2.1.1.100: protein-S-isoprenylcysteine O-methyltransferase

This is an abbreviated version!
For detailed information about protein-S-isoprenylcysteine O-methyltransferase, go to the full flat file.

Reaction

Synonyms

EC 2.1.1.24, farnesyl cysteine C-terminal methyltransferase, farnesyl-protein carboxymethyltransferase, farnesylated protein C-terminal O-methyltransferase, Icmt, isoprenylated protein methyltransferase, isoprenylcysteine carboxyl methyltransferase, isoprenylcysteine carboxylmethyltransferase, isoprenylcysteine carboxylmethyltransferase Ste14p, isoprenylcysteine methylesterase, methyltransferase, protein C-terminal farnesylcysteine O-, prenylated protein methyltransferase, protein S-farnesylcysteine C-terminal methyltransferase, S-farnesylcysteine methyltransferase, STE14A, STE14B, Ste14p

ECTree

     2 Transferases

         2.1 Transferring one-carbon groups

             2.1.1 Methyltransferases

                2.1.1.100 protein-S-isoprenylcysteine O-methyltransferase

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Results	in table
6	Activating Compound
5180	AA Sequence
16	Application
1	CAS Registry Number
17	Cloned(Commentary)
3	Cofactor
115	Disease/ Diagnostics
2	Expression
13	General Information
2	General Stability
217	IC50 Value
371	Inhibitors
46	Ki Value [mM]
74	KM Value [mM]
33	Localization
2	Metals/Ions
12	Molecular Weight [Da]
21	Natural Substrates/ Products (Substrates)
75	Organism
2	Pathway
2	PDB ID
5	pH Optimum
2	pH Range
1	pH Stability
33	Protein Variants
7	Purification (Commentary)
3	Reaction
1	Reaction Type
74	Reference
61	Source Tissue
3	Specific Activity [micromol/min/mg]
1	Storage Stability
121	Substrates and Products (Substrate)
9	Subunits
88	Synonyms
1	Systematic Name
1	Temperature Optimum [°C]
1	Temperature Range [°C]
3	Turnover Number [1/s]

KI Value

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KI Value on EC 2.1.1.100 - protein-S-isoprenylcysteine O-methyltransferase

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Ki VALUE [mM]

INHIBITOR

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

IMAGE

0.0011 - 0.0029

4-[(naphthalen-2-yl)(thiophen-2-yl)methylidene]oxane

2 entries

3.95

5'-deoxymethylthioadenosine

Homo sapiens

-

-

485032

0.0022 - 0.00239

cysmethynil

2 entries

0.0004

methyl 3-[[(2E)-5-[4-[2-(biphenyl-4-yl)ethyl]-1H-1,2,3-triazol-1-yl]-3-methylpent-2-en-1-yl]sulfanyl]propanoate

Homo sapiens

-

pH and temperature not specified in the publication

718467

0.0354 - 0.6144

N-Acetyl-S-(3-(3-methylbut-2-enyl)-5-(4-phenyl)phenylpent-2Z-en-1-yl)-L-cysteine

4 entries

0.0171

N-acetyl-S-(3-(3-methylbut-2-enyl)-7,11-dimethyldodeca-2Z,6E,10-trien-1-yl)-L-cysteine

Saccharomyces cerevisiae

-

-

674465

0.0026

N-acetyl-S-(E,E)-farnesyl-L-cysteine

Bos taurus

-

competitive vs. N-acetyl-S-(E,E)-geranylgeranyl-L-cysteine

485026

0.041

N-acetyl-S-(E,E)-farnesyl-L-cysteine methyl ester

Bos taurus

-

-

485025

0.0023

N-acetyl-S-(E,E)-geranylgeranyl-L-cysteine

Bos taurus

-

competitive vs. N-acetyl-S-(E,E)-farnesyl-L-cysteine

485026

0.00207 - 0.005

N-acetyl-S-farnesyl-L-cysteine methyl ester

4 entries

0.0039

S-(Geranylgeranyl-2-thio)acetic acid

Bos taurus

-

competitive vs. N-acetyl-S-(E,E)-farnesyl-L-cysteine

485026

0.00157 - 1.8

S-adenosyl-L-homocysteine

11 entries

0.00645 - 0.0218

S-adenosylethionine

2 entries

0.0028

S-farnesyl thiosalicylic acid

Rattus norvegicus

-

-

485038

0.028

S-farnesyl-4-chlorothiosalicylic acid

Rattus norvegicus

-

-

485038

0.023

S-farnesyl-4-fluorothiosalicylic acid

Rattus norvegicus

-

-

485038

0.0085

S-farnesyl-5-chlorothiosalicylic acid

Rattus norvegicus

-

-

485038

0.0063

S-farnesyl-5-fluorothiosalicylic acid

Rattus norvegicus

-

-

485038

0.00117 - 0.0137

S-Farnesylthioacetic acid

6 entries

0.00007 - 0.000318

sinefungin

3 entries

0.0011

4-[(naphthalen-2-yl)(thiophen-2-yl)methylidene]oxane

Homo sapiens

O60725

substrate N-acetyl-S-farnesyl cysteine, pH not specified in the publication, temperature not specified in the publication

