2.1.1.1: nicotinamide N-methyltransferase

This is an abbreviated version!
For detailed information about nicotinamide N-methyltransferase, go to the full flat file.

Reaction

Synonyms

ANMT-1, B0303.2, methyltransferase, nicotinamide, nicotinamide N-methyl transferase, nicotinamide N-methyltransferase, NNMT

ECTree

     2 Transferases

         2.1 Transferring one-carbon groups

             2.1.1 Methyltransferases

                2.1.1.1 nicotinamide N-methyltransferase

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Results	in table
5	Activating Compound
30	AA Sequence
25	Application
1	CAS Registry Number
22	Cloned(Commentary)
15	Cofactor
8	Crystallization (Commentary)
555	Disease/ Diagnostics
17	Expression
38	General Information
2	General Stability
43	IC50 Value
61	Inhibitors
26	kcat/KM [mM/s]
6	Ki Value [mM]
47	KM Value [mM]
14	Localization
1	Metals/Ions
4	Molecular Weight [Da]
23	Natural Substrates/ Products (Substrates)
331	Organism
2	Pathway
58	PDB ID
10	pH Optimum
1	pH Range
14	Protein Variants
5	Purification (Commentary)
1	Reaction
1	Reaction Type
71	Reference
111	Source Tissue
16	Specific Activity [micromol/min/mg]
3	Storage Stability
61	Substrates and Products (Substrate)
3	Subunits
40	Synonyms
1	Systematic Name
9	Temperature Optimum [°C]
23	Turnover Number [1/s]

Substrates Products

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Substrates Products on EC 2.1.1.1 - nicotinamide N-methyltransferase

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SUBSTRATE

PRODUCT                       

REACTION DIAGRAM

ORGANISM

UNIPROT

COMMENTARY
(Substrate)

LITERATURE
(Substrate)

COMMENTARY
(Product)

LITERATURE
(Product)

Reversibility
r=reversible
ir=irreversible
?=not specified

L-methionine + nicotinamide

L-homocysteine + 1-methylnicotinamide

Rattus norvegicus

-

-

441251

-

-

?

nicotinamide + S-adenosyl-L-methionine

1-methylnicotinamide + S-adenosyl-L-homocysteine

2 entries

S-adenosyl-L-methionine + 1,2,3,4-tetrahydroisoquinoline

S-adenosyl-L-homocysteine + ?

Sus scrofa

-

-

441252

-

-

?

S-adenosyl-L-methionine + 2-methoxypyridine

S-adenosyl-L-homocysteine + 1-methyl-2-methoxypyridinium

Homo sapiens

P40261

-

758793

-

-

?

S-adenosyl-L-methionine + 2-methylpyridine

S-adenosyl-L-homocysteine + 1,2-dimethylpyridinium

Homo sapiens

P40261

-

758793

-

-

?

S-adenosyl-L-methionine + 3-acetylpyridine

S-adenosyl-L-homocysteine + ?

Sus scrofa

-

-

441252

-

-

?

S-adenosyl-L-methionine + 3-acetylpyridine

S-adenosyl-L-homocysteine + N-methyl-3-acetylpyridinium

Homo sapiens

P40261

-

758793

-

-

?

S-adenosyl-L-methionine + 4-methylnicotinamide

S-adenosyl-L-homocysteine + 1,4-dimethylnicotinamide

3 entries

S-adenosyl-L-methionine + 4-phenylpyridine

S-adenosyl-L-homocysteine + 1-methyl-4-phenylpyridine

Homo sapiens

P40261

poor substrate

756932

-

-

?

S-adenosyl-L-methionine + isoquinoline

S-adenosyl-L-homocysteine + ?

Sus scrofa

-

-

441252

-

-

?

S-adenosyl-L-methionine + isoquinoline

S-adenosyl-L-homocysteine + N-methylisoquinoline

Homo sapiens

P40261

-

758793

-

-

?

