1.8.99.B1: protein-disulfide reductase (acceptor)
This is an abbreviated version!
For detailed information about protein-disulfide reductase (acceptor), go to the full flat file.
Word Map on EC 1.8.99.B1
Reaction
Synonyms
AaPDO, ApPDO, disulfide bond-forming enzyme, glutaredoxin related protein, PDO, PfPDO, protein disulfide oxidoreductase, SSO0192, SSO10610, Sso1120, SsPDO
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Engineering on EC 1.8.99.B1 - protein-disulfide reductase (acceptor)
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PROTEIN VARIANTS 
ORGANISM
UNIPROT
COMMENTARY 
LITERATURE
C148S
mutant enzyme exhibits a lower activity compared to wild-type enzyme
C146S
not active in the insulin reductase assay, oxidation of the dithiol peptide NRCSQGSCWN is reduced
C35S
active in the insulin reductase assay, oxidation of the dithiol peptide NRCSQGSCWN is comparable to wild-type enzyme
C35S/C146S
not active in the insulin reductase assay, no oxidation of the dithiol peptide NRCSQGSCWN
C155S/C158S
with insulin as substrate the enzyme is completely inactive
C173S/C178S
with insulin as substrate the enzyme shows lower activity than wild-type enzyme
C41S/C44S
with insulin as substrate the enzyme shows lower activity than wild-type enzyme
C155S/C158S
-
with insulin as substrate the enzyme is completely inactive
-
C173S/C178S
-
with insulin as substrate the enzyme shows lower activity than wild-type enzyme
-
C41S/C44S
-
with insulin as substrate the enzyme shows lower activity than wild-type enzyme
-
