1.8.4.9: adenylyl-sulfate reductase (glutathione)

This is an abbreviated version!
For detailed information about adenylyl-sulfate reductase (glutathione), go to the full flat file.

Reaction

Synonyms

3'-phosphoadenosine-5'-phosphosulfate reductase homolog 19, 3'-phosphoadenosine-5'-phosphosulfate reductase homolog 26, 3'-phosphoadenosine-5'-phosphosulfate reductase homolog 43, 5'-adenylylsulfate reductase, 5-adenosinephosphosulphate reductase, adenosine 5'-phosphosulfate reductase, adenosine 5-phosphosulfate reductase, adenosine-5'-phosphosulfate reductase, adenosine-5'-phosphosulphate reductase, APR, APR1, APR1p, APR2, APS reductase, At1g62180, AtAPR1, CysH, EC 1.8.99.2, EiAPR, More, PAPS reductase homolog 19, PAPS reductase homolog 26, PAPS reductase homolog 43, plant-type 5'-adenylylsulfate reductase, PpAPR-B, Prh-19, Prh-26, Prh-43

ECTree

     1 Oxidoreductases

         1.8 Acting on a sulfur group of donors

             1.8.4 With a disulfide as acceptor

                1.8.4.9 adenylyl-sulfate reductase (glutathione)

Advanced search results

Do not include text mining results

Include results (more...)

Include results (more...)

Results	in table
6	Activating Compound
17	AA Sequence
2	Application
1	CAS Registry Number
16	Cloned(Commentary)
13	Cofactor
3	Crystallization (Commentary)
3	Expression
13	General Information
2	General Stability
11	Inhibitors
4	Ki Value [mM]
25	KM Value [mM]
9	Localization
11	Metals/Ions
20	Molecular Weight [Da]
15	Natural Substrates/ Products (Substrates)
59	Organism
7	Pathway
1	PDB ID
6	pH Optimum
1	pH Range
7	Protein Variants
9	Purification (Commentary)
2	Reaction
3	Reaction Type
34	Reference
13	Source Tissue
23	Specific Activity [micromol/min/mg]
4	Storage Stability
71	Substrates and Products (Substrate)
9	Subunits
56	Synonyms
1	Systematic Name
4	Temperature Optimum [°C]
1	Temperature Range [°C]
1	Temperature Stability [°C]
11	Turnover Number [1/s]

Substrates Products

print visible entries

print all entries

Go back to the abbreviated version
of the Enzyme Summary Page.

Substrates Products on EC 1.8.4.9 - adenylyl-sulfate reductase (glutathione)

Please wait a moment until all data is loaded. This message will disappear when all data is loaded.

top print hide show all columns Go to Substrate/Product Search

Please wait a moment until the data is sorted. This message will disappear when the data is sorted.

SUBSTRATE

PRODUCT                       

REACTION DIAGRAM

ORGANISM

UNIPROT

COMMENTARY
(Substrate)

LITERATURE
(Substrate)

COMMENTARY
(Product)

LITERATURE
(Product)

Reversibility
r=reversible
ir=irreversible
?=not specified

3'-phosphoadenosine 5'-phosphosulfate + dithioerythritol

?

Physcomitrium patens

-

-

687585

-

-

?

3'-phosphoadenosine 5'-phosphosulfate + glutathione

adenosine 3',5'-diphosphate + sulfite + oxidized glutathione

Physcomitrium patens

-

-

687585

-

-

?

3'-phosphoadenosine-5'-phosphosulfate + glutathione

adenosine 3',5'-bisphosphate + sulfite + oxidized glutathione

Mycobacterium tuberculosis

-

-

667703

-

-

?

3'-phosphoadenosine-5'-phosphosulfate + glutathione

adenosine 3',5'-diphosphate + sulfite + oxidized glutathione

12 entries

5'-adenylyl sulfate + glutathione

AMP + sulfite + glutathione disulfide

7 entries

5'-adenylyl sulfate + thioredoxin

AMP + sulfite + thioredoxin disulfide

Pseudomonas aeruginosa

-

recombinant enzyme in transgenic Arabidopsis thaliana plants

660168

-

-

?

