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1.8.4.13: L-methionine (S)-S-oxide reductase

This is an abbreviated version!
For detailed information about L-methionine (S)-S-oxide reductase, go to the full flat file.

Reaction

L-methionine
+
thioredoxin disulfide
+
H2O
=
L-methionine (S)-S-oxide
+
thioredoxin

Synonyms

EC 1.8.4.5, free-methionine-R-sulfoxide reductase, fRMsr, fSMsr, methionine sulfoxide reductase

ECTree

     1 Oxidoreductases
         1.8 Acting on a sulfur group of donors
             1.8.4 With a disulfide as acceptor
                1.8.4.13 L-methionine (S)-S-oxide reductase

Natural Substrates Products

Natural Substrates Products on EC 1.8.4.13 - L-methionine (S)-S-oxide reductase

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NATURAL SUBSTRATE
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
L-(-)-methionine S-oxide + NADPH
L-methionine + NADP+ + H2O
show the reaction diagram
-
the enzyme is specific for the L-(-)-stereoisomer
-
-
ir
L-methionine (S)-sulfoxide + NADPH + H+
L-methionine + NADP+ + H2O
show the reaction diagram
-
membrane-bound enzyme form Mem-R,S-Msr
-
-
?
sulindac + NADPH
sulindac sulfide + NADP+ + H2O
show the reaction diagram
-
activation of a methionine sulfoxide-containing prodrug, activity with membrane-bound enzyme form Mem-R,S-Msr
activated drug which inhibits cyclooxygenase 1 and 2 and exhibits anti-inflammatory activity
-
?
additional information
?
-