2.1.1.100: protein-S-isoprenylcysteine O-methyltransferase

This is an abbreviated version!
For detailed information about protein-S-isoprenylcysteine O-methyltransferase, go to the full flat file.

Word Map on EC 2.1.1.100

2.1.1.100

n-acetyl-s-farnesyl-l-cysteine

cysmethynil

medicine

a-factor

aax

carboxylmethylation

ste24p

n-acetyl-s-geranylgeranyl-l-cysteine

ras-driven

biotechnology

analysis

drug development

pharmacology

Reaction

protein C-terminal S-farnesyl-L-cysteine

protein C-terminal S-farnesyl-L-cysteine methyl ester

Synonyms

EC 2.1.1.24, farnesyl cysteine C-terminal methyltransferase, farnesyl-protein carboxymethyltransferase, farnesylated protein C-terminal O-methyltransferase, Icmt, isoprenylated protein methyltransferase, isoprenylcysteine carboxyl methyltransferase, isoprenylcysteine carboxylmethyltransferase, isoprenylcysteine carboxylmethyltransferase Ste14p, isoprenylcysteine methylesterase, methyltransferase, protein C-terminal farnesylcysteine O-, prenylated protein methyltransferase, protein S-farnesylcysteine C-terminal methyltransferase, S-farnesylcysteine methyltransferase, STE14A, STE14B, Ste14p

ECTree

2 Transferases

2.1 Transferring one-carbon groups

2.1.1 Methyltransferases

2.1.1.100 protein-S-isoprenylcysteine O-methyltransferase

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Results	in table
6	Activating Compound
5180	AA Sequence
16	Application
1	CAS Registry Number
17	Cloned(Commentary)
3	Cofactor
115	Disease/ Diagnostics
2	Expression
13	General Information
2	General Stability
217	IC50 Value
371	Inhibitors
46	Ki Value [mM]
74	KM Value [mM]
33	Localization
2	Metals/Ions
12	Molecular Weight [Da]
21	Natural Substrates/ Products (Substrates)
75	Organism
2	Pathway
2	PDB ID
5	pH Optimum
2	pH Range
1	pH Stability
33	Protein Variants
7	Purification (Commentary)
3	Reaction
1	Reaction Type
74	Reference
61	Source Tissue
3	Specific Activity [micromol/min/mg]
1	Storage Stability
121	Substrates and Products (Substrate)
9	Subunits
88	Synonyms
1	Systematic Name
1	Temperature Optimum [°C]
1	Temperature Range [°C]
3	Turnover Number [1/s]

IC50 Value

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IC50 Value on EC 2.1.1.100 - protein-S-isoprenylcysteine O-methyltransferase

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0.0007

(1-octyl-5-m-tolyl-1H-indol-3-yl)methanamine

Homo sapiens

in 100 mM HEPES buffer pH 7.4, 5 mM MgCl2, and 0.1 mM EDTA, at 37°C

720184

0.000031

(3,5-difluoro-4-methoxyphenyl)-[2-(2,2-dimethyl-4-phenyltetrahydropyran-4-yl)ethyl]amine

Homo sapiens

in 100 mM HEPES, pH 7.5, 5 mM MgCl2, at 22°C

720191

0.000025

(3-chloro-4-fluorophenyl)-[2-(2,2-dimethyl-4-phenyltetrahydropyran-4-yl)ethyl]amine

Homo sapiens

in 100 mM HEPES, pH 7.5, 5 mM MgCl2, at 22°C

720191

0.0000038

(3-chlorophenyl)-[2-(2,2-dimethyl-4-thiophen-2-yltetrahydropyran-4-yl)ethyl]amine

Homo sapiens

in 100 mM HEPES, pH 7.5, 5 mM MgCl2, at 22°C

720191

0.00047

(4-chloro-3-fluorophenyl)-[2-(2,2-dimethyl-4-phenyltetrahydropyran-4-yl)ethyl]amine

Homo sapiens

in 100 mM HEPES, pH 7.5, 5 mM MgCl2, at 22°C

720191

0.000032

(5-chloro-2-fluorophenyl)-[2-(2,2-dimethyl-4-phenyltetrahydropyran-4-yl)ethyl]amine

Homo sapiens

in 100 mM HEPES, pH 7.5, 5 mM MgCl2, at 22°C

720191

0.049

(R)-2-(2-((benzyloxy)methyl)benzamido)-3-(((2E,6E)-3,7,11-trimethyldodeca-2,6,10-trien-1-yl)-thio)propanoic acid

Homo sapiens

in 100 mM Tris-HCl, pH 7.5, at 30°C

719091

0.075

(R)-2-(2-(phenoxymethyl)benzamido)-3-(((2E,6E)-3,7,11-trimethyldodeca-2,6,10-trien-1-yl)thio)propanoic acid

Homo sapiens

in 100 mM Tris-HCl, pH 7.5, at 30°C

719091

0.0147

(R)-2-(2-(phenylthio)benzamido)-3-(((2E,6E)-3,7,11-trimethyldodeca-2,6,10-trien-1-yl)thio)propanoic acid

Homo sapiens

in 100 mM Tris-HCl, pH 7.5, at 30°C

719091

0.038

(R)-2-(2-benzylbenzamido)-3-(((2E,6E)-3,7,11-trimethyldodeca-2,6,10-trien-1-yl)thio)propanoic acid

Homo sapiens

in 100 mM Tris-HCl, pH 7.5, at 30°C

719091

0.038

(R)-2-(2-phenoxybenzamido)-3-(((2E,6E,10E)-3,7,11,15-tetramethylhexadeca-2,6,10,14-tetraen-1-yl)thio)propanoic acid

Homo sapiens

in 100 mM Tris-HCl, pH 7.5, at 30°C

719091

0.21

(R)-2-(2-phenoxybenzamido)-3-(undecylthio)propanoic acid

Homo sapiens

in 100 mM Tris-HCl, pH 7.5, at 30°C

719091

0.0226

(R)-2-(3-phenoxybenzamido)-3-(((2E,6E)-3,7,11-trimethyldodeca-2,6,10-trien-1-yl)thio)propanoic acid

