2.1.1.101: macrocin O-methyltransferase

This is an abbreviated version!
For detailed information about macrocin O-methyltransferase, go to the full flat file.

Reaction

Synonyms

macrocin methyltransferase, S-adenosyl-L-methionine-macrocin O-methyltransferase

ECTree

     2 Transferases

         2.1 Transferring one-carbon groups

             2.1.1 Methyltransferases

                2.1.1.101 macrocin O-methyltransferase

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Results	in table
76	AA Sequence
3	Application
1	CAS Registry Number
1	General Information
18	Inhibitors
11	Ki Value [mM]
6	KM Value [mM]
12	Metals/Ions
4	Molecular Weight [Da]
4	Natural Substrates/ Products (Substrates)
5	Organism
4	Pathway
4	pH Optimum
2	Purification (Commentary)
2	Reaction
1	Reaction Type
5	Reference
1	Specific Activity [micromol/min/mg]
4	Storage Stability
16	Substrates and Products (Substrate)
2	Subunits
2	Synonyms
1	Systematic Name
3	Temperature Optimum [°C]

Substrates Products

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Substrates Products on EC 2.1.1.101 - macrocin O-methyltransferase

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SUBSTRATE

PRODUCT                       

REACTION DIAGRAM

ORGANISM

UNIPROT

COMMENTARY
(Substrate)

LITERATURE
(Substrate)

COMMENTARY
(Product)

LITERATURE
(Product)

Reversibility
r=reversible
ir=irreversible
?=not specified

S-adenosyl-L-methionine + 20-dihydrolactenocin

S-adenosyl-L-homocysteine + ?

Streptomyces fradiae

-

-

485048

-

-

?

S-adenosyl-L-methionine + demethyllactenocin

S-adenosyl-L-homocysteine + 2'''-O-demethyldesmycosin

Streptomyces fradiae

Q9S4D5

-

757458

-

-

?

S-adenosyl-L-methionine + demethylmacrocin

S-adenosyl-L-homocysteine + 2'''-O-demethyltylosin

Streptomyces fradiae

Q9S4D5

-

757458

-

-

?

S-adenosyl-L-methionine + dihydromacrocin

S-adenosyl-L-homocysteine + ?

Streptomyces fradiae

-

-

485048

-

-

?

S-adenosyl-L-methionine + lactenocin

S-adenosyl-L-homocysteine + desmycosin

2 entries

S-adenosyl-L-methionine + macrocin

S-adenosyl-L-homocysteine + tylosin

Streptomyces fradiae

-

-

485047, 485048, 485049, 485050

-

-

?

S-adenosyl-L-methionine + macrocin

S-adenosylhomocysteine + tylosin

2 entries

additional information

?

-

Streptomyces fradiae

-

demethylmacrocin, demethyllactenocin, N5-methyltetrahydrofolate, betaine, choline, methylthioadenosine and methionine are not substrates

485048

-

-

?

S-adenosyl-L-methionine + lactenocin

S-adenosyl-L-homocysteine + desmycosin

Streptomyces fradiae

-

-

485048, 485050

-

-

?

S-adenosyl-L-methionine + lactenocin

S-adenosyl-L-homocysteine + desmycosin

Streptomyces fradiae

Q9S4D5

-

757458

-

-

?

S-adenosyl-L-methionine + macrocin

S-adenosylhomocysteine + tylosin

Streptomyces fradiae

-

enzyme catalyzes 3'''-O-methylation of bound 2'''-O-methylated 6-deoxy-D-allose

485050

-

-

?

S-adenosyl-L-methionine + macrocin

S-adenosylhomocysteine + tylosin

Streptomyces fradiae

-

terminal and main rate-limiting step in tylosin biosynthesis

485047, 485048, 485049

-

-

?