2.1.1.100: protein-S-isoprenylcysteine O-methyltransferase
This is an abbreviated version!
For detailed information about protein-S-isoprenylcysteine O-methyltransferase, go to the full flat file.
Word Map on EC 2.1.1.100
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2.1.1.100
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n-acetyl-s-farnesyl-l-cysteine
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cysmethynil
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medicine
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a-factor
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aax
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carboxylmethylation
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ste24p
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n-acetyl-s-geranylgeranyl-l-cysteine
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ras-driven
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biotechnology
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analysis
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drug development
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pharmacology
- 2.1.1.100
- n-acetyl-s-farnesyl-l-cysteine
- cysmethynil
- medicine
- a-factor
- aax
-
carboxylmethylation
- ste24p
- n-acetyl-s-geranylgeranyl-l-cysteine
-
ras-driven
- biotechnology
- analysis
- drug development
- pharmacology
Reaction
Synonyms
EC 2.1.1.24, farnesyl cysteine C-terminal methyltransferase, farnesyl-protein carboxymethyltransferase, farnesylated protein C-terminal O-methyltransferase, Icmt, isoprenylated protein methyltransferase, isoprenylcysteine carboxyl methyltransferase, isoprenylcysteine carboxylmethyltransferase, isoprenylcysteine carboxylmethyltransferase Ste14p, isoprenylcysteine methylesterase, methyltransferase, protein C-terminal farnesylcysteine O-, prenylated protein methyltransferase, protein S-farnesylcysteine C-terminal methyltransferase, S-farnesylcysteine methyltransferase, STE14A, STE14B, Ste14p
ECTree
2.1.1.100 protein-S-isoprenylcysteine O-methyltransferaseAdvanced search results
results (
results (KM Value
KM Value on EC 2.1.1.100 - protein-S-isoprenylcysteine O-methyltransferase
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KM VALUE [mM] 
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY 
LITERATURE
IMAGE
0.0059 - 0.0179
4-benzoyl-N-([2-[2-([5-[(3aS,4S,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl]pentanoyl]amino)ethoxy]ethoxy]acetyl)-L-phenylalanyl-S-[(2E,6E)-3,7,11-trimethyldodeca-2,6,10-trien-1-yl]-L-cysteine
0.0066
biotin-Peg4-K(5-Fam)YIIKGVFWDPAC(C10-Diazirine)-OH
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apparent value, at pH 7.5 and 30°C
0.0278
biotin-Peg4-K(5-Fam)YIIKGVFWDPAC(C5-m-BP)-OH
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apparent value, at pH 7.5 and 30°C
0.0146
biotin-Peg4-YIIKGVFWDPAC(C5-meta-Bp)
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IC50 above 0.1 mM, at pH 7.5 and 25°C
0.0061
biotin-Peg4-YIIKGVFWDPAC(C5-para-Bp)
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IC50 above 0.1 mM, at pH 7.5 and 25°C
0.0122
biotin-Peg4-YIIKGVFWDPAC(Fr)-OH
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apparent value, at pH 7.5 and 30°C
0.594
N-acetyl-S-geranylgeranyl-L-cysteinyl-L-alanyl-S-geranylgeranyl-L-cysteine
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-
0.0034 - 0.0183
S-[(2E,6E)-8-(3-benzoylphenoxy)-3,7-dimethylocta-2,6-dien-1-yl]-N-([2-[2-([5-[(3aS,4S,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl]pentanoyl]amino)ethoxy]ethoxy]acetyl)-D-cysteine
0.0059
4-benzoyl-N-([2-[2-([5-[(3aS,4S,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl]pentanoyl]amino)ethoxy]ethoxy]acetyl)-L-phenylalanyl-S-[(2E,6E)-3,7,11-trimethyldodeca-2,6,10-trien-1-yl]-L-cysteine
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at pH 7.5 and 25°C
0.0179
4-benzoyl-N-([2-[2-([5-[(3aS,4S,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl]pentanoyl]amino)ethoxy]ethoxy]acetyl)-L-phenylalanyl-S-[(2E,6E)-3,7,11-trimethyldodeca-2,6,10-trien-1-yl]-L-cysteine
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at pH 7.5 and 25°C
0.0159
N-acetyl-S-farnesyl-L-cysteine
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apparent value, at pH 7.5 and 30°C
0.0048
S-adenosyl-L-methionine
mutant enzyme F216Y, at pH 7.4 and 25°C
0.0094
S-adenosyl-L-methionine
mutant enzyme F216R, at pH 7.4 and 25°C
0.018
S-adenosyl-L-methionine
mutant enzyme Y107A, at pH 7.4 and 25°C
0.022
S-adenosyl-L-methionine
mutant enzyme F216A, at pH 7.4 and 25°C
0.026
S-adenosyl-L-methionine
mutant enzyme W240A, at pH 7.4 and 25°C
0.0034
S-[(2E,6E)-8-(3-benzoylphenoxy)-3,7-dimethylocta-2,6-dien-1-yl]-N-([2-[2-([5-[(3aS,4S,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl]pentanoyl]amino)ethoxy]ethoxy]acetyl)-D-cysteine
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at pH 7.5 and 25°C
0.0183
S-[(2E,6E)-8-(3-benzoylphenoxy)-3,7-dimethylocta-2,6-dien-1-yl]-N-([2-[2-([5-[(3aS,4S,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl]pentanoyl]amino)ethoxy]ethoxy]acetyl)-D-cysteine
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at pH 7.5 and 25°C