Homo sapiens

in 100 mM Tris-HCl, pH 7.5, at 30°C

719091

0.063

(R)-2-(4-phenoxybenzamido)-3-(((2E,6E)-3,7,11-trimethyldodeca-2,6,10-trien-1-yl)thio)propanoic acid

Homo sapiens

in 100 mM Tris-HCl, pH 7.5, at 30°C

719091

0.058

(R)-2-(dibenzo[b,d]furan-4-carboxamido)-3-(((2E,6E)-3,7,11-trimethyldodeca-2,6,10-trien-1-yl)thio)-propanoic acid

Homo sapiens

in 100 mM Tris-HCl, pH 7.5, at 30°C

719091

0.0067

(R)-2-(N-methyl-2-phenoxybenzamido)-3-(((2E,6E)-3,7,11-trimethyldodeca-2,6,10-trien-1-yl)thio)propanoic acid

Homo sapiens

in 100 mM Tris-HCl, pH 7.5, at 30°C

719091

0.149

(R,E)-3-((3,7-dimethylocta-2,6-dien-1-yl)thio)-2-(2-phenoxybenzamido)propanoic acid

Homo sapiens

in 100 mM Tris-HCl, pH 7.5, at 30°C

719091

0.0078

(S)-2-(2-phenoxybenzamido)-3-(((2E,6E)-3,7,11-trimethyldodeca-2,6,10-trien-1-yl)thio)propanoic acid

Homo sapiens

in 100 mM Tris-HCl, pH 7.5, at 30°C

719091

0.025

(S)-glabrol

Homo sapiens

706119

0.001

1-(2,2-dimethyl-4-phenyltetrahydropyran-4-yl)-3-(3-fluorophenyl)thiourea

Homo sapiens

IC50 above 0.001 mM, in 100 mM HEPES, pH 7.5, 5 mM MgCl2, at 22°C

720191

0.001

1-(2,2-dimethyl-4-phenyltetrahydropyran-4-yl)-3-(3-methoxphenyl)urea

Homo sapiens

IC50 above 0.001 mM, in 100 mM HEPES, pH 7.5, 5 mM MgCl2, at 22°C

720191

1-(2,2-dimethyl-4-phenyltetrahydropyran-4-yl)-3-(3-methoxyphenyl)thiourea

Homo sapiens

IC50 above 0.001 mM, in 100 mM HEPES, pH 7.5, 5 mM MgCl2, at 22°C

720191

0.001

1-(2,2-dimethyl-4-phenyltetrahydropyran-4-yl)-3-phenylthiourea

Homo sapiens

IC50 above 0.001 mM, in 100 mM HEPES, pH 7.5, 5 mM MgCl2, at 22°C

720191

0.002

1-(2-methylidenebut-3-en-1-yl)-5-(3-methylphenyl)-3-(morpholin-4-ylmethyl)-1H-indole

Homo sapiens

in 100 mM HEPES buffer pH 7.4, 5 mM MgCl2, and 0.1 mM EDTA, at 37°C

720184

0.0021

1-(2-methylidenebut-3-en-1-yl)-5-(3-methylphenyl)-3-(piperidin-1-ylmethyl)-1H-indole

Homo sapiens

in 100 mM HEPES buffer pH 7.4, 5 mM MgCl2, and 0.1 mM EDTA, at 37°C

720184

0.002

1-(2-methylidenebut-3-en-1-yl)-5-(3-methylphenyl)-3-[(morpholin-4-yl)methyl]-1H-indole

Homo sapiens

pH and temperature not specified in the publication

734514

0.0021

1-(2-methylidenebut-3-en-1-yl)-5-(3-methylphenyl)-3-[(piperidin-1-yl)methyl]-1H-indole

Homo sapiens

pH and temperature not specified in the publication

734514

1-(3-chlorophenyl)-3-(2,2-dimethyl-4-phenyltetrahydropyran-4-yl)thiourea

Homo sapiens

IC50 above 0.001 mM, in 100 mM HEPES, pH 7.5, 5 mM MgCl2, at 22°C

720191

1-(3-chlorophenyl)-3-(2,2-dimethyl-4-phenyltetrahydropyran-4-yl)urea

Homo sapiens

IC50 above 0.001 mM, in 100 mM HEPES, pH 7.5, 5 mM MgCl2, at 22°C

720191

0.1

1-(3-methylbut-2-enyl)-5-m-tolyl-1H-indole

Homo sapiens

IC50 above 0.1 mM, in 100 mM HEPES buffer pH 7.4, 5 mM MgCl2, and 0.1 mM EDTA, at 37°C

720184

0.1

1-octyl-5-m-tolyl-1H-indole

Homo sapiens

IC50 above 0.1 mM, in 100 mM HEPES buffer pH 7.4, 5 mM MgCl2, and 0.1 mM EDTA, at 37°C

