2.1.1.103: phosphoethanolamine N-methyltransferase
This is an abbreviated version!
For detailed information about phosphoethanolamine N-methyltransferase, go to the full flat file.
Word Map on EC 2.1.1.103
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2.1.1.103
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phosphatidylcholine
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phosphocholine
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choline
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phospholipid
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plasmodium
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falciparum
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malaria
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betaine
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s-adenosylhomocysteine
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plant-like
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osmoprotectant
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cdp-choline
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s-adenosylmethionine-dependent
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transmethylation
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medicine
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halophyte
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s-adenosyl-l-methionine-dependent
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nematicide
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amodiaquine
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drug development
- 2.1.1.103
- phosphatidylcholine
- phosphocholine
- choline
- phospholipid
- plasmodium
- falciparum
- malaria
- betaine
- s-adenosylhomocysteine
-
plant-like
-
osmoprotectant
- cdp-choline
-
s-adenosylmethionine-dependent
-
transmethylation
- medicine
-
halophyte
-
s-adenosyl-l-methionine-dependent
-
nematicide
- amodiaquine
- drug development
Reaction
Synonyms
AtNMT1, DPR2, More, NMT1, NMT2, PEAMT, PEAMT1, Pfpmt, phosphodimethylethanolamine methyltransferase, phosphoethanolamine methyltransferase, phosphoethanolamine N-methyltransferase, phosphoethanolamine-N-methyltransferases, phosphomethylethanolamine N-methyltransferase, PMEAMT, PMT, PMT-1, PMT1, PMT2, PVX_083045, S-adenosyl-L-methionine:phosphoethanolamine N-methyltransferase, SoPEAMT
ECTree
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Engineering
Engineering on EC 2.1.1.103 - phosphoethanolamine N-methyltransferase
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D128A
D128E
D128N
D128Q
compared to the wild type enzyme, the mutant shows almost complete loss of activity with phosphoethanolamine but not with the final substrate of the methylation pathway (about 89% activity)
D61A
D61E
site-directed mutagenesis, inactive mutant, which fails to complement the mutant Saccharomyces cerevisiae strain pem1DELTApem2DELTA, overview
D61N
G153A
site-directed mutagenesis, the PfPMT mutant complements the mutant Saccharomyces cerevisiae strain pem1DELTApem2DELTA, overview
G63A
site-directed mutagenesis, the PfPMT mutant complements the mutant Saccharomyces cerevisiae strain pem1DELTApem2DELTA, overview
G83A
site-directed mutagenesis, inactive mutant, which fails to complement the mutant Saccharomyces cerevisiae strain pem1DELTApem2DELTA, overview
R179A
additional information
site-directed mutagenesis, inactive mutant, which fails to complement the mutant Saccharomyces cerevisiae strain pem1DELTApem2DELTA, overview
D128A
compared to the wild type enzyme, the mutant shows almost complete loss of activity with phosphoethanolamine but not with the final substrate of the methylation pathway (about 91% activity)
site-directed mutagenesis, inactive mutant, which fails to complement the mutant Saccharomyces cerevisiae strain pem1DELTApem2DELTA, overview
D128E
compared to the wild type enzyme, the mutant shows about 90% loss of activity with phosphoethanolamine but not with the final substrate of the methylation pathway (about 182% activity)
site-directed mutagenesis, inactive mutant, which fails to complement the mutant Saccharomyces cerevisiae strain pem1DELTApem2DELTA, overview
D128N
compared to the wild type enzyme, the mutant shows complete loss of activity with phosphoethanolamine but not with the final substrate of the methylation pathway (about 24% activity)
site-directed mutagenesis, inactive mutant, which fails to complement the mutant Saccharomyces cerevisiae strain pem1DELTApem2DELTA, overview
site-directed mutagenesis, inactive mutant, which fails to complement the mutant Saccharomyces cerevisiae strain pem1DELTApem2DELTA, overview
Arabidopsis mutant strain t365 with silenced gene for EC 2.1.1.103 enzyme shows pale green leaves, early senescence, temperature-sensitive male sterility and hypersensitivity to salt stress
additional information
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gene pmt-1 knockout by RNAi, exposure to arsenite and phenotype in different developmental stages, overview
additional information
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construction of knockout mutants, disruption of the PfPMT gene results in a complete loss of phosphatidylcholine biosynthesis via the serine-decarboxylase phosphoethanolamine-methyltransferase, SDPM, pathway and severe growth and survival defects, phenotype, overview
additional information
deleting the C-terminal domain does not abolish ethanolamine phosphate reactivity, C-terminal domain catalyzes reactions with methylated ethanolamine phosphate
additional information
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deleting the C-terminal domain does not abolish ethanolamine phosphate reactivity, C-terminal domain catalyzes reactions with methylated ethanolamine phosphate
additional information
several point mutations and N- and C-terminal domains investigated, N-terminal domain catalyzes all three activities, regulatory role for C-terminal domain suggested
additional information
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several point mutations and N- and C-terminal domains investigated, N-terminal domain catalyzes all three activities, regulatory role for C-terminal domain suggested
additional information
overexpression of ZmPEAMT1 enhances the salt tolerance, root length, and silique number in transgenic Arabidopsis thaliana plants, phenotypes, overview