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1.8.4.7: enzyme-thiol transhydrogenase (glutathione-disulfide)

This is an abbreviated version!
For detailed information about enzyme-thiol transhydrogenase (glutathione-disulfide), go to the full flat file.

Word Map on EC 1.8.4.7

Reaction

[Xanthine dehydrogenase]
+
glutathione disulfide
=
[xanthine oxidase]
+ 2 glutathione

Synonyms

DnaJ, enzyme-thiol transhydrogenase (oxidized glutathione), glutathione-dependent thiol:disulfide oxidoreductase, thiol-disulfide oxidoreductase, thiol:disulfide oxidoreductase, thiol:disulphide oxidoreductase, YkuV, [xanthine-dehydrogenase]:oxidized-glutathione S-oxidoreductase

ECTree

     1 Oxidoreductases
         1.8 Acting on a sulfur group of donors
             1.8.4 With a disulfide as acceptor
                1.8.4.7 enzyme-thiol transhydrogenase (glutathione-disulfide)

Systematic Name

Systematic Name on EC 1.8.4.7 - enzyme-thiol transhydrogenase (glutathione-disulfide)

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SYSTEMATIC NAME
IUBMB Comments
[xanthine-dehydrogenase]:glutathione-disulfide S-oxidoreductase
Converts EC 1.17.1.4 xanthine dehydrogenase into EC 1.17.3.2 xanthine oxidase in the presence of glutathione disulfide; also reduces the disulfide bond of ricin. Not inhibited by Cu2+ or thiol reagents.