720184

0.03

1-octyl-5-m-tolyl-1H-indole-3-carboxamide

Homo sapiens

in 100 mM HEPES buffer pH 7.4, 5 mM MgCl2, and 0.1 mM EDTA, at 37°C

720184

0.0007

1-[5-(3-methylphenyl)-1-octyl-1H-indol-3-yl]methanamine

Homo sapiens

pH and temperature not specified in the publication

734514

0.017

2'-methoxy-3',3''-diprenyl-licodione

Homo sapiens

706119

0.03

2'-methoxy-3'-prenyllicodione

Homo sapiens

706119

0.0065

2-(1-octyl-1H-indol-3-yl)acetamide

2 entries

0.0018

2-(1-octyl-5-phenyl-1H-indol-3-yl)acetamide

2 entries

0.005

2-(2,2-dimethyl-4-phenyltetrahydropyran-4-yl)-N-(3-methoxyphenyl)acetamide

Homo sapiens

IC50 above 0.005 mM, in 100 mM HEPES, pH 7.5, 5 mM MgCl2, at 22°C

720191

0.005

2-(2,2-dimethyl-4-phenyltetrahydropyran-4-yl)-N-phenylacetamide

Homo sapiens

IC50 above 0.005 mM, in 100 mM HEPES, pH 7.5, 5 mM MgCl2, at 22°C

720191

0.001

2-(5-(3-ethoxyphenyl)-1-octyl-1H-indol-3-yl)-N,N-diethylacetamide

Homo sapiens

in 100 mM HEPES buffer pH 7.4, 5 mM MgCl2, and 0.1 mM EDTA, at 37°C

720184

0.069

2-(5-fluoro-1-(3-methylbut-2-enyl)-1H-indol-3-yl)acetamide

Homo sapiens

in 100 mM HEPES buffer pH 7.4, 5 mM MgCl2, and 0.1 mM EDTA, at 37°C

720184

0.007

2-(5-fluoro-1-octyl-1H-indol-3-yl)acetamide

Homo sapiens

in 100 mM HEPES buffer pH 7.4, 5 mM MgCl2, and 0.1 mM EDTA, at 37°C

720184

1.1

2-Carboxy-2'-hydroxy-5'-sulfoformazylbenzene

Saccharomyces cerevisiae

IC50: 1.1 mM

659510

0.0062

2-phenoxy-phenylfarnesylcysteine

Homo sapiens

in 100 mM Tris-HCl, pH 7.5, at 30°C

719091

0.0077

2-[1-(2-methylidenebut-3-en-1-yl)-5-(3-methylphenyl)-1H-indol-3-yl]acetamide

Homo sapiens

pH and temperature not specified in the publication

734514

0.0011

2-[1-[(2E,6E)-2,6-dimethylocta-2,6-dien-1-yl]-5-(3-methylphenyl)-1H-indol-3-yl]acetamide

Homo sapiens

pH and temperature not specified in the publication

734514

0.001

2-[5-(2-methylphenyl)-1-octyl-1H-indol-3-yl]acetamide

2 entries

0.001

2-[5-(3-ethoxyphenyl)-1-octyl-1H-indol-3-yl]-N,N-diethylacetamide

Homo sapiens

pH and temperature not specified in the publication

734514

0.0013

2-[5-(3-ethoxyphenyl)-1-octyl-1H-indol-3-yl]acetamide

Homo sapiens

in 100 mM HEPES buffer pH 7.4, 5 mM MgCl2, and 0.1 mM EDTA, at 37°C

720184

0.0013

2-[5-(3-ethylphenyl)-1-octyl-1H-indol-3-yl]acetamide

Homo sapiens

pH and temperature not specified in the publication

734514

0.069

2-[5-(3-fluorophenyl)-1-(2-methylidenebut-3-en-1-yl)-1H-indol-3-yl]acetamide

Homo sapiens

pH and temperature not specified in the publication

734514

0.007

2-[5-(3-fluorophenyl)-1-octyl-1H-indol-3-yl]acetamide

Homo sapiens

pH and temperature not specified in the publication

734514

0.0019

2-[5-(3-methoxyphenyl)-1-octyl-1H-indol-3-yl]acetamide

2 entries

0.0017

2-[5-(3-methylphenyl)-1-octyl-1H-indol-3-yl]-1-(4-methylpiperazin-1-yl)ethan-1-one

Homo sapiens

pH and temperature not specified in the publication

734514

0.0017

2-[5-(3-methylphenyl)-1-octyl-1H-indol-3-yl]-1-(4-methylpiperazin-1-yl)ethanone

Homo sapiens

in 100 mM HEPES buffer pH 7.4, 5 mM MgCl2, and 0.1 mM EDTA, at 37°C

720184

0.0018

2-[5-(3-methylphenyl)-1-octyl-1H-indol-3-yl]-1-(piperidin-1-yl)ethan-1-one

Homo sapiens

pH and temperature not specified in the publication

734514

0.0018

2-[5-(3-methylphenyl)-1-octyl-1H-indol-3-yl]-1-(piperidin-1-yl)ethanone

Homo sapiens

in 100 mM HEPES buffer pH 7.4, 5 mM MgCl2, and 0.1 mM EDTA, at 37°C

720184

0.0012

2-[5-(3-methylphenyl)-1-octyl-1H-indol-3-yl]-1-(pyrrolidin-1-yl)ethan-1-one

Homo sapiens

pH and temperature not specified in the publication

734514

0.0012

2-[5-(3-methylphenyl)-1-octyl-1H-indol-3-yl]-1-(pyrrolidin-1-yl)ethanone

Homo sapiens

in 100 mM HEPES buffer pH 7.4, 5 mM MgCl2, and 0.1 mM EDTA, at 37°C

720184

0.0015

2-[5-(3-methylphenyl)-1-octyl-1H-indol-3-yl]acetamide

Homo sapiens

pH and temperature not specified in the publication

734514

0.0025

2-[5-(3-methylphenyl)-1-[3-(trifluoromethyl)benzyl]-1H-indol-3-yl]acetamide

Homo sapiens

in 100 mM HEPES buffer pH 7.4, 5 mM MgCl2, and 0.1 mM EDTA, at 37°C

720184

0.0025

2-[5-(3-methylphenyl)-1-[[3-(trifluoromethyl)phenyl]methyl]-1H-indol-3-yl]acetamide

Homo sapiens

pH and temperature not specified in the publication

734514

0.033

2-[5-(3-methylphenyl)-1H-indol-3-yl]acetamide

2 entries

0.001

2-[5-(4-methylphenyl)-1-octyl-1H-indol-3-yl]acetamide

2 entries

0.00031

2-[[2-(2,2-dimethyl-4-phenyltetrahydro-2H-pyran-4-yl)ethyl](phenyl)amino]-1-(furan-2-yl)ethanone

Homo sapiens

in 100 mM HEPES, pH 7.5, 5 mM MgCl2, at 22°C

720191

0.000181

3,4-dichloro-N-[2-(2,2-dimethyl-4-phenyltetrahydro-2Hpyran-4-yl)ethyl]aniline

Homo sapiens

in 100 mM HEPES, pH 7.5, 5 mM MgCl2, at 22°C

720191

0.00017

3,5-dichloro-N-[2-(2,2-dimethyl-4-phenyltetrahydro-2H-pyran-4-yl)ethyl]aniline

Homo sapiens

in 100 mM HEPES, pH 7.5, 5 mM MgCl2, at 22°C

720191

0.0012

3-(1-octyl-5-m-tolyl-1H-indol-3-yl)propanamide

Homo sapiens

in 100 mM HEPES buffer pH 7.4, 5 mM MgCl2, and 0.1 mM EDTA, at 37°C

720184

0.001

3-chloro-4-methyl-N-[2-(2,2,6,6-tetramethyl-4-phenyl-4-piperidyl)ethyl]aniline

Homo sapiens

IC50 above 0.001 mM, in 100 mM HEPES, pH 7.5, 5 mM MgCl2, at 22°C

720191

0.00046

3-chloro-4-methyl-N-[2-(4-phenyltetrahydro-2H-pyran-4-yl)-ethyl]aniline

Homo sapiens

in 100 mM HEPES, pH 7.5, 5 mM MgCl2, at 22°C

720191

0.005

3-chloro-N-(3-chlorophenyl)-N-[2-(2,2,6,6-tetramethyl-4-phenyltetrahydropyran-4-yl)ethyl]aniline

