2.1.1.100: protein-S-isoprenylcysteine O-methyltransferase
This is an abbreviated version!
For detailed information about protein-S-isoprenylcysteine O-methyltransferase, go to the full flat file.
Word Map on EC 2.1.1.100
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2.1.1.100
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n-acetyl-s-farnesyl-l-cysteine
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cysmethynil
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medicine
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a-factor
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aax
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carboxylmethylation
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ste24p
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n-acetyl-s-geranylgeranyl-l-cysteine
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ras-driven
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biotechnology
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analysis
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drug development
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pharmacology
- 2.1.1.100
- n-acetyl-s-farnesyl-l-cysteine
- cysmethynil
- medicine
- a-factor
- aax
-
carboxylmethylation
- ste24p
- n-acetyl-s-geranylgeranyl-l-cysteine
-
ras-driven
- biotechnology
- analysis
- drug development
- pharmacology
Reaction
Synonyms
EC 2.1.1.24, farnesyl cysteine C-terminal methyltransferase, farnesyl-protein carboxymethyltransferase, farnesylated protein C-terminal O-methyltransferase, Icmt, isoprenylated protein methyltransferase, isoprenylcysteine carboxyl methyltransferase, isoprenylcysteine carboxylmethyltransferase, isoprenylcysteine carboxylmethyltransferase Ste14p, isoprenylcysteine methylesterase, methyltransferase, protein C-terminal farnesylcysteine O-, prenylated protein methyltransferase, protein S-farnesylcysteine C-terminal methyltransferase, S-farnesylcysteine methyltransferase, STE14A, STE14B, Ste14p
ECTree
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KI Value
KI Value on EC 2.1.1.100 - protein-S-isoprenylcysteine O-methyltransferase
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0.0004
methyl 3-[[(2E)-5-[4-[2-(biphenyl-4-yl)ethyl]-1H-1,2,3-triazol-1-yl]-3-methylpent-2-en-1-yl]sulfanyl]propanoate
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pH and temperature not specified in the publication
0.0354 - 0.6144
N-Acetyl-S-(3-(3-methylbut-2-enyl)-5-(4-phenyl)phenylpent-2Z-en-1-yl)-L-cysteine
0.0171
N-acetyl-S-(3-(3-methylbut-2-enyl)-7,11-dimethyldodeca-2Z,6E,10-trien-1-yl)-L-cysteine
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0.0026
N-acetyl-S-(E,E)-farnesyl-L-cysteine
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competitive vs. N-acetyl-S-(E,E)-geranylgeranyl-L-cysteine
0.0023
N-acetyl-S-(E,E)-geranylgeranyl-L-cysteine
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competitive vs. N-acetyl-S-(E,E)-farnesyl-L-cysteine
0.0039
S-(Geranylgeranyl-2-thio)acetic acid
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competitive vs. N-acetyl-S-(E,E)-farnesyl-L-cysteine
0.0011
substrate N-acetyl-S-farnesyl cysteine, pH not specified in the publication, temperature not specified in the publication
0.0029
4-[(naphthalen-2-yl)(thiophen-2-yl)methylidene]oxane
substrate S-adenosyl-L-methionine, pH not specified in the publication, temperature not specified in the publication
0.0022
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with respect to farnesylated and Rce1-proteolyzed K-Ras protein as substrate
0.00239
cysmethynil
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with respect to S-adenosyl-L-methionine as substrate
0.0354
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competitive inhibition
0.1193
N-Acetyl-S-(3-(3-methylbut-2-enyl)-5-(4-phenyl)phenylpent-2Z-en-1-yl)-L-cysteine
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competitive inhibition
0.3772
N-Acetyl-S-(3-(3-methylbut-2-enyl)-5-(4-phenyl)phenylpent-2Z-en-1-yl)-L-cysteine
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uncompetitive inhibition
0.6144
N-Acetyl-S-(3-(3-methylbut-2-enyl)-5-(4-phenyl)phenylpent-2Z-en-1-yl)-L-cysteine
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uncompetitive inhibition
0.00207
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mixed-type vs. N-acetyl-S-farnesyl-L-cysteine
0.0021
N-acetyl-S-farnesyl-L-cysteine methyl ester
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with respect to biotin-S-farnesyl-L-cysteine
0.00243
N-acetyl-S-farnesyl-L-cysteine methyl ester
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with respect to S-adenosyl-L-methionine
0.005
N-acetyl-S-farnesyl-L-cysteine methyl ester
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competitive vs. S-adenosyl-L-methionine
0.00359
S-adenosyl-L-homocysteine
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with respect to biotin-S-farnesyl-L-cysteine
0.0044
S-adenosyl-L-homocysteine
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mixed-type vs. N-acetyl-S-farnesyl-L-cysteine
0.00658
S-adenosyl-L-homocysteine
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inhibition of N-acetyl-S-(E,E)-farnesyl-L-cysteine methylation
0.0115
S-adenosyl-L-homocysteine
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inhibition of N-acetyl-S-geranylgeranyl-L-cysteinyl-L-alanyl-S-geranylgeranyl-L-cysteine
0.00645
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inhibition of N-acetyl-S-(E,E)-farnesyl-L-cysteine methylation
0.0218
S-adenosylethionine
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inhibition of N-acetyl-S-geranylgeranyl-L-cysteinyl-L-alanyl-S-geranylgeranyl-L-cysteine
0.0046
S-Farnesylthioacetic acid
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competitive vs. N-acetyl-S-(E,E)-farnesyl-L-cysteine
0.0112
S-Farnesylthioacetic acid
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inhibition of N-acetyl-S-(E,E)-farnesyl-L-cysteine methylation
0.0137
S-Farnesylthioacetic acid
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competitive vs. N-acetyl-S-farnesyl-L-cysteine
0.000296
sinefungin
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inhibition of N-acetyl-S-geranylgeranyl-L-cysteinyl-L-alanyl-S-geranylgeranyl-L-cysteine
0.000318
sinefungin
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inhibition of N-acetyl-S-(E,E)-farnesyl-L-cysteine methylation