5'-adenylylsulfate + dithioerythritol

adenosine 5'-monophosphate + sulfite + oxidized dithioerythritol

2 entries

5'-adenylylsulfate + dithiothreitol

adenosine 5'-monophosphate + sulfite + oxidized dithiothreitol

4 entries

5'-adenylylsulfate + glutathione

adenosine monophosphate + sulfite + oxidized glutathione

13 entries

5'-adenylylsulfate + glutathione + glutathione

adenosine monophosphate + sulfite + oxidized glutathione

3 entries

adenosine 5'-phosphosulfate + glutathione

?

Physcomitrium patens

-

PpAPR-B is much more active with adenosine 5'-phosphosulfate as a substrate than with 3'-phosphoadenosine 5'-phosphosulfate

687585

-

-

?

adenylyl sulfate + 2 glutathione

AMP + sulfite + glutathione disulfide

4 entries

adenylyl sulfate + DTT

?

Physcomitrium patens

-

-

687585, 694695

-

-

?

adenylyl sulfate + glutathione

AMP + sulfite + glutathione disulfide

4 entries

AMP + sulfite + glutathione disulfide

adenylyl sulfate + 2 glutathione

Arabidopsis thaliana

P92979

-

763921

-

-

?

cystine + glutathione

cysteine + glutathione disulfide

Arabidopsis thaliana

P92979

catalyzed by the holoenzyme APR1p and the C-domain

660399

-

-

?

dehydroascorbate + glutathione

ascorbate + glutathione disulfide

Arabidopsis thaliana

P92979

catalyzed by the holoenzyme APR1p and the C-domain

660399

-

-

?

hydroxyethyldisulfide + glutathione

?

Arabidopsis thaliana

P92979

catalyzed by the holoenzyme APR1p and the C-domain

660399

-

-

?

insulin disulfide + glutathione

insulin + glutathione disulfide

Arabidopsis thaliana

P92979

catalyzed by the C-domain, not by the holoenzyme APR1p or the R-domain

660399

-

-

?

oxidized ribonucleotide reductase + glutathione

reduced ribonucleotide reductase + glutathione disulfide

Arabidopsis thaliana

P92979

catalyzed by the C-domain, not by the holoenzyme APR1p or the R-domain

660399

-

-

?

additional information

?

-

7 entries

3'-phosphoadenosine-5'-phosphosulfate + glutathione

adenosine 3',5'-diphosphate + sulfite + oxidized glutathione

Arabidopsis thaliana

-

-

288641, 288643

-

-

?

3'-phosphoadenosine-5'-phosphosulfate + glutathione

adenosine 3',5'-diphosphate + sulfite + oxidized glutathione

Arabidopsis thaliana

-

50fold lower activity than with 5'-adenylylsulfate

288640

-

-

?

3'-phosphoadenosine-5'-phosphosulfate + glutathione

adenosine 3',5'-diphosphate + sulfite + oxidized glutathione

Brassica juncea

-

no activity with 3'-phosphoadenosine-5'-phosphosulfate

288643

-

-

?

3'-phosphoadenosine-5'-phosphosulfate + glutathione

adenosine 3',5'-diphosphate + sulfite + oxidized glutathione

Conticribra weissflogii

-

no activity with 3'-phosphoadenosine-5'-phosphosulfate

288643

-

-

?

3'-phosphoadenosine-5'-phosphosulfate + glutathione

adenosine 3',5'-diphosphate + sulfite + oxidized glutathione

Dunaliella salina

-

no activity with 3'-phosphoadenosine-5'-phosphosulfate

288643

-

-

?

3'-phosphoadenosine-5'-phosphosulfate + glutathione

adenosine 3',5'-diphosphate + sulfite + oxidized glutathione

Emiliania huxleyi

-

no activity with 3'-phosphoadenosine-5'-phosphosulfate

288643

-

-

?

3'-phosphoadenosine-5'-phosphosulfate + glutathione

adenosine 3',5'-diphosphate + sulfite + oxidized glutathione

Heterocapsa triquetra

-

no activity with 3'-phosphoadenosine-5'-phosphosulfate

288643

-

-

?

3'-phosphoadenosine-5'-phosphosulfate + glutathione

adenosine 3',5'-diphosphate + sulfite + oxidized glutathione

Isochrysis galbana

-

no activity with 3'-phosphoadenosine-5'-phosphosulfate

288643

-

-

?

3'-phosphoadenosine-5'-phosphosulfate + glutathione

adenosine 3',5'-diphosphate + sulfite + oxidized glutathione

Lemna minor

-

no activity with 3'-phosphoadenosine-5'-phosphosulfate

288644

-

-

?