S-adenosyl-L-methionine + nicotinamide

S-adenosyl-L-homocysteine + 1-methylnicotinamide

16 entries

S-adenosyl-L-methionine + nicotinimidamide

S-adenosyl-L-homocysteine + N-methylnicotinimidamide

Homo sapiens

P40261

-

758793

-

-

?

S-adenosyl-L-methionine + norharman + H+

S-adenosyl-L-homocysteine + 2-N-methylnorharman

Homo sapiens

P40261

-

756000

-

-

?

S-adenosyl-L-methionine + quinoline

S-adenosyl-L-homocysteine + ?

Sus scrofa

-

-

441252

-

-

?

S-adenosyl-L-methionine + quinoline

S-adenosyl-L-homocysteine + N-methylquinoline

2 entries

S-adenosyl-L-methionine + quinoline 3-carboxamide

S-adenosyl-L-homocysteine + N-methylquinoline 3-carboxamide

Homo sapiens

P40261

-

758793

-

-

?

S-adenosyl-L-methionine + tetrahydroisoquinoline

S-adenosyl-L-homocysteine + N-methyltetrahydroisoquinoline

Homo sapiens

P40261

-

758793

-

-

?

S-adenosyl-L-methionine + thionicotinamide

S-adenosyl-L-homocysteine + 1-methylthionicotinamide

2 entries

additional information

?

-

7 entries

nicotinamide + S-adenosyl-L-methionine

1-methylnicotinamide + S-adenosyl-L-homocysteine

Homo sapiens

-

-

719027

-

-

?

nicotinamide + S-adenosyl-L-methionine

1-methylnicotinamide + S-adenosyl-L-homocysteine

Homo sapiens

P40261

-

718914

-

-

?

S-adenosyl-L-methionine + 4-methylnicotinamide

S-adenosyl-L-homocysteine + 1,4-dimethylnicotinamide

Homo sapiens

P40261

-

758793

-

-

?

S-adenosyl-L-methionine + 4-methylnicotinamide

S-adenosyl-L-homocysteine + 1,4-dimethylnicotinamide

Mus musculus

-

assay for fluorometric determination of enzyme activity

706094

-

-

?

S-adenosyl-L-methionine + 4-methylnicotinamide

S-adenosyl-L-homocysteine + 1,4-dimethylnicotinamide

Mus musculus C57/BL6J

-

assay for fluorometric determination of enzyme activity

706094

-

-

?

S-adenosyl-L-methionine + nicotinamide

S-adenosyl-L-homocysteine + 1-methylnicotinamide

Homo sapiens

-

-

441253, 441255, 701990, 733214, 733279, 733614, 733618, 733625, 733636, 734104, 734368

-

-

?

S-adenosyl-L-methionine + nicotinamide

S-adenosyl-L-homocysteine + 1-methylnicotinamide

Homo sapiens

P40261

-

756053, 757399

-

-

?

S-adenosyl-L-methionine + nicotinamide

S-adenosyl-L-homocysteine + 1-methylnicotinamide

Homo sapiens

-

-

757399

-

-

?

S-adenosyl-L-methionine + nicotinamide

S-adenosyl-L-homocysteine + 1-methylnicotinamide

Homo sapiens

P40261

-

758793

-

-

?

S-adenosyl-L-methionine + nicotinamide

S-adenosyl-L-homocysteine + 1-methylnicotinamide

Homo sapiens

P40261

NNMT as potential candidate for a tumor marker

687897

-

-

?

S-adenosyl-L-methionine + nicotinamide

S-adenosyl-L-homocysteine + 1-methylnicotinamide

Homo sapiens

P40261

NNMT gene polymorphism as potential marker for cardiovascular risk factors

690123

-

-

?

S-adenosyl-L-methionine + nicotinamide

S-adenosyl-L-homocysteine + 1-methylnicotinamide

Homo sapiens

P40261

NNMT potential as tumor marker

689036

-

-

?