Homo sapiens

IC50 above 0.005 mM, in 100 mM HEPES, pH 7.5, 5 mM MgCl2, at 22°C

720191

0.001

3-chloro-N-[2-(2,2,6,6-tetramethyl-4-phenyl-4-piperidyl)-ethyl]aniline

Homo sapiens

IC50 above 0.001 mM, in 100 mM HEPES, pH 7.5, 5 mM MgCl2, at 22°C

720191

0.00249

3-chloro-N-[2-(2,2,6,6-tetramethyl-4-phenyltetrahydrothiopyran-4-yl)ethyl]aniline

Homo sapiens

in 100 mM HEPES, pH 7.5, 5 mM MgCl2, at 22°C

720191

0.000049

3-chloro-N-[2-(2,2-dimethyl-4-phenyltetrahydro-2H-pyran-4-yl)ethyl]-4-methylaniline

Homo sapiens

in 100 mM HEPES, pH 7.5, 5 mM MgCl2, at 22°C

720191

0.000025

3-chloro-N-[2-(2,2-dimethyl-4-phenyltetrahydro-2H-pyran-4-yl)ethyl]aniline

Homo sapiens

in 100 mM HEPES, pH 7.5, 5 mM MgCl2, at 22°C

720191

0.00383

3-chloro-N-[2-(4-phenyltetrahydro-2H-pyran-4-yl)ethyl]-aniline

Homo sapiens

in 100 mM HEPES, pH 7.5, 5 mM MgCl2, at 22°C

720191

0.001

3-fluoro-N-[2-(2,2,6,6-tetramethyl-4-phenyl-4-piperidyl)-ethyl]aniline

Homo sapiens

IC50 above 0.001 mM, in 100 mM HEPES, pH 7.5, 5 mM MgCl2, at 22°C

720191

0.00325

3-fluoro-N-[2-(4-phenyltetrahydro-2H-pyran-4-yl)ethyl]-aniline

Homo sapiens

in 100 mM HEPES, pH 7.5, 5 mM MgCl2, at 22°C

720191

0.001

3-methoxy-N-[2-(2,2,6,6-tetramethyl-4-phenyl-4-piperidyl)-ethyl]aniline

Homo sapiens

IC50 above 0.001 mM, in 100 mM HEPES, pH 7.5, 5 mM MgCl2, at 22°C

720191

0.0000013

3-methoxy-N-[2-(2,2,6,6-tetramethyl-4-phenyltetrahydropyran-4-yl)ethyl]aniline

Homo sapiens

in 100 mM HEPES, pH 7.5, 5 mM MgCl2, at 22°C

720191

0.00042

3-methoxy-N-[2-(2,2,6,6-tetramethyl-4-phenyltetrahydrothiopyran-4-yl)ethyl]aniline

Homo sapiens

in 100 mM HEPES, pH 7.5, 5 mM MgCl2, at 22°C

720191

0.000777

3-methoxy-N-[2-(4-phenyltetrahydro-2H-pyran-4-yl)ethyl]-aniline

Homo sapiens

in 100 mM HEPES, pH 7.5, 5 mM MgCl2, at 22°C

720191

0.0125

3-methoxy-N-[2-[4-(4-methoxyphenyl)-2,2-dimethyltetrahydro-2H-pyran-4-yl]ethyl]aniline

Homo sapiens

in 100 mM HEPES, pH 7.5, 5 mM MgCl2, at 22°C

720191

0.00325

3-methyl-N-[2-(4-phenyltetrahydro-2H-pyran-4-yl)ethyl]-aniline

Homo sapiens

in 100 mM HEPES, pH 7.5, 5 mM MgCl2, at 22°C

720191

0.000556

3-tert-butyl-N-[2-(2,2-dimethyl-4-phenyltetrahydro-2H-pyran-4-yl)ethyl]aniline

Homo sapiens

in 100 mM HEPES, pH 7.5, 5 mM MgCl2, at 22°C

720191

0.005

3-[2-(2,2-dimethyl-4-phenyltetrahydropyran-4-yl)ethylamino]benzoic acid

Homo sapiens

IC50 above 0.005 mM, in 100 mM HEPES, pH 7.5, 5 mM MgCl2, at 22°C

720191

0.005

3-[2-(2,2-dimethyl-4-phenyltetrahydropyran-4-yl)ethylamino]phenol

Homo sapiens

IC50 above 0.005 mM, in 100 mM HEPES, pH 7.5, 5 mM MgCl2, at 22°C

720191

0.00245

3-[3-[(diethylamino)methyl]-1-octyl-1H-indol-5-yl]phenol

Homo sapiens

at pH 7.4 and 37°C

733780

0.0012

3-[5-(3-methylphenyl)-1-octyl-1H-indol-3-yl]propanamide

Homo sapiens

pH and temperature not specified in the publication

734514

0.00383

3-[[2-(2,2-dimethyl-4-phenyltetrahydro-2H-pyran-4-yl)-ethyl]amino]-N,N-dimethylbenzenesulfonamide

Homo sapiens

in 100 mM HEPES, pH 7.5, 5 mM MgCl2, at 22°C

720191

0.000066

3-[[2-(2,2-dimethyl-4-phenyltetrahydro-2H-pyran-4-yl)-ethyl]amino]benzonitrile

Homo sapiens

in 100 mM HEPES, pH 7.5, 5 mM MgCl2, at 22°C

720191

0.000308

4-chloro-N-[2-(2,2-dimethyl-4-phenyltetrahydro-2H-pyran-4-yl)ethyl]-3-methylaniline