3'-phosphoadenosine-5'-phosphosulfate + glutathione

adenosine 3',5'-diphosphate + sulfite + oxidized glutathione

Tetraselmis sp.

-

no activity with 3'-phosphoadenosine-5'-phosphosulfate

288643

-

-

?

3'-phosphoadenosine-5'-phosphosulfate + glutathione

adenosine 3',5'-diphosphate + sulfite + oxidized glutathione

Thalassiosira oceanica

-

no activity with 3'-phosphoadenosine-5'-phosphosulfate

288643

-

-

?

3'-phosphoadenosine-5'-phosphosulfate + glutathione

adenosine 3',5'-diphosphate + sulfite + oxidized glutathione

Ulva intestinalis

-

no activity with 3'-phosphoadenosine-5'-phosphosulfate

288643

-

-

?

5'-adenylyl sulfate + glutathione

AMP + sulfite + glutathione disulfide

Arabidopsis thaliana

-

-

660168

-

-

?

5'-adenylyl sulfate + glutathione

AMP + sulfite + glutathione disulfide

Arabidopsis thaliana

-

enzyme is involved in reductive sulfate assimilation, pathway overview

660168

-

-

?

5'-adenylyl sulfate + glutathione

AMP + sulfite + glutathione disulfide

Arabidopsis thaliana

P92979

catalyzed by the holoenzyme APR1p, not by the C-domain

660399

-

-

?

5'-adenylyl sulfate + glutathione

AMP + sulfite + glutathione disulfide

Glycine max

-

-

689431

-

-

?

5'-adenylyl sulfate + glutathione

AMP + sulfite + glutathione disulfide

Pseudomonas aeruginosa

-

-

660168

-

-

?

5'-adenylyl sulfate + glutathione

AMP + sulfite + glutathione disulfide

Pseudomonas aeruginosa

-

enzyme is involved in reductive sulfate assimilation, pathway overview

660168

-

-

?

5'-adenylyl sulfate + glutathione

AMP + sulfite + glutathione disulfide

Ulva intestinalis

-

-

667746

-

-

?

5'-adenylylsulfate + dithioerythritol

adenosine 5'-monophosphate + sulfite + oxidized dithioerythritol

Catharanthus roseus

-

-

288642

-

-

?

5'-adenylylsulfate + dithioerythritol

adenosine 5'-monophosphate + sulfite + oxidized dithioerythritol

Lemna minor

-

-

288644

-

-

?

5'-adenylylsulfate + dithiothreitol

adenosine 5'-monophosphate + sulfite + oxidized dithiothreitol

Arabidopsis thaliana

-

-

288640

-

-

?

5'-adenylylsulfate + dithiothreitol

adenosine 5'-monophosphate + sulfite + oxidized dithiothreitol

Archaeoglobus fulgidus

-

-

667717

-

-

ir

5'-adenylylsulfate + dithiothreitol

adenosine 5'-monophosphate + sulfite + oxidized dithiothreitol

Catharanthus roseus

-

-

288642

-

-

?

5'-adenylylsulfate + dithiothreitol

adenosine 5'-monophosphate + sulfite + oxidized dithiothreitol

Glycine max

-

-

689431

-

-

?

5'-adenylylsulfate + glutathione

adenosine monophosphate + sulfite + oxidized glutathione

Arabidopsis thaliana

-

-

288640, 288641, 288643

-

-

?

5'-adenylylsulfate + glutathione

adenosine monophosphate + sulfite + oxidized glutathione

bacteria endosymbiont of Lucinoma aff. kazani

Q0KG00

-

668650

-

-

?

5'-adenylylsulfate + glutathione

adenosine monophosphate + sulfite + oxidized glutathione

Brassica juncea

-

-

288643

-

-

?

5'-adenylylsulfate + glutathione

adenosine monophosphate + sulfite + oxidized glutathione

Catharanthus roseus

-

-

288642

-

-

?

5'-adenylylsulfate + glutathione

adenosine monophosphate + sulfite + oxidized glutathione

Conticribra weissflogii

-

-

288643

-

-

?

5'-adenylylsulfate + glutathione

adenosine monophosphate + sulfite + oxidized glutathione

Dunaliella salina

-

-

288643

-

-

?

5'-adenylylsulfate + glutathione

adenosine monophosphate + sulfite + oxidized glutathione

Emiliania huxleyi

-

-

288643

-

-

?

