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1.8.5.1: glutathione dehydrogenase (ascorbate)

This is an abbreviated version!
For detailed information about glutathione dehydrogenase (ascorbate), go to the full flat file.

Word Map on EC 1.8.5.1

Reaction

2 glutathione +

dehydroascorbate
=
glutathione disulfide
+
ascorbate

Synonyms

At1g19570, At1g75270, At5g16710, AtDHAR, AtDHAR1, AtDHAR2, AtDHAR3, CrDHAR1, DasA reductase, dehydroascorbate reductase, dehydroascorbate reductase 2, dehydroascorbic acid reductase, dehydroascorbic reductase, dehydrogenase, glutathione (ascorbate), DHA reductase, DHA-R, DHAR, DHAR1, DHAR2, DHAR3, DHAR3a, DHAR4, DHAR5, dioscorin, GDOR, glutathione dehydroascorbate reductase, glutathione-dependent dehydroascorate reductase, glutathione:dehydroascorbic acid oxidoreductase, GRX1, GRX2, GSH-DHAR, GSH:DHA-oxidoreductase, GSTO, GSTO1, GSTO1-1, GSTO2, GSTO2-2, LcDHAR, metallothionein-1, metallothionein-2, More, MT-I, MT-II, nlGSTO, OsDHAR, OsDHAR1, PbDHAR, PgDHAR1, PtrDHAR1, PtrDHAR2, PtrDHAR3A, PtrDHAR3B, SPD1

ECTree

     1 Oxidoreductases
         1.8 Acting on a sulfur group of donors
             1.8.5 With a quinone or similar compound as acceptor
                1.8.5.1 glutathione dehydrogenase (ascorbate)

Inhibitors

Inhibitors on EC 1.8.5.1 - glutathione dehydrogenase (ascorbate)

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INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
beauvericin
BEA, an ionophore, that induces oxidative stress, acts as an antimicrobial and as an enzyme inhibitor. Its cytotoxicity is mostly due to the selective ionophore (channel-forming) activity on biological membranes, which allows a flux of cations, particularly Ca2+, into the cell
Ca2+
-
5 mM, 34% loss of activity
Cd2+
-
5 mM CdCl2, complete loss of activity
Cyanate
-
500 mM, 15% inhibition
dehydroascorbate
-
at high concentrations
diazinon
about 40% inhibition
Fe2+
-
0.1 mM FeSO4, 34% loss of activity
Fe3+
-
1 mM, complete inhibition
H2O2
in vitro oxidation of the recombinant CrDHAR1 in the presence of 1 mM H2O2 has minor effects on the Km for the substrates but significantly reduces the kcat. The enzyme's activity and its mRNA abundance in the Chlamydomonas reinhardtii cells are increased by treatment with 0.2-1.0 mM H2O2 but decreased when H2O2 is over 1.5 mM
HgCl2
imidazole
-
1 mM, 14% loss of activity
iodoacetamide
-
-
iodoacetic acid
Mersalyl
-
-
Mn2+
-
5 mM MnSO4, 82% loss of activity
p-chloromercuriphenylsulfonate
-
-
p-hydroxymercuribenzoate
-
1 mM, 70% inhibition
permethrin
about 40% inhibition
Sodium azide
-
1 mM, 32% loss of activity
additional information
-