Homo sapiens

in 100 mM HEPES, pH 7.5, 5 mM MgCl2, at 22°C

720191

0.00036

4-chloro-N-[2-(2,2-dimethyl-4-phenyltetrahydro-2H-pyran-4-yl)ethyl]aniline

Homo sapiens

in 100 mM HEPES, pH 7.5, 5 mM MgCl2, at 22°C

720191

0.00076

4-tert-butyl-N-[2-(2,2-dimethyl-4-phenyltetrahydro-2H-pyran-4-yl)ethyl]aniline

Homo sapiens

in 100 mM HEPES, pH 7.5, 5 mM MgCl2, at 22°C

720191

0.0015

4-[(naphthalen-2-yl)(thiophen-2-yl)methylidene]oxane

Homo sapiens

O60725

pH not specified in the publication, temperature not specified in the publication

757563

0.00171

4-[3-[(diethylamino)methyl]-1-octyl-1H-indol-5-yl]-N-methylbenzene-1-sulfonamide

Homo sapiens

at pH 7.4 and 37°C

733780

0.0131

4-[[2-(2,2-dimethyl-4-phenyltetrahydro-2H-pyran-4-yl)-ethyl]amino]benzenesulfonamide

Homo sapiens

in 100 mM HEPES, pH 7.5, 5 mM MgCl2, at 22°C

720191

0.000123

4-[[2-(2,2-dimethyl-4-phenyltetrahydro-2H-pyran-4-yl)-ethyl]amino]benzonitrile

Homo sapiens

in 100 mM HEPES, pH 7.5, 5 mM MgCl2, at 22°C

720191

0.03

5-(3-methylphenyl)-1-octyl-1H-indole-3-carboxamide

Homo sapiens

pH and temperature not specified in the publication

734514

0.0007

5-(3-methylphenyl)-1-octyl-3-(piperidin-1-ylmethyl)-1H-indole

Homo sapiens

in 100 mM HEPES buffer pH 7.4, 5 mM MgCl2, and 0.1 mM EDTA, at 37°C

720184

0.0005

5-(3-methylphenyl)-1-octyl-3-(pyrrolidin-1-ylmethyl)-1H-indole

Homo sapiens

in 100 mM HEPES buffer pH 7.4, 5 mM MgCl2, and 0.1 mM EDTA, at 37°C

720184

0.0007

5-(3-methylphenyl)-1-octyl-3-[(piperidin-1-yl)methyl]-1H-indole

Homo sapiens

pH and temperature not specified in the publication

734514

0.0005

5-(3-methylphenyl)-1-octyl-3-[(pyrrolidin-1-yl)methyl]-1H-indole

Homo sapiens

pH and temperature not specified in the publication

734514

0.0027

5-(3-methylphenyl)-3-(morpholin-4-ylmethyl)-1-octyl-1H-indole

Homo sapiens

in 100 mM HEPES buffer pH 7.4, 5 mM MgCl2, and 0.1 mM EDTA, at 37°C

720184

0.0009

5-(3-methylphenyl)-3-[(4-methylpiperazin-1-yl)methyl]-1-octyl-1H-indole

2 entries

0.0027

5-(3-methylphenyl)-3-[(morpholin-4-yl)methyl]-1-octyl-1H-indole

Homo sapiens

pH and temperature not specified in the publication

734514

0.00163

5-[3-[(diethylamino)methyl]-1-octyl-1H-indol-5-yl]-N,N-dimethylpyridin-2-amine

Homo sapiens

at pH 7.4 and 37°C

733780

0.00086

5-[3-[(diethylamino)methyl]-1-octyl-1H-indol-5-yl]pyrimidin-2-amine

Homo sapiens

at pH 7.4 and 37°C

733780

0.00226

5-[3-[(diethylamino)methyl]-1-octyl-1H-indol-5-yl]pyrimidine-2-carbonitrile

Homo sapiens

at pH 7.4 and 37°C

733780

0.0257

biotin-Peg4-YIIKGVFWDPAC(C10-meta-Bp)

Saccharomyces cerevisiae

at pH 7.5 and 25°C

733252

0.0137

biotin-Peg4-YIIKGVFWDPAC(C10-para-Bp)

Saccharomyces cerevisiae

at pH 7.5 and 25°C

733252

0.1

biotin-Peg4-YIIKGVFWDPAC(C5-meta-Bp)

Saccharomyces cerevisiae

IC50 above 0.1 mM, at pH 7.5 and 25°C

733252

0.1

biotin-Peg4-YIIKGVFWDPAC(C5-para-Bp)

Saccharomyces cerevisiae

IC50 above 0.1 mM, at pH 7.5 and 25°C

733252

0.0015 - 0.0019

cysmethynil

2 entries

0.00288

ethyl 4-[[2-(2,2-dimethyl-4-phenyltetrahydro-2H-pyran-4-yl)ethyl]amino]benzoate

Homo sapiens

in 100 mM HEPES, pH 7.5, 5 mM MgCl2, at 22°C

720191

0.1

ethyl [5-(3-methylphenyl)-1-octyl-1H-indol-3-yl]acetate

Homo sapiens

IC50 above 0.1 mM, in 100 mM HEPES buffer pH 7.4, 5 mM MgCl2, and 0.1 mM EDTA, at 37°C

720184

0.076

methyl [5-(3-methylphenyl)-1-octyl-1H-indol-3-yl]acetate

2 entries

0.000131

N'-[2-(2,2-dimethyl-4-phenyltetrahydro-2H-pyran-4-yl)-ethyl]-N,N-dimethylbenzene-1,3-diamine