5'-adenylylsulfate + glutathione

adenosine monophosphate + sulfite + oxidized glutathione

Heterocapsa triquetra

-

-

288643

-

-

?

5'-adenylylsulfate + glutathione

adenosine monophosphate + sulfite + oxidized glutathione

Isochrysis galbana

-

-

288643

-

-

?

5'-adenylylsulfate + glutathione

adenosine monophosphate + sulfite + oxidized glutathione

Lemna minor

-

-

288644

-

-

?

5'-adenylylsulfate + glutathione

adenosine monophosphate + sulfite + oxidized glutathione

Tetraselmis sp.

-

-

288643

-

-

?

5'-adenylylsulfate + glutathione

adenosine monophosphate + sulfite + oxidized glutathione

Thalassiosira oceanica

-

-

288643

-

-

?

5'-adenylylsulfate + glutathione

adenosine monophosphate + sulfite + oxidized glutathione

Ulva intestinalis

-

-

288643

-

-

?

5'-adenylylsulfate + glutathione + glutathione

adenosine monophosphate + sulfite + oxidized glutathione

Mycobacterium tuberculosis

-

-

670319

-

-

?

5'-adenylylsulfate + glutathione + glutathione

adenosine monophosphate + sulfite + oxidized glutathione

Mycobacterium tuberculosis

-

-

667703

-

-

r

5'-adenylylsulfate + glutathione + glutathione

adenosine monophosphate + sulfite + oxidized glutathione

Pseudomonas aeruginosa

-

-

669891

-

-

r

adenylyl sulfate + 2 glutathione

AMP + sulfite + glutathione disulfide

Arabidopsis thaliana

-

-

765161

-

-

?

adenylyl sulfate + 2 glutathione

AMP + sulfite + glutathione disulfide

Arabidopsis thaliana

P92981

-

764564

-

-

?

adenylyl sulfate + 2 glutathione

AMP + sulfite + glutathione disulfide

Arabidopsis thaliana Col-0

-

-

765161

-

-

?

adenylyl sulfate + 2 glutathione

AMP + sulfite + glutathione disulfide

Arabidopsis thaliana Col-0

P92981

-

764564

-

-

?

adenylyl sulfate + glutathione

AMP + sulfite + glutathione disulfide

Arabidopsis thaliana

-

-

694712

-

-

?

adenylyl sulfate + glutathione

AMP + sulfite + glutathione disulfide

Physcomitrium patens

-

-

694695

-

-

?

adenylyl sulfate + glutathione

AMP + sulfite + glutathione disulfide

Physcomitrium patens

-

sulfate assimilation pathway in Physcomitrella patens, overview

687585

-

-

?

adenylyl sulfate + glutathione

AMP + sulfite + glutathione disulfide

Physcomitrium patens

-

substrate binding structure, modelling, overview

687585

-

-

?

additional information

?

-

Arabidopsis thaliana

P92979

enzyme is involved in sulfate assimilation

660399

-

-

?

additional information

?

-

Arabidopsis thaliana

-

enzyme is involved in sulfate assimilation

660399

-

-

?

additional information

?

-

Arabidopsis thaliana

-

APR is the key enzyme of sulfate assimilation, extensive posttranscriptional regulation of plant APR, e.g. by salt stress, sulfate assimilation pathway is controlled by a complex network of multiple signals on different regulatory levels, overview

694712

-

-

?

additional information

?

-

Arabidopsis thaliana

P92979

GSH is docked into the AtAPR1 redox domain active site by manual docking, superimposing the structures of glutaredoxin bound with GSH on that of the AtAPR1 redox domain. The structure of cGrx1 complexed with GSH (PDB code 4TR1) is used as a template. Interaction between GSH and the AtAPR1 redox domain is analyzed, binding structure analysis, overview

763921

-

-

-

additional information

?

-

Physcomitrium patens

-

no activity with thioredoxin

687585

-

-

?

additional information

?

-

Physcomitrium patens

-

the moss Physcomitrella patens is unique among these organisms in possessing orthologs of both APR and PAPR, EC 1.8.4.8, genes

687585

-

-

?

additional information

?

-

Zea mays

-

enzyme is involved in sulfate assimilation, influence of chilling stress on the intercellular distribution of assimilatory sulfate reduction and thiols, overview

660113

-

-

?