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2.1.1.100: protein-S-isoprenylcysteine O-methyltransferase

This is an abbreviated version!
For detailed information about protein-S-isoprenylcysteine O-methyltransferase, go to the full flat file.

Word Map on EC 2.1.1.100

Reaction

S-adenosyl-L-methionine
+
protein C-terminal S-farnesyl-L-cysteine
=
S-adenosyl-L-homocysteine
 +
protein C-terminal S-farnesyl-L-cysteine methyl ester

Synonyms

EC 2.1.1.24, farnesyl cysteine C-terminal methyltransferase, farnesyl-protein carboxymethyltransferase, farnesylated protein C-terminal O-methyltransferase, Icmt, isoprenylated protein methyltransferase, isoprenylcysteine carboxyl methyltransferase, isoprenylcysteine carboxylmethyltransferase, isoprenylcysteine carboxylmethyltransferase Ste14p, isoprenylcysteine methylesterase, methyltransferase, protein C-terminal farnesylcysteine O-, prenylated protein methyltransferase, protein S-farnesylcysteine C-terminal methyltransferase, S-farnesylcysteine methyltransferase, STE14A, STE14B, Ste14p

ECTree

     2 Transferases
         2.1 Transferring one-carbon groups
             2.1.1 Methyltransferases
                2.1.1.100 protein-S-isoprenylcysteine O-methyltransferase

Cloned

Cloned on EC 2.1.1.100 - protein-S-isoprenylcysteine O-methyltransferase

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CLONED (Commentary)
ORGANISM
UNIPROT
LITERATURE
expressed in Escherichia coli C41(DE3) cells
-
expressed in Saccharomyces cerevisiae strain SM1188
-
expressed in Sf9 insect cells
-
expressed in Spodoptera frugiperda ovarian membranes
-
expression in Sf9 cells
-
expression of TrpE-STE14 methyl transferase fusion protein in Escherichia coli
-
His-Ste14p, which encodes Ste14p with a 10 x histidine tag followed by a triply iterated myc epitope repeat at the N terminus under the constitutive control of the phosphoglycerate kinase promoter, overexpressed in Saccharomyces cerevisiae
-
His10myc3-tagged Ste14p expressed in Saccharomyces cereVisiae
-
Icmt, expression in HEK-293 cells and Cos-1 cells
-
into the pCHH10m3N vector, overexpressed in Saccharomyces cerevisiae
-
overepression in tissue culture cells
-
the ICMT isozyme is encoded by the STE14A ICMT gene
the ICMT isozyme is encoded by the STE14B ICMT gene