S-adenosyl-L-methionine + nicotinamide

S-adenosyl-L-homocysteine + 1-methylnicotinamide

Homo sapiens

P40261

polymorphism in the nicotinamide N-methyltransferase (NNMT) gene as risk factor for complex congenital heart defects (CHDs)

686485

-

-

?

S-adenosyl-L-methionine + nicotinamide

S-adenosyl-L-homocysteine + 1-methylnicotinamide

Macaca mulatta

F7ERX8

-

755958

-

-

?

S-adenosyl-L-methionine + nicotinamide

S-adenosyl-L-homocysteine + 1-methylnicotinamide

Mus musculus

-

-

441258, 701990, 706094, 733737, 734368, 734757

-

-

?

S-adenosyl-L-methionine + nicotinamide

S-adenosyl-L-homocysteine + 1-methylnicotinamide

Mus musculus

O55239

-

755958

-

-

?

S-adenosyl-L-methionine + nicotinamide

S-adenosyl-L-homocysteine + 1-methylnicotinamide

Mus musculus C57/BL6J

-

-

441258, 706094

-

-

?

S-adenosyl-L-methionine + nicotinamide

S-adenosyl-L-homocysteine + 1-methylnicotinamide

Mus musculus C57Bl6/J

-

-

734757

-

-

?

S-adenosyl-L-methionine + nicotinamide

S-adenosyl-L-homocysteine + 1-methylnicotinamide

Oryctolagus cuniculus

-

-

734368

-

-

?

S-adenosyl-L-methionine + nicotinamide

S-adenosyl-L-homocysteine + 1-methylnicotinamide

Rattus norvegicus

-

L-methionine + nicotinamide

441251

-

-

?

S-adenosyl-L-methionine + nicotinamide

S-adenosyl-L-homocysteine + 1-methylnicotinamide

Sus scrofa

-

-

441252

-

-

?

S-adenosyl-L-methionine + quinoline

S-adenosyl-L-homocysteine + N-methylquinoline

Homo sapiens

P40261

-

756053, 758793

-

-

?

S-adenosyl-L-methionine + quinoline

S-adenosyl-L-homocysteine + N-methylquinoline

Homo sapiens

-

-

758793

-

-

?

S-adenosyl-L-methionine + thionicotinamide

S-adenosyl-L-homocysteine + 1-methylthionicotinamide

Homo sapiens

P40261

-

758793

-

-

?

S-adenosyl-L-methionine + thionicotinamide

S-adenosyl-L-homocysteine + 1-methylthionicotinamide

Sus scrofa

-

-

441252

-

-

?

additional information

?

-

Homo sapiens

-

NNMT catalyzes the N-methylation of nicotinamide and other structural analogs, and is involved in the biotransformation of many drugs and xenobiotic compounds

704775

-

-

?

additional information

?

-

Homo sapiens

-

development and evaluation of a HPLC-UV method for measuring nicotinamide N-methyltransferase activity in biological samples, overview

734368

-

-

?

additional information

?

-

Homo sapiens

P40261

NNMT uses a rapid equilibrium ordered mechanism, where NNMT first binds S-adenosyl-L-methionine, which is followed by nicotinamide. Methyl transfer occurs, and methylated nicotinamide and S-adenosylhomocysteine are released consecutively

756053

-

-

-

additional information

?

-

Homo sapiens

-

NNMT uses a rapid equilibrium ordered mechanism, where NNMT first binds S-adenosyl-L-methionine, which is followed by nicotinamide. Methyl transfer occurs, and methylated nicotinamide and S-adenosylhomocysteine are released consecutively

756053

-

-

-

additional information

?

-

Mus musculus

-

development and evaluation of a HPLC-UV method for measuring nicotinamide N-methyltransferase activity in biological samples, overview

734368

-

-

?

additional information

?

-

Oryctolagus cuniculus

-

development and evaluation of a HPLC-UV method for measuring nicotinamide N-methyltransferase activity in biological samples, overview

734368

-

-

?

additional information

?

-

Sus scrofa

-

enzyme may function in detoxificating of numerous alkaloids

441252

-

-

?