Homo sapiens

in 100 mM HEPES, pH 7.5, 5 mM MgCl2, at 22°C

720191

0.0008

N,N-diethyl-2-(5-(3-methoxyphenyl)-1-octyl-1H-indol-3-yl)acetamide

Homo sapiens

in 100 mM HEPES buffer pH 7.4, 5 mM MgCl2, and 0.1 mM EDTA, at 37°C

720184

0.0008

N,N-diethyl-2-[5-(3-methoxyphenyl)-1-octyl-1H-indol-3-yl]acetamide

Homo sapiens

pH and temperature not specified in the publication

734514

0.0014

N,N-diethyl-2-[5-(3-methylphenyl)-1-octyl-1H-indol-3-yl]acetamide

2 entries

0.0013

N,N-dimethyl-1-[5-(3-methylphenyl)-1-octyl-1H-indol-3-yl]methanamine

2 entries

0.0015

N,N-dimethyl-2-[5-(3-methylphenyl)-1-octyl-1H-indol-3-yl]acetamide

2 entries

0.0012

N-((1-octyl-5-m-tolyl-1H-indol-3-yl)methyl)methanesulfonamide

Homo sapiens

in 100 mM HEPES buffer pH 7.4, 5 mM MgCl2, and 0.1 mM EDTA, at 37°C

720184

0.0077

N-(2-methylidenebut-3-en-1-yl)-2-[5-(3-methylphenyl)-1-[3-(trifluoromethyl)benzyl]-1H-indol-3-yl]acetamide

Homo sapiens

in 100 mM HEPES buffer pH 7.4, 5 mM MgCl2, and 0.1 mM EDTA, at 37°C

720184

0.0194

N-(2-phenoxybenzoyl)-3-[4-[(2E,6E)-3,7,11-trimethyldodeca-2,6,10-trien-1-yl]-1H-1,2,3-triazol-1-yl]-L-alanine

Homo sapiens

pH and temperature not specified in the publication

719060

0.005

N-(3-chlorophenyl)-2-(2,2-dimethyl-4-phenyltetrahydropyran-4-yl)acetamide

Homo sapiens

IC50 above 0.005 mM, in 100 mM HEPES, pH 7.5, 5 mM MgCl2, at 22°C

720191

0.00135

N-(3-[[2-(2,2-dimethyl-4-phenyltetrahydro-2H-pyran-4-yl)-ethyl]amino]phenyl)acetamide

Homo sapiens

in 100 mM HEPES, pH 7.5, 5 mM MgCl2, at 22°C

720191

0.0346

N-acetyl-S-[(2E)-3-methyl-5-(4-octylphenyl)pent-2-en-1-yl]-L-cysteine

Homo sapiens

pH and temperature not specified in the publication

719060

0.00012

N-benzyl-N-[2-(2,2-dimethyl-4-phenyltetrahydro-2H-pyran-4-yl)ethyl]furan-2-carboxamide

Homo sapiens

in 100 mM HEPES, pH 7.5, 5 mM MgCl2, at 22°C

720191

0.067

N-ethyl-N-((1-(3-methylbut-2-enyl)-1H-indol-3-yl)methyl) ethanamine

Homo sapiens

in 100 mM HEPES buffer pH 7.4, 5 mM MgCl2, and 0.1 mM EDTA, at 37°C

720184

0.035

N-ethyl-N-((5-fluoro-1-(3-methylbut-2-enyl)-1H-indol-3-yl)methyl)ethanamine

Homo sapiens

in 100 mM HEPES buffer pH 7.4, 5 mM MgCl2, and 0.1 mM EDTA, at 37°C

720184

0.00261

N-ethyl-N-([1-octyl-5-[3-(trifluoromethyl)phenyl]-1H-indol-3-yl]methyl)ethanamine

Homo sapiens

at pH 7.4 and 37°C

733780

0.00172

N-ethyl-N-([5-[4-(methanesulfonyl)phenyl]-1-octyl-1H-indol-3-yl]methyl)ethanamine

Homo sapiens

at pH 7.4 and 37°C

733780

0.00442

N-ethyl-N-[(4-fluoro-1-octyl-1H-indol-3-yl)methyl]ethanamine

Homo sapiens

at pH 7.4 and 37°C

733780

0.0041

N-ethyl-N-[(5-fluoro-1-octyl-1H-indol-3-yl)methyl]-ethanamine

Homo sapiens

in 100 mM HEPES buffer pH 7.4, 5 mM MgCl2, and 0.1 mM EDTA, at 37°C

720184

0.00483

N-ethyl-N-[(5-fluoro-1-octyl-1H-indol-3-yl)methyl]ethanamine

Homo sapiens

at pH 7.4 and 37°C

733780

0.00222

N-ethyl-N-[(6-fluoro-1-octyl-1H-indol-3-yl)methyl]ethanamine

Homo sapiens

at pH 7.4 and 37°C

733780

0.00227

N-ethyl-N-[(7-fluoro-1-octyl-1H-indol-3-yl)methyl]ethanamine

Homo sapiens

at pH 7.4 and 37°C

733780

0.067

N-ethyl-N-[[1-(2-methylidenebut-3-en-1-yl)-1H-indol-3-yl]methyl]ethanamine

Homo sapiens

pH and temperature not specified in the publication

734514

0.0024

N-ethyl-N-[[1-(2-methylidenebut-3-en-1-yl)-5-(3-methylphenyl)-1H-indol-3-yl]methyl]ethanamine

2 entries

0.00175

N-ethyl-N-[[1-octyl-5-(pyridin-3-yl)-1H-indol-3-yl]methyl]ethanamine

Homo sapiens

at pH 7.4 and 37°C

733780

0.00158

N-ethyl-N-[[1-octyl-5-(pyrimidin-5-yl)-1H-indol-3-yl]methyl]ethanamine

Homo sapiens

at pH 7.4 and 37°C

733780

0.00256

N-ethyl-N-[[5-(2-fluorophenyl)-1-octyl-1H-indol-3-yl]methyl]ethanamine

Homo sapiens

at pH 7.4 and 37°C

733780

0.0006

N-ethyl-N-[[5-(2-methylphenyl)-1-octyl-1H-indol-3-yl]methyl]ethanamine

2 entries

0.035

N-ethyl-N-[[5-(3-fluorophenyl)-1-(2-methylidenebut-3-en-1-yl)-1H-indol-3-yl]methyl]ethanamine

