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2.1.1.103: phosphoethanolamine N-methyltransferase

This is an abbreviated version!
For detailed information about phosphoethanolamine N-methyltransferase, go to the full flat file.

Word Map on EC 2.1.1.103

Reaction

S-adenosyl-L-methionine
+
Ethanolamine phosphate
=
S-adenosyl-L-homocysteine
+
N-methylethanolamine phosphate

Synonyms

AtNMT1, DPR2, More, NMT1, NMT2, PEAMT, PEAMT1, Pfpmt, phosphodimethylethanolamine methyltransferase, phosphoethanolamine methyltransferase, phosphoethanolamine N-methyltransferase, phosphoethanolamine-N-methyltransferases, phosphomethylethanolamine N-methyltransferase, PMEAMT, PMT, PMT-1, PMT1, PMT2, PVX_083045, S-adenosyl-L-methionine:phosphoethanolamine N-methyltransferase, SoPEAMT

ECTree

     2 Transferases
         2.1 Transferring one-carbon groups
             2.1.1 Methyltransferases
                2.1.1.103 phosphoethanolamine N-methyltransferase

Inhibitors

Inhibitors on EC 2.1.1.103 - phosphoethanolamine N-methyltransferase

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INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
(3S)-1-(4-hydroxyphenyl)-N-[(2S)-1-[[2-(1H-indol-3-yl)ethyl]amino]-1-oxopropan-2-yl]-5-oxopyrrolidine-3-carboxamide
i.e. ZINC12882412. Compound has good druglike properties and affinity for Pmt and inhibits Plasmodium falciparum growth with IC50 value of 2.1 microM. It is nontoxic in vitro against HEK-293 cells
7-(3,5-dibromo-4-hydroxyphenethylamino)quinoline-5,8-dione
i.e. NSC-668394
amodiaquine
Chloroquine
diphenhydramine
-
i.e. 2-(diphenylmethoxy)-N,N-dimethylethanamine
dodecyltrimethylammonium
-
25% inhibition at 0.5 mM
hexadecyltrimethylammonium
-
about 50% inhibition at 0.1 mM
miltefosine
N-methylethanolamine phosphate
-
competitive inhibition versus both substrates
N-[5-[(9,10-dimethoxy-4-oxo-6,7-dihydro-4H-pyrimido[6,1-a]isoquinolin-2-yl)amino]pentyl]propanamide
i.e. ZINC02103914. Compound has good druglike properties and affinity for Pmt and inhibits Plasmodium falciparum growth with IC50 value of 3 microM. It is nontoxic in vitro against HEK-293 cells
NSC-158011
competitive inhibitor
NSC-641296
NSC158011
phosphate
-
-
phosphocholine
S-adenosyl-L-homocysteine
sinefungin
tacrine
-
i.e. 1,2,3,4-tetrahydroacridin-9-amine
additional information
-