757563

0.0029

4-[(naphthalen-2-yl)(thiophen-2-yl)methylidene]oxane

Homo sapiens

O60725

substrate S-adenosyl-L-methionine, pH not specified in the publication, temperature not specified in the publication

757563

0.0022

cysmethynil

Spodoptera frugiperda

-

with respect to farnesylated and Rce1-proteolyzed K-Ras protein as substrate

672255

0.00239

cysmethynil

Spodoptera frugiperda

-

with respect to S-adenosyl-L-methionine as substrate

672255

0.0354

N-Acetyl-S-(3-(3-methylbut-2-enyl)-5-(4-phenyl)phenylpent-2Z-en-1-yl)-L-cysteine

Saccharomyces cerevisiae

-

competitive inhibition

674465

0.1193

N-Acetyl-S-(3-(3-methylbut-2-enyl)-5-(4-phenyl)phenylpent-2Z-en-1-yl)-L-cysteine

Homo sapiens

-

competitive inhibition

674465

0.3772

N-Acetyl-S-(3-(3-methylbut-2-enyl)-5-(4-phenyl)phenylpent-2Z-en-1-yl)-L-cysteine

Homo sapiens

-

uncompetitive inhibition

674465

0.6144

N-Acetyl-S-(3-(3-methylbut-2-enyl)-5-(4-phenyl)phenylpent-2Z-en-1-yl)-L-cysteine

Saccharomyces cerevisiae

-

uncompetitive inhibition

674465

0.00207

N-acetyl-S-farnesyl-L-cysteine methyl ester

Homo sapiens

-

mixed-type vs. N-acetyl-S-farnesyl-L-cysteine

485034

0.0021

N-acetyl-S-farnesyl-L-cysteine methyl ester

Homo sapiens

-

with respect to biotin-S-farnesyl-L-cysteine

658348

0.00243

N-acetyl-S-farnesyl-L-cysteine methyl ester

Homo sapiens

-

with respect to S-adenosyl-L-methionine

658348

0.005

N-acetyl-S-farnesyl-L-cysteine methyl ester

Homo sapiens

-

competitive vs. S-adenosyl-L-methionine

485034

0.00157

S-adenosyl-L-homocysteine

Homo sapiens

-

-

485032

0.0019

S-adenosyl-L-homocysteine

Bos taurus

-

vs. S-adenosyl-L-methionine

485025

0.0033

S-adenosyl-L-homocysteine

Bos taurus

-

vs. N-acetyl-S-(E,E)-farnesyl-L-cysteine

485025

0.00354

S-adenosyl-L-homocysteine

Homo sapiens

-

with respect to S-adenosyl-L-methionine

658348

0.00359

S-adenosyl-L-homocysteine

Homo sapiens

-

with respect to biotin-S-farnesyl-L-cysteine

658348

0.00413

S-adenosyl-L-homocysteine

Homo sapiens

-

competitive vs. S-adenosyl-L-methionine

485034

0.0044

S-adenosyl-L-homocysteine

Homo sapiens

-

mixed-type vs. N-acetyl-S-farnesyl-L-cysteine

485034

0.00658

S-adenosyl-L-homocysteine

Bos taurus

-

inhibition of N-acetyl-S-(E,E)-farnesyl-L-cysteine methylation

485033

0.0092

S-adenosyl-L-homocysteine

Rattus norvegicus

-

-

485021

0.0115

S-adenosyl-L-homocysteine

Bos taurus

-

inhibition of N-acetyl-S-geranylgeranyl-L-cysteinyl-L-alanyl-S-geranylgeranyl-L-cysteine

485033

1.8

S-adenosyl-L-homocysteine

Bos taurus

-

-

485035

0.00645

S-adenosylethionine

Bos taurus

-

inhibition of N-acetyl-S-(E,E)-farnesyl-L-cysteine methylation

485033

0.0218

S-adenosylethionine

Bos taurus

-

inhibition of N-acetyl-S-geranylgeranyl-L-cysteinyl-L-alanyl-S-geranylgeranyl-L-cysteine

485033

0.00117

S-Farnesylthioacetic acid

Homo sapiens

-

-

658348

0.0012

S-Farnesylthioacetic acid

Bos taurus

-

-

485025

0.002

S-Farnesylthioacetic acid

Homo sapiens

-

-

485031

0.0046

S-Farnesylthioacetic acid

Bos taurus

-

competitive vs. N-acetyl-S-(E,E)-farnesyl-L-cysteine

485026

0.0112

S-Farnesylthioacetic acid

Bos taurus

-

inhibition of N-acetyl-S-(E,E)-farnesyl-L-cysteine methylation

485033

0.0137

S-Farnesylthioacetic acid

Homo sapiens

-

competitive vs. N-acetyl-S-farnesyl-L-cysteine

485034

0.00007

sinefungin

Homo sapiens

-

-

485032

0.000296

sinefungin

Bos taurus

-

inhibition of N-acetyl-S-geranylgeranyl-L-cysteinyl-L-alanyl-S-geranylgeranyl-L-cysteine

485033

0.000318

sinefungin

Bos taurus

-

inhibition of N-acetyl-S-(E,E)-farnesyl-L-cysteine methylation

485033