Homo sapiens

pH and temperature not specified in the publication

734514

0.00161 - 0.0041

N-ethyl-N-[[5-(3-fluorophenyl)-1-octyl-1H-indol-3-yl]methyl]ethanamine

2 entries

0.00096

N-ethyl-N-[[5-(3-fluoropyridin-4-yl)-1-octyl-1H-indol-3-yl]methyl]ethanamine

Homo sapiens

at pH 7.4 and 37°C

733780

0.0007 - 0.00218

N-ethyl-N-[[5-(3-methylphenyl)-1-octyl-1H-indol-3-yl]methyl]ethanamine

3 entries

0.0006

N-ethyl-N-[[5-(4-methylphenyl)-1-octyl-1H-indol-3-yl]methyl]ethanamine

2 entries

0.0009

N-methyl-N-[[5-(3-methylphenyl)-1-octyl-1H-indol-3-yl]methyl]propan-2-amine

2 entries

0.0018

N-[(1-octyl-5-m-tolyl-1H-indol-3-yl)methyl]acetamide

Homo sapiens

in 100 mM HEPES buffer pH 7.4, 5 mM MgCl2, and 0.1 mM EDTA, at 37°C

720184

0.0011

N-[(2E)-3,7-dimethylocta-2,6-dien-1-yl]-2-[5-(3-methylphenyl)-1-[3-(trifluoromethyl)benzyl]-1H-indol-3-yl]acetamide

Homo sapiens

in 100 mM HEPES buffer pH 7.4, 5 mM MgCl2, and 0.1 mM EDTA, at 37°C

720184

0.000015

N-[2-(2,2,6,6-tetramethyl-4-phenyltetrahydropyran-4-yl)-ethyl]aniline

Homo sapiens

in 100 mM HEPES, pH 7.5, 5 mM MgCl2, at 22°C

720191

0.001

N-[2-(2,2,6,6-tetramethyl-4-phenyltetrahydrothiopyran-4-yl)ethyl]aniline

Homo sapiens

IC50 above 0.001 mM, in 100 mM HEPES, pH 7.5, 5 mM MgCl2, at 22°C

720191

0.0036

N-[2-(2,2-dimethyl-4-phenyltetrahydro-2H-pyran-4-yl)-ethyl]-2-methylaniline

Homo sapiens

in 100 mM HEPES, pH 7.5, 5 mM MgCl2, at 22°C

720191

0.000652

N-[2-(2,2-dimethyl-4-phenyltetrahydro-2H-pyran-4-yl)-ethyl]-3,4-dimethoxyaniline

Homo sapiens

in 100 mM HEPES, pH 7.5, 5 mM MgCl2, at 22°C

720191

0.000054

N-[2-(2,2-dimethyl-4-phenyltetrahydro-2H-pyran-4-yl)-ethyl]-3,5-dimethylaniline

Homo sapiens

in 100 mM HEPES, pH 7.5, 5 mM MgCl2, at 22°C

720191

0.00009

N-[2-(2,2-dimethyl-4-phenyltetrahydro-2H-pyran-4-yl)-ethyl]-3-(trifluoromethoxy)aniline

Homo sapiens

in 100 mM HEPES, pH 7.5, 5 mM MgCl2, at 22°C

720191

0.00038

N-[2-(2,2-dimethyl-4-phenyltetrahydro-2H-pyran-4-yl)-ethyl]-3-(trifluoromethyl)aniline

Homo sapiens

in 100 mM HEPES, pH 7.5, 5 mM MgCl2, at 22°C

720191

0.00004

N-[2-(2,2-dimethyl-4-phenyltetrahydro-2H-pyran-4-yl)-ethyl]-3-ethylaniline

Homo sapiens

in 100 mM HEPES, pH 7.5, 5 mM MgCl2, at 22°C

720191

0.000052

N-[2-(2,2-dimethyl-4-phenyltetrahydro-2H-pyran-4-yl)-ethyl]-3-fluoroaniline

Homo sapiens

in 100 mM HEPES, pH 7.5, 5 mM MgCl2, at 22°C

720191

0.000167

N-[2-(2,2-dimethyl-4-phenyltetrahydro-2H-pyran-4-yl)-ethyl]-3-isopropylaniline

Homo sapiens

in 100 mM HEPES, pH 7.5, 5 mM MgCl2, at 22°C

720191

0.00009

N-[2-(2,2-dimethyl-4-phenyltetrahydro-2H-pyran-4-yl)-ethyl]-3-methoxy-4-methylaniline

Homo sapiens

in 100 mM HEPES, pH 7.5, 5 mM MgCl2, at 22°C

720191

0.000015

N-[2-(2,2-dimethyl-4-phenyltetrahydro-2H-pyran-4-yl)-ethyl]-3-methoxyaniline

Homo sapiens

in 100 mM HEPES, pH 7.5, 5 mM MgCl2, at 22°C

720191

0.000031

N-[2-(2,2-dimethyl-4-phenyltetrahydro-2H-pyran-4-yl)-ethyl]-3-methylaniline

Homo sapiens

in 100 mM HEPES, pH 7.5, 5 mM MgCl2, at 22°C

720191

0.000184

N-[2-(2,2-dimethyl-4-phenyltetrahydro-2H-pyran-4-yl)-ethyl]-4-(trifluoromethoxy)aniline

