1.8.4.2: protein-disulfide reductase (glutathione)
This is an abbreviated version!
For detailed information about protein-disulfide reductase (glutathione), go to the full flat file.
Reaction
2 glutathione
+
=
+
Synonyms
BbdC, BdbD, C1orf31, CatA protein, ccdA associated thiol-disulfide oxidoreductase, COA6, DcbA, desulfothioredoxin, DIP1880, disulfide bond-forming thiol-disulfide oxidoreductase, disulphide interchange enzyme, DsbA, DsbA1, DsbA2, Dtrx, ERp57, GIT, glutathione-insulin transhydrogenase, glutathione-protein disulfide oxidoreductase, GRX1, GRX2, GRX3, GRX5, GRX6, GrxS12, GSH-dependent protein disulfide oxidoreductase, GSH-insulin transhydrogenase, HP_0231, insulin reductase, mcrophage migration inhibitory factor-2, MdbA, MdbACm, membrane-bound thiol-disulfide oxidoreductase, Mif-2, More, protein disulfide reductase (glutathione), protein disulfide transhydrogenase, protein-disulfide interchange enzyme, protein-disulfide isomerase/oxidoreductase, RCAP_rcc01743, reductase, protein disulfide (glutathione), ResA, SdbA, SGO_2006, SpyM18_2037, StoA, Streptococcus disulfide bond protein A, TDOR, thiol disulfide oxidoreductase, thiol-disulfide oxidoreductase, thiol-protein disulphide oxidoreductase, thiol:disulfide oxidoreductase, thiol:protein-disulfide oxidoreductase, WhiB1, WhiB1/Rv3219, YkuV, YMR244C-A
ECTree
Inhibitors
Inhibitors on EC 1.8.4.2 - protein-disulfide reductase (glutathione)
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1,3-Bis(2-chloroethyl)-1-nitrosourea
cysteine
-
at high concentration
GSSG
-
product inhibition
guanidinium hydrochloride
-
destroys zinc finger thiols of DnaJ protein
Insulin analogs
-
competitive inhibition of insulin degradation, overview
-
N-acetyl-L-tyrosine ethyl ester
-
-
N-ethylmaleimide
-
treatment with thiol prior to incubation with GSH and substrate: no inhibition, preincubation with GSH and thiol reagent: inhibition
S-Sulfonated A-chain or B-chain of insulin
-
product inhibition
-
Scrambled forms of ribonuclease and lysozyme
-
inhibition of insulin degradation
-
Triton X-100
-
inhibitory for the solubilized enzyme
1,3-Bis(2-chloroethyl)-1-nitrosourea
-
-
1,3-Bis(2-chloroethyl)-1-nitrosourea
-
-
Aprotinin
-
-
arsenite
-
-
bacitracin
-
-
Ca2+
-
slight
Cu2+
-
-
deoxycholate
-
-
deoxycholate
-
inhibitory for the solubilized enzyme
EDTA
-
oxidation activity
EDTA
-
50% inhibition at 5 mM
Hg2+
-
-
iodoacetamide
-
treatment with thiol prior to incubation with GSH and substrate: no inhibition, preincubation with GSH and thiol reagent: inhibition
iodoacetate
-
treatment with thiol prior to incubation with GSH and substrate: no inhibition, preincubation with GSH and thiol reagent: inhibition
lysolecithin
-
-
lysophosphatidylcholine
-
-
lysophosphatidylcholine
-
-
Mg2+
-
slight inhibition
Ni2+
-
slight
Phenylarsine oxide
-
-
Phenylarsine oxide
-
complete inhibition at 1 mM
phosphatidic acid
-
-
Se2+
-
-
Zn2+
-
-
additional information
-
overview
-
additional information
-
enzyme preincubated with toxins, e.g. ricin and Viscum album lectin, enhances their inhibitory effects against protein synthesis
-
additional information
-
overview product inhibition
-
additional information
-
carboxylation of thiol groups abolish reduction activity
-
additional information
-
overview
-
additional information
-
overview
-
additional information
-
overview
-
additional information
-
enzyme preincubated with toxins, e.g. ricin and Viscum album lectin, enhances their inhibitory effects against protein synthesis
-