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2.1.1.1: nicotinamide N-methyltransferase

This is an abbreviated version!
For detailed information about nicotinamide N-methyltransferase, go to the full flat file.

Reaction

S-adenosyl-L-methionine
+
nicotinamide
 +
H+
=
S-adenosyl-L-homocysteine
 +
1-methylnicotinamide

Synonyms

ANMT-1, B0303.2, methyltransferase, nicotinamide, nicotinamide N-methyl transferase, nicotinamide N-methyltransferase, NNMT

ECTree

     2 Transferases
         2.1 Transferring one-carbon groups
             2.1.1 Methyltransferases
                2.1.1.1 nicotinamide N-methyltransferase

Cloned

Cloned on EC 2.1.1.1 - nicotinamide N-methyltransferase

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CLONED (Commentary)
ORGANISM
UNIPROT
LITERATURE
expressed in Escherichia coli BL21(DE3)
expressed in Escherichia coli, NNMT promoter region, promoter-luciferase reporter construct generated, pGL2 vector
expressed in HEK293 cells
-
expression in Escherichia coli
gene NNMT, expression fo the GST-tagged enzyme in Escherichia coli strain JM109
-
gene NNMT, expression profiling in bladder cancer cell lines, overview
-
gene NNMT, genotyping, no allelic or genotypic association of the genetic variations of NNMT with spina bifida in the population of white non-hispanic individuals from California
-
gene NNMT, quantitative enzyme expression anaysis in 124 nasopharyngeal carcinoma samples, analysis of associations between NNMT and pAktSer473 expression and other important clinicopathologic variables, overview
-
overexpressed in SH-SY5Y cell line
-
quantitative real-time PCR enzyme expression analysis in non-smalll cell lung cancer samples
-
recombinant ectopic expression of NNMT in enzyme-deficient SH-SY5Y human neuroblastoma cells increasing adenosine triphosphate synthesis and complex I activity
-
recombinant enzyme overexpression in PANC-1 cells, quantitative real-time PCR enzyme expression analysis
-
recombinant overexpression of enzyme NNMT in colorectal cancer cells line SW480 which lacks constitutive NNMT expression, quantitative real-time PCR analysis
-
recombinant stable expression of NNMT-V5 in SH-SY5Y cells increases complex I activity via sirtuin 3
-
stable recombinant expression of enzyme NNMT in the SH-SY5Y human neuroblastoma cell line, which has no endogenous enzyme expression, at levels of activity comparable with that in Parkinson's disease brain, recombinant expression of enzyme NNMT in SH-SY5Y human neuroblastoma and N27 rat mesencephalic dopaminergic neurones increases neurite branching, synaptophysin expression and dopamine accumulation and release. Recombinant NNMT-V5 expression in SH-SY5Y cells changes cellular morphology and increases dopamine uptake and release. Transient expression of enzyme NNMT in N27 cells
-