2.1.1.103: phosphoethanolamine N-methyltransferase

This is an abbreviated version!
For detailed information about phosphoethanolamine N-methyltransferase, go to the full flat file.

Reaction

Synonyms

AtNMT1, DPR2, More, NMT1, NMT2, PEAMT, PEAMT1, Pfpmt, phosphodimethylethanolamine methyltransferase, phosphoethanolamine methyltransferase, phosphoethanolamine N-methyltransferase, phosphoethanolamine-N-methyltransferases, phosphomethylethanolamine N-methyltransferase, PMEAMT, PMT, PMT-1, PMT1, PMT2, PVX_083045, S-adenosyl-L-methionine:phosphoethanolamine N-methyltransferase, SoPEAMT

ECTree

     2 Transferases

         2.1 Transferring one-carbon groups

             2.1.1 Methyltransferases

                2.1.1.103 phosphoethanolamine N-methyltransferase

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Results	in table
2	Activating Compound
105	AA Sequence
6	Application
2	CAS Registry Number
30	Cloned(Commentary)
5	Cofactor
8	Crystallization (Commentary)
1	Expression
12	General Information
26	IC50 Value
53	Inhibitors
31	kcat/KM [mM/s]
8	Ki Value [mM]
57	KM Value [mM]
10	Localization
17	Molecular Weight [Da]
44	Natural Substrates/ Products (Substrates)
389	Organism
5	Pathway
7	PDB ID
5	pH Optimum
1	pH Range
4	pI Value
53	Protein Variants
16	Purification (Commentary)
2	Reaction
1	Reaction Type
58	Reference
20	Source Tissue
4	Specific Activity [micromol/min/mg]
159	Substrates and Products (Substrate)
25	Subunits
67	Synonyms
1	Systematic Name
2	Temperature Optimum [°C]
33	Turnover Number [1/s]

IC50 Value

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IC50 Value on EC 2.1.1.103 - phosphoethanolamine N-methyltransferase

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IC50 VALUE [mM]

INHIBITOR

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

IMAGE

0.009

(3S)-1-(4-hydroxyphenyl)-N-[(2S)-1-[[2-(1H-indol-3-yl)ethyl]amino]-1-oxopropan-2-yl]-5-oxopyrrolidine-3-carboxamide

Plasmodium falciparum

Q6T755

pH not specified in the publication, temperature not specified in the publication

756293

0.0028 - 0.0059

7-(3,5-dibromo-4-hydroxyphenethylamino)quinoline-5,8-dione

2 entries

0.22 - 3.4

amodiaquine

5 entries

0.146 - 0.554

Chloroquine

3 entries

0.013

diphenhydramine

Haemonchus contortus

-

isozyme PMT2, in 0.1 M HEPES (pH 8.0), 2 mM Na2EDTA, 10% glycerol, at 25°C

719978

0.0125 - 0.1252

miltefosine

2 entries

0.003

N-[5-[(9,10-dimethoxy-4-oxo-6,7-dihydro-4H-pyrimido[6,1-a]isoquinolin-2-yl)amino]pentyl]propanamide

Plasmodium falciparum

Q6T755

pH not specified in the publication, temperature not specified in the publication

756293

0.0008

NSC-22225

Plasmodium falciparum

Q8IDQ9

at pH 8.6 and 37°C

735175

0.005

NSC-39225

Plasmodium falciparum

Q8IDQ9

at pH 8.6 and 37°C

735175

0.0051 - 0.0083

NSC-641296

2 entries

0.05 - 0.099

NSC158011

2 entries

0.46

primaquine

Plasmodium falciparum

Q6T755

pH and temperature not specified in the publication

733477

0.0338 - 0.0915

sinefungin

2 entries

3.5 - 23.4

tacrine

2 entries

0.0028

7-(3,5-dibromo-4-hydroxyphenethylamino)quinoline-5,8-dione

Haemonchus contortus

A0A2Z1FIB9, U5HK48

combination of isoforms PMT1/PMT2, 24°C, pH not specified in the publication

758529

0.0059

7-(3,5-dibromo-4-hydroxyphenethylamino)quinoline-5,8-dione

Haemonchus contortus

A0A2Z1FIB9, U5HK48

isoform PMT1 alone, 24°C, pH not specified in the publication

758529

0.22

amodiaquine

Plasmodium vivax

A5K867

at pH 8.6 and 37°C

735267

0.398

amodiaquine

Plasmodium knowlesi

B3L8G9

at pH 8.6 and 37°C

735267

1.35

amodiaquine

Plasmodium falciparum

Q6T755

pH and temperature not specified in the publication

733477

3.1

amodiaquine

Haemonchus contortus

-

isozyme PMT2, in 0.1 M HEPES (pH 8.0), 2 mM Na2EDTA, 10% glycerol, at 25°C

719978

3.4

amodiaquine

Haemonchus contortus

-

isozyme PMT1, in 0.1 M HEPES (pH 8.0), 2 mM Na2EDTA, 10% glycerol, at 25°C

719978

0.146

Chloroquine

Plasmodium knowlesi

B3L8G9

at pH 8.6 and 37°C

735267

0.146

Chloroquine

Plasmodium vivax

A5K867

at pH 8.6 and 37°C

735267

0.554

Chloroquine

Plasmodium falciparum

Q6T755

pH and temperature not specified in the publication

733477

0.0125

miltefosine

Haemonchus contortus

-

isozyme PMT2, in 0.1 M HEPES (pH 8.0), 2 mM Na2EDTA, 10% glycerol, at 25°C

719978

0.1252

miltefosine

Haemonchus contortus

-

isozyme PMT1, in 0.1 M HEPES (pH 8.0), 2 mM Na2EDTA, 10% glycerol, at 25°C

719978

0.0051

NSC-641296

Haemonchus contortus

A0A2Z1FIB9, U5HK48

combination of isoforms PMT1/PMT2, 24°C, pH not specified in the publication

758529

0.0083

NSC-641296

Haemonchus contortus

A0A2Z1FIB9, U5HK48

isoform PMT1 alone, 24°C, pH not specified in the publication

758529

0.05

NSC158011

Plasmodium knowlesi

B3L8G9

at pH 8.6 and 37°C

735267

0.099

NSC158011

Plasmodium vivax

A5K867

at pH 8.6 and 37°C

735267

0.0338

sinefungin

Haemonchus contortus

-

isozyme PMT1, in 0.1 M HEPES (pH 8.0), 2 mM Na2EDTA, 10% glycerol, at 25°C

719978

0.0915

sinefungin

Haemonchus contortus

-

isozyme PMT2, in 0.1 M HEPES (pH 8.0), 2 mM Na2EDTA, 10% glycerol, at 25°C

719978

3.5

tacrine

Haemonchus contortus

-

isozyme PMT2, in 0.1 M HEPES (pH 8.0), 2 mM Na2EDTA, 10% glycerol, at 25°C

719978

23.4

tacrine

Haemonchus contortus

-

isozyme PMT1, in 0.1 M HEPES (pH 8.0), 2 mM Na2EDTA, 10% glycerol, at 25°C

719978