxopropan-2-yl]-5-oxopyrrolidine-3-carboxamide
i.e. ZINC12882412. Compound has good druglike properties and affinity for Pmt and inhibits Plasmodium falciparum growth with IC50 value of 2.1 microM. It is nontoxic in vitro against HEK-293 cells
7-(3,5-dibromo-4-hydroxyphenethylamino)quinoline-5,8-dione
i.e. NSC-668394
N-methylethanolamine phosphate
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competitive inhibition versus both substrates
N-[5-[(9,10-dimethoxy-4-oxo-6,7-dihydro-4H-pyrimido[6,1-a]isoquinolin-2-yl)amino]pentyl]propanamide
i.e. ZINC02103914. Compound has good druglike properties and affinity for Pmt and inhibits Plasmodium falciparum growth with IC50 value of 3 microM. It is nontoxic in vitro against HEK-293 cells
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i.e. 4-[(7-chloroquinolin-4-yl)amino]-2-[(diethylamino)methyl]phenol
amodiaquine
i.e. 4-[(7-chloroquinolin-4-yl)amino]-2-[(diethylamino)methyl]phenol
miltefosine
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about 60% inhibition at 0.1 mM, complete loss of activity at 0.15 mM
compound displays significant anthelmintic activity against third-stage larvae (IC50 15 microM) and adult stages (IC50 2.9 microM); compound displays significant anthelmintic activity against third-stage larvae (IC50 15 microM) and adult stages (IC50 2.9 microM)
47% activity in the presence of 1 mM, 17% activity in the presence of 5 mM
73% activity in the presence of 0.01 mM, 18% activity in the presence of 0.2 mM
S-adenosyl-L-homocysteine
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competitive versus S-adenosyl-L-methionine, non-competitive versus ethanolamine phosphate; product inhibition versus SAM and phosphoethanolamine show competitive and non-competitive inhibition patterns, respectively
additional information
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isozyme PMT1 is not inhibited by diphenhydramine
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additional information
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not inhibited by 2,3-dichloro-methylbenzyl-amine, chloroquine, and dodecyltrimethylammonium at concentrations up to 0.1 mM
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