2.1.1.1: nicotinamide N-methyltransferase
This is an abbreviated version!
For detailed information about nicotinamide N-methyltransferase, go to the full flat file.
Reaction
Synonyms
ANMT-1, B0303.2, methyltransferase, nicotinamide, nicotinamide N-methyl transferase, nicotinamide N-methyltransferase, NNMT
ECTree
2.1.1.1 nicotinamide N-methyltransferaseAdvanced search results
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results (Source Tissue
Source Tissue on EC 2.1.1.1 - nicotinamide N-methyltransferase
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SOURCE TISSUE 
ORGANISM
UNIPROT
COMMENTARY 
LITERATURE
SOURCE
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elevated enzyme activity during cell differentiation in adipose tissue
NNMT expression increased on stimulation of the cells with interleukin 6, NNMT promoter activity dependent on the activation of Stat3
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the cells show enzyme overexpression compared to both tumor-adjacent and surrounding tissue
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sera from 24 healthy individuals, from 113 non-small cell lung cancer patients undergoing surgery, and from 50 nonneoplastic lung disease patients with chronic obstructive pulmonary disease. Serum levels of NNMT are signficantly higher in lung cancer patients, overview
additional information
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the enzyme is robustly expressed in neurones in all regions of the brain
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the enzyme is significantly overexpressed in a variety of diseases ranging from cancer to hepatic cirrhosis
colon cancer cells with high and constitutive expression of NNMT
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high enzyme activity. Enzyme upregulation in vascular inflammation and atherosclerosis, overview
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hepatic expression of Nnmt is highly variable and correlates with multiple metabolic parameters in humans
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high enzyme activity. Enzyme upregulation in vascular inflammation and atherosclerosis, overview
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hepatic expression of Nnmt is highly variable and correlates with multiple metabolic parameters in humans
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serum levels of NNMT are signficantly higher in lung cancer patients, overview
breast cancer cells with high and constitutive expression of NNMT
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sharp increase in nicotinamide N-methyltransferase (NNMT) mRNA level in miR-1291-expressing PANC-1 cells at elevated N-methylnicotinamide levels
colon cancer cells, NNMT expression increased on stimulation of the cells with interleukin 6
additional information
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high enzyme activity in papillary carcinoma cell lines, no or low activity in normal thyroid tissue, thyroid primary cultures, anaplastic cancer cells, and medullary cancer cells
additional information
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enzyme expression levels in healthy oral mucosa and in oral squamous cell carcinomas, overview
additional information
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nicotinamide N-methyltransferase is overexpressed in several malignancies, including colorectal cancer cells. No constitutive expresion of the enzyme in colorectal cancer cells line SW480
additional information
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no activity in the SH-SY5Y human neuroblastoma cell line and in N27 cells
additional information
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no enzyme activity in SH-SY5Y human neuroblastoma cells
additional information
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SH-SY5Y human neuroblastoma cells have no endogenous expression of enzyme NNMT
additional information
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the enzyme is overexpressed in many human cancers and is associated with poor prognosis