Homo sapiens

in 100 mM HEPES, pH 7.5, 5 mM MgCl2, at 22°C

720191

0.000168

N-[2-(2,2-dimethyl-4-phenyltetrahydro-2H-pyran-4-yl)-ethyl]-4-fluoroaniline

Homo sapiens

in 100 mM HEPES, pH 7.5, 5 mM MgCl2, at 22°C

720191

0.000132

N-[2-(2,2-dimethyl-4-phenyltetrahydro-2H-pyran-4-yl)-ethyl]-4-isopropylaniline

Homo sapiens

in 100 mM HEPES, pH 7.5, 5 mM MgCl2, at 22°C

720191

0.00027

N-[2-(2,2-dimethyl-4-phenyltetrahydro-2H-pyran-4-yl)-ethyl]-4-methoxyaniline

Homo sapiens

in 100 mM HEPES, pH 7.5, 5 mM MgCl2, at 22°C

720191

0.000031

N-[2-(2,2-dimethyl-4-phenyltetrahydro-2H-pyran-4-yl)-ethyl]-4-methylaniline

Homo sapiens

in 100 mM HEPES, pH 7.5, 5 mM MgCl2, at 22°C

720191

0.00985

N-[2-(2,2-dimethyl-4-phenyltetrahydro-2H-pyran-4-yl)-ethyl]-N,3-dimethylaniline

Homo sapiens

in 100 mM HEPES, pH 7.5, 5 mM MgCl2, at 22°C

720191

0.01

N-[2-(2,2-dimethyl-4-phenyltetrahydro-2H-pyran-4-yl)-ethyl]-N-methylaniline

Homo sapiens

IC50 above 0.01 mM, in 100 mM HEPES, pH 7.5, 5 mM MgCl2, at 22°C

720191

0.00234

N-[2-(2,2-dimethyl-4-phenyltetrahydro-2H-pyran-4-yl)-ethyl]-N-phenylacetamide

Homo sapiens

in 100 mM HEPES, pH 7.5, 5 mM MgCl2, at 22°C

720191

0.0027

N-[2-(2,2-dimethyl-4-phenyltetrahydro-2H-pyran-4-yl)-ethyl]aniline

Homo sapiens

in 100 mM HEPES, pH 7.5, 5 mM MgCl2, at 22°C

720191

0.000069

N-[2-(2,2-dimethyl-4-phenyltetrahydro-2H-pyran-4-yl)ethyl]-3,4-dimethylaniline

Homo sapiens

in 100 mM HEPES, pH 7.5, 5 mM MgCl2, at 22°C

720191

0.000026

N-[2-(2,2-dimethyl-4-phenyltetrahydro-2H-pyran-4-yl)ethyl]-3-nitroaniline

Homo sapiens

in 100 mM HEPES, pH 7.5, 5 mM MgCl2, at 22°C

720191

0.000682

N-[2-(2,2-dimethyl-4-phenyltetrahydro-2H-pyran-4-yl)ethyl]-4-nitroaniline

Homo sapiens

in 100 mM HEPES, pH 7.5, 5 mM MgCl2, at 22°C

720191

0.0134

N-[2-(benzyloxy)benzoyl]-S-[(2E,6E)-3,7,11-trimethyldodeca-2,6,10-trien-1-yl]-L-cysteine

Homo sapiens

in 100 mM Tris-HCl, pH 7.5, at 30°C

719091

0.0035

N-[3-(2,2-dimethyltetrahydro-2H-pyran-4-yl)-3-(2-methoxyphenyl)propyl]-N-(4-methoxybenzyl)furan-2-carboxamide

Homo sapiens

in 100 mM HEPES, pH 7.5, 5 mM MgCl2, at 22°C

720191

0.0017

N-[[5-(3-methylphenyl)-1-octyl-1H-indol-3-yl]methyl]-N-(propan-2-yl)propan-2-amine

2 entries

0.0008

N-[[5-(3-methylphenyl)-1-octyl-1H-indol-3-yl]methyl]-N-propylpropan-1-amine

2 entries

0.0018

N-[[5-(3-methylphenyl)-1-octyl-1H-indol-3-yl]methyl]acetamide

Homo sapiens

pH and temperature not specified in the publication

734514

0.0012

N-[[5-(3-methylphenyl)-1-octyl-1H-indol-3-yl]methyl]methanesulfonamide

Homo sapiens

pH and temperature not specified in the publication

734514

0.00543

S-[(2E,6E)-8-(3-benzoylphenoxy)-3,7-dimethylocta-2,6-dien-1-yl]-N-([2-[2-([5-[(3aS,4S,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl]pentanoyl]amino)ethoxy]ethoxy]acetyl)-D-cysteine

Homo sapiens

at pH 7.4 and 37°C

733780

0.0025

S-{(2E)-3-[2-(biphenyl-4-yl)ethyl]-6-methylhepta-2,5-dien-1-yl}-N-(2-phenoxybenzoyl)-L-homocysteine

Homo sapiens

in 100 mM Tris-HCl, pH 7.5, at 30°C

719091

0.00419

[2-(2,2-dimethyl-4-p-tolyltetrahydropyran-4-yl)ethyl]-(3-methoxyphenyl)amine

Homo sapiens

in 100 mM HEPES, pH 7.5, 5 mM MgCl2, at 22°C

720191

0.00055

[2-(2,2-dimethyl-4-phenyltetrahydro-2H-pyran-4-yl)ethyl]-(2-fluorophenyl)amine

Homo sapiens

in 100 mM HEPES, pH 7.5, 5 mM MgCl2, at 22°C

720191

0.0003

[2-(2,2-dimethyl-4-phenyltetrahydropyran-4-yl)ethyl]-(2-fluoro-4-methylphenyl)amine

Homo sapiens

in 100 mM HEPES, pH 7.5, 5 mM MgCl2, at 22°C

720191

0.00016

[2-(2,2-dimethyl-4-phenyltetrahydropyran-4-yl)ethyl]-(3-fluoro-4-methoxyphenyl)amine

Homo sapiens

in 100 mM HEPES, pH 7.5, 5 mM MgCl2, at 22°C

720191

0.000019

[2-(2,2-dimethyl-4-thiophen-2-yltetrahydropyran-4-yl)-ethyl]-(3-methoxyphenyl)amine

Homo sapiens

in 100 mM HEPES, pH 7.5, 5 mM MgCl2, at 22°C

720191

0.00027

[2-(2,2-dimethyl-4-thiophen-2-yltetrahydropyran-4-yl)-ethyl]phenylamine

Homo sapiens

in 100 mM HEPES, pH 7.5, 5 mM MgCl2, at 22°C

720191

0.00019

[2-[4-(3-chlorophenyl)-2,2-dimethyltetrahydropyran-4-yl]-ethyl]-(3-methoxyphenyl)amine

Homo sapiens

in 100 mM HEPES, pH 7.5, 5 mM MgCl2, at 22°C

720191

0.000008

[2-[4-(3-fluoro-phenyl)-2,2-dimethyltetrahydropyran-4-yl]-ethyl]-(3-methoxyphenyl)amine

Homo sapiens

in 100 mM HEPES, pH 7.5, 5 mM MgCl2, at 22°C

720191

0.00063

[2-[4-(4-chlorophenyl)-2,2-dimethyltetrahydropyran-4-yl]-ethyl]-(3-methoxyphenyl)amine

Homo sapiens

in 100 mM HEPES, pH 7.5, 5 mM MgCl2, at 22°C

720191

0.0001

[2-[4-(4-fluorophenyl)-2,2-dimethyltetrahydropyran-4-yl]-ethyl]-(3-methoxyphenyl)amine

Homo sapiens

in 100 mM HEPES, pH 7.5, 5 mM MgCl2, at